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solute carrier family 27 member 5

Summary

Gene Symbol

SLC27A5

Aliases

ACSB
ACSVL6
FACVL3
FATP5
FLJ22987
VLACSR
VLCS-H2
VLCSH2
fatty-acid-Coenzyme A ligase, very long-chain 3

Organism

Homo sapiens (human)

External Links

NCBI Gene

10998

HGNC

10999

KEGG Gene ID

hsa:10998

PubChem

10998

Alliance of Genome Resources

HGNC:10999

Annotation

Keyword

ATP-binding
Alternative splicing
Cell membrane
Fatty acid metabolism
Ligase
Lipid transport
Microsome
Oxidoreductase
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y2P5	Bile acid-CoA ligase Bile acyl-CoA synthetase Cholate--CoA ligase Fatty-acid-coenzyme A ligase, very long-chain 3 Long-chain-fatty-acid--CoA ligase Solute carrier family 27 member 5 Very long-chain acyl-CoA synthetase homolog 2 Very long-chain acyl-CoA synthetase-related protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 10 in total

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GO Term	Evidence Code	PMID
long-chain fatty acid import across plasma membrane	IEA
bile acid metabolic process	IBA
triglyceride mobilization	IEA
long-chain fatty acid metabolic process	IBA
bile acid and bile salt transport

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

ketone body biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

ketone body biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

organic hydroxy compound biosynthetic process [inference]

bile acid biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

bile acid metabolic process

bile acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

generation of precursor metabolites and energy [inference]

ketone body metabolic process [inference]

ketone body biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

ketone body biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride mobilization

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride mobilization

cellular ketone body metabolic process [inference]

ketone body biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

bile acid metabolic process

bile acid biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride mobilization

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride mobilization

fatty acid derivative metabolic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

ketone body metabolic process [inference]

ketone body biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

bile acid metabolic process

bile acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

ketone body biosynthetic process

cellular ketone body metabolic process [inference]

ketone body biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

bile acid metabolic process

bile acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

bile acid metabolic process

bile acid biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride mobilization

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride mobilization

fatty acid derivative metabolic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

ketone body metabolic process [inference]

ketone body biosynthetic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

bile acid metabolic process

bile acid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

bile acid biosynthetic process

organic hydroxy compound biosynthetic process [inference]

bile acid biosynthetic process

organic hydroxy compound metabolic process [inference]

bile acid metabolic process

bile acid biosynthetic process

organic hydroxy compound biosynthetic process [inference]

bile acid biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

bile acid metabolic process

bile acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

generation of precursor metabolites and energy [inference]

ketone body metabolic process [inference]

ketone body biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

bile acid biosynthetic process

ketone body biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride mobilization

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride mobilization

cellular ketone body metabolic process [inference]

ketone body biosynthetic process

transmembrane transport [inference]

import across plasma membrane [inference]

long-chain fatty acid import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

localization [inference]

establishment of localization [inference]

transport [inference]

transmembrane transport [inference]

import across plasma membrane [inference]

long-chain fatty acid import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

organic substance transport [inference]

lipid transport [inference]

bile acid and bile salt transport

fatty acid transport [inference]

long-chain fatty acid transport [inference]

long-chain fatty acid import into cell

long-chain fatty acid import across plasma membrane

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

lipid import into cell [inference]

long-chain fatty acid import into cell

long-chain fatty acid import across plasma membrane

organic anion transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

bile acid and bile salt transport

fatty acid transport [inference]

long-chain fatty acid transport [inference]

long-chain fatty acid import into cell

long-chain fatty acid import across plasma membrane

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

bile acid and bile salt transport

fatty acid transport [inference]

long-chain fatty acid transport [inference]

long-chain fatty acid import into cell

long-chain fatty acid import across plasma membrane

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

organic hydroxy compound transport [inference]

bile acid and bile salt transport

import into cell [inference]

long-chain fatty acid import into cell

long-chain fatty acid import across plasma membrane

establishment of localization in cell

Displaying **all 5** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA	10479480
basal plasma membrane	IEA
endoplasmic reticulum membrane	IBA IDA TAS	11980911
plasma membrane	IBA
protein-containing complex	IEA

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

plasma membrane region [inference]

basal plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **6 - 9** of 9 in total

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GO Term	Evidence Code	PMID
long-chain fatty acid-CoA ligase activity	IBA TAS
ATP binding	IEA
protein binding	IPI	32296183
protein-containing complex binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

ligase activity [inference]

ligase activity, forming carbon-sulfur bonds [inference]

CoA-ligase activity [inference]

acid-thiol ligase activity [inference]

fatty acid ligase activity [inference]

cholate-CoA ligase activity

transporter activity [inference]

lipid transporter activity [inference]

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

monocarboxylic acid transmembrane transporter activity [inference]

fatty acid transmembrane transporter activity

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

monocarboxylic acid transmembrane transporter activity [inference]

fatty acid transmembrane transporter activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

fatty acid ligase activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000083807

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K08748

Name

solute carrier family 27 (fatty acid transporter)

References

Orthology

K08748

Name

member 5 [EC:6.2.1.7]

References

Rhea

RHEA:47128

deoxycholate + ATP + CoA

diphosphate + AMP + deoxycholoyl-CoA

Enzyme

6.2.1.7

PMID

RHEA:43764

ATP + chenodeoxycholate + CoA

diphosphate + AMP + chenodeoxycholoyl-CoA

Enzyme

6.2.1.7

PMID

RHEA:15421

ATP + CoA + a long-chain fatty acid

diphosphate + AMP + a long-chain fatty acyl-CoA

Enzyme

6.2.1.3

PMID

RHEA:22976

ATP + CoA + (25R)-3α,7α,12α-trihydroxy-5β-cholestan-26-oate

diphosphate + AMP + (25R)-3α,7α,12α-trihydroxy-5β-cholestan-26-oyl-CoA

Enzyme

6.2.1.7

PMID

RHEA:47136

lithocholate + ATP + CoA

diphosphate + AMP + lithocholoyl-CoA

Enzyme

6.2.1.7

PMID

11980911

RHEA:23532

cholate + ATP + CoA

diphosphate + AMP + choloyl-CoA

Enzyme

6.2.1.7

PMID

Disease

Disease Ontology

Displaying entries **21 - 30** of 91 in total

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DO ID	Disease Name	Source
DOID:11339	pneumocystosis	DisGeNET
DOID:11394	adult respiratory distress syndrome	DisGeNET
DOID:12120	pulmonary alveolar proteinosis	DisGeNET
DOID:12123	postinflammatory pulmonary fibrosis	DisGeNET
DOID:12132	granulomatosis with polyangiitis	DisGeNET
DOID:1227	neutropenia	DisGeNET
DOID:12305	Bloch-Sulzberger syndrome	DisGeNET
DOID:12716	newborn respiratory distress syndrome	DisGeNET
DOID:12987	agranulocytosis	DisGeNET
DOID:13270	erythropoietic protoporphyria	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002315
Gene Name: solute carrier family 27 (fatty acid transporter), member 5

Ortholog

Displaying entries **1 - 10** of 54 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	494096	ZFIN:ZDB-GENE-041212-67
Danio rerio	100004228	ZFIN:ZDB-GENE-081104-49
Danio rerio	100009650	ZFIN:ZDB-GENE-070209-32
Xenopus tropicalis	613067	Xenbase:XB-GENE-1007665
Ornithorhynchus anatinus	100090562		ORNAN00882
Callithrix jacchus	100394591		CALJA23441
Cercocebus atys	105593284		CERAT43157
Macaca fascicularis	102139611		MACFA19345
Macaca mulatta	713713		MACMU17971
Macaca nemestrina	105488041		MACNE42007

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements