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alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A

Summary

Gene Symbol

MGAT4A

Aliases

GnT-4a
GnT-Iva

Organism

Homo sapiens (human)

External Links

NCBI Gene

11320

GGDB ID

gg128

HGNC

7047

mRNA

NM_012214

map

2q12

Protein

NP_036346

OMIM

604623

KEGG Gene ID

hsa:11320

PubChem

11320

Alliance of Genome Resources

HGNC:7047

Annotation

Keyword

3D-structure
Alternative splicing
Coiled coil
Glycoprotein
Glycosyltransferase
Golgi apparatus
Metal-binding
Phosphoprotein
Reference proteome
Secreted
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UM21	N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein glycosylation	IDA	17006639
protein N-linked glycosylation	IBA
N-glycan processing	ISS
viral protein processing	TAS
glyoxylate metabolic process	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

glyoxylate metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

glyoxylate metabolic process

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

glyoxylate metabolic process

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation

organic substance metabolic process [inference]

cellular aldehyde metabolic process [inference]

glyoxylate metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

glyoxylate metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

cellular process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

glyoxylate metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

glyoxylate metabolic process

viral process [inference]

viral protein processing

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GO Term	Evidence Code	PMID
Golgi membrane	TAS
peroxisome	ISS
endoplasmic reticulum	IBA
endoplasmic reticulum lumen	TAS
endoplasmic reticulum-Golgi intermediate compartment	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

Golgi stack

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
acetylglucosaminyltransferase activity	IBA
alanine-glyoxylate transaminase activity	ISS
alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	TAS
alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	IDA	17006639
protein homodimerization activity	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity

alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity

alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity

transferase activity, transferring nitrogenous groups [inference]

transaminase activity [inference]

alanine-glyoxylate transaminase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

alpha-1 3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
acetylglucosaminyltransferase activity
protein N-linked glycosylation

Displaying 1 entry
InterPro
Glycosyl transferase family 54

Human Protein Atlas

ENSG00000071073

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg128

Gene Symbol

MGAT4A

Reactions

Displaying **all 2** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-GlcNAc	G39213VZ	PA	G29011JC	PA	17006639
UDP-GlcNAc	G10219AA	PA	G20030CU	PA	17006639

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Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-GlcNAc	G80858MF	Asn-X	G61207RZ	Asn-X	6222042
UDP-GlcNAc	G39213VZ	Asn-X	G29011JC	Asn-X	6222042
UDP-GlcNAc	G89993FE	PA	G43299SD	PA	17006639
UDP-GlcNAc	G39213VZ	PA	G29011JC	PA	17006639
UDP-GlcNAc	G27919IH	Asn-X	G03445UI	Asn-X	6222042

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Donor	Acceptor	Reducing terminal(Acceptor)	Reference
UDP-GlcNAc	G12045WP	PA	17006639
UDP-GlcNAc	G59471TH	Asn-X	6222042
UDP-GlcNAc	G99858XP	Asn-X	6222042
UDP-GlcNAc	G77252PU	Asn-X	6222042
UDP-GlcNAc	G07483YN	Asn-X	6222042

Orthologous Gene

Displaying **all 3** entries
Species	Protein	mRNA
Drosophila melanogaster	NP_648720	NM_140463
Mus musculus	NP_776295	NM_173870
Rattus norvegicus	XP_218731	XM_218731

KEGG BRITE Database

Orthology

K00738

Name

alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase A/B [EC:2.4.1.145]

References

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05987	2.4.1.145	G39213VZ	G29011JC

Rhea

RHEA:16057

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.145

PMID

Ortholog

Displaying entries **21 - 30** of **103** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	100124983	Xenbase:XB-GENE-968212
Drosophila melanogaster	100145594	FB:FBgn0036446
Pongo abelii	100190826		PONAB22848
Taeniopygia guttata	100218916		TAEGU11504
Oryctolagus cuniculus	100338722		RABIT08318
Callithrix jacchus	100398052		CALJA10631
Ailuropoda melanoleuca	100481251		AILME12047
Sus scrofa	100524079		PIGXX21562
Sus scrofa	100524554		PIGXX21562
Meleagris gallopavo	100538511		MELGA01508

GlyTouCan

GlyComb

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UniCarb-DR

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Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

International Collaboration

Acknowledgements