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Guidelines

MIRAGE

transient receptor potential cation channel, subfamily V, member 6

Summary

Gene Symbol

Trpv6

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

114246

PubChem

114246

Alliance of Genome Resources

RGD:69335

Annotation

Keyword

3D-structure
ANK repeat
Calcium channel
Calmodulin-binding
Cell membrane
Glycoprotein
Ion channel
Metal-binding
Phosphoprotein
Receptor
Reference proteome
Repeat
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B6ZDS2
Q9R186	Calcium transport protein 1 Epithelial calcium channel 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 18 in total

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GO Term	Evidence Code	PMID
response to calcium ion	ISO
response to calcium ion	IEA
calcium ion homeostasis	ISS
calcium ion homeostasis	ISO
calcium ion homeostasis	IEA

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

export from cell [inference]

secretion by cell [inference]

signal release [inference]

hormone secretion [inference]

endocrine hormone secretion [inference]

parathyroid hormone secretion

homeostatic process [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to calcium ion

response to inorganic substance [inference]

response to metal ion [inference]

response to calcium ion

response to oxygen-containing compound [inference]

response to calcium ion

response to salt [inference]

response to calcium ion

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport

calcium ion import

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

hormone transport [inference]

hormone secretion [inference]

endocrine hormone secretion [inference]

parathyroid hormone secretion

secretion [inference]

secretion by cell [inference]

signal release [inference]

hormone secretion [inference]

endocrine hormone secretion [inference]

parathyroid hormone secretion

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

organic substance transport [inference]

calcium ion transport

calcium ion import

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

export from cell [inference]

secretion by cell [inference]

signal release [inference]

hormone secretion [inference]

endocrine hormone secretion [inference]

parathyroid hormone secretion

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

hormone secretion [inference]

endocrine hormone secretion [inference]

parathyroid hormone secretion

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
plasma membrane	ISS
plasma membrane	ISO
plasma membrane	IBA
plasma membrane	IEA
apical plasma membrane	IC	10875938

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

calcium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

calcium channel complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

Displaying entries **11 - 12** of 12 in total

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GO Term	Evidence Code	PMID
identical protein binding	IEA
metal ion binding	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

ligand-gated monoatomic cation channel activity [inference]

calcium-activated cation channel activity

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

calcium-activated cation channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

ligand-gated monoatomic cation channel activity [inference]

calcium-activated cation channel activity

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

ligand-gated monoatomic cation channel activity [inference]

calcium-activated cation channel activity

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

calcium-activated cation channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

calcium-activated cation channel activity

monoatomic ion-gated channel activity [inference]

calcium-activated cation channel activity

salt transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity

binding [inference]

protein binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

transient receptor potential cation channel subfamily V member 6

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
calcium channel activity
calcium ion transmembrane transport
calcium ion transport
monoatomic ion channel activity
monoatomic ion transport

Displaying **all 6** entries
InterPro
Ankyrin repeat-containing domain superfamily
Ankyrin repeat
Ion transport domain
Transient receptor potential cation channel subfamily V member 5/6
Transient receptor potential cation channel subfamily V member 6
Transient receptor potential cation channel subfamily V

Ortholog

Displaying entries **1 - 10** of 77 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	7442	SGD:S000005613
Saccharomyces cerevisiae S288C	22368	SGD:S000005613
Saccharomyces cerevisiae S288C	29465	SGD:S000005613
Saccharomyces cerevisiae S288C	51393	SGD:S000005613
Homo sapiens	55503	Xenbase:XB-GENE-6453137	HUMAN91783
Xenopus tropicalis	56302	Xenbase:XB-GENE-6453137
Saccharomyces cerevisiae S288C	63873	SGD:S000005613
Mus musculus	64177	Xenbase:XB-GENE-6453137	MOUSE47490
Saccharomyces cerevisiae S288C	83810	SGD:S000005613
Xenopus tropicalis	114246	Xenbase:XB-GENE-6453137

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: March 31, 2025