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serine (or cysteine) peptidase inhibitor, clade G, member 1

Summary

Gene Symbol

Serping1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12258

PubChem

12258

Alliance of Genome Resources

MGI:894696

Annotation

Keyword

Complement pathway
Disulfide bond
Fibrinolysis
Glycoprotein
Reference proteome
Secreted
Serine protease inhibitor
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P97290	C1 esterase inhibitor C1-inhibiting factor Serpin G1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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2

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GO Term	Evidence Code	PMID
negative regulation of endopeptidase activity	IBA
negative regulation of peptidase activity	IEA
innate immune response	IEA
complement activation, classical pathway	IEA
negative regulation of complement activation, lectin pathway	ISO ISS

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation [inference]

complement activation, classical pathway

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

immune response [inference]

humoral immune response [inference]

complement activation [inference]

complement activation, classical pathway

innate immune response

multicellular organismal process [inference]

coagulation [inference]

blood coagulation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response

immune response [inference]

humoral immune response [inference]

complement activation [inference]

complement activation, classical pathway

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

regulation of complement activation [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

regulation of immune response [inference]

regulation of humoral immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

regulation of complement activation [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

regulation of innate immune response [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of innate immune response [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of response to external stimulus [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of innate immune response [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of immune response [inference]

regulation of humoral immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

regulation of complement activation [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

regulation of innate immune response [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, classical pathway

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of innate immune response [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of biological quality [inference]

regulation of body fluid levels [inference]

hemostasis [inference]

blood coagulation

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

fibrinolysis

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

Displaying **all 2** entries
GO Term	Evidence Code	PMID
collagen-containing extracellular matrix	HDA	22159717
extracellular space	HDA IBA IDA ISO	24006456 9652403

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

Displaying **all 2** entries
GO Term	Evidence Code	PMID
serine-type endopeptidase inhibitor activity	IBA IDA ISO ISS	9199246
complement binding	IPI	9652403

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

complement binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

plasma protease C1 inhibitor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
serine-type endopeptidase inhibitor activity

Displaying **all 6** entries
InterPro
Serpin domain
Serpin family
Serpin superfamily, domain 1
Serpin superfamily, domain 2
Serpin superfamily
Serpin, conserved site

Disease

Disease Ontology

Displaying entries **1 - 10** of 12 in total

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2

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DO ID	Disease Name	Source
DOID:0080600	COVID-19	Alliance of Genome Resources
DOID:0080939	hereditary angioedema type I	Alliance of Genome Resources
DOID:0080998	acute necrotizing pancreatitis	Alliance of Genome Resources
DOID:14115	toxic shock syndrome	Alliance of Genome Resources
DOID:14735	hereditary angioedema	Alliance of Genome Resources
DOID:1558	angioedema	Alliance of Genome Resources
DOID:3068	glioblastoma	Alliance of Genome Resources
DOID:3526	cerebral infarction	Alliance of Genome Resources
DOID:4448	macular degeneration	Alliance of Genome Resources
DOID:4989	pancreatitis	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 90 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Callithrix jacchus	100386447		CALJA02969
Nomascus leucogenys	100583544		NOMLE28846
Cavia porcellus	100735994	10141_0:000f9a	CAVPO20847
Cricetulus griseus	100756452	10029_0:003f97
Otolemur garnettii	100951100		OTOGA02226
Pan paniscus	100983502		PANPA06692
Pan paniscus	100994793		PANPA06692
Papio anubis	101018398		PAPAN05135
Saimiri boliviensis boliviensis	101047725		SAIBB00777
Felis catus	101087683		FELCA24610

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements