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protein disulfide isomerase associated 4

Summary

Gene Symbol

Pdia4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12304

PubChem

12304

Alliance of Genome Resources

MGI:104864

Annotation

Keyword

3D-structure
Acetylation
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Isomerase
Proteomics identification
Redox-active center
Reference proteome
Repeat
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0R4J0Z1	Endoplasmic reticulum resident protein 72
P08003	Endoplasmic reticulum resident protein 72

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
protein folding	IBA
response to endoplasmic reticulum stress	IBA
chaperone-mediated protein folding	ISS
chaperone-mediated protein folding	ISO
platelet aggregation	IMP	28576878

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

protein activation cascade [inference]

blood coagulation, fibrin clot formation

primary metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

protein activation cascade [inference]

blood coagulation, fibrin clot formation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

protein activation cascade [inference]

blood coagulation, fibrin clot formation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

protein activation cascade [inference]

blood coagulation, fibrin clot formation

cellular process [inference]

protein folding

chaperone-mediated protein folding

cell adhesion [inference]

cell-cell adhesion [inference]

homotypic cell-cell adhesion [inference]

platelet aggregation

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of protein folding

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of protein folding

regulation of protein folding [inference]

positive regulation of protein folding

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GO Term	Evidence Code	PMID
extracellular space	ISO
endoplasmic reticulum	IDA	24239381 35353806 9493907
endoplasmic reticulum	IBA
endoplasmic reticulum lumen	IEA
smooth endoplasmic reticulum	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

endoplasmic reticulum protein-containing complex [inference]

endoplasmic reticulum chaperone complex

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

smooth endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

smooth endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

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GO Term	Evidence Code	PMID
protein disulfide isomerase activity	ISS
protein disulfide isomerase activity	ISO
protein disulfide isomerase activity	IDA	28576878
protein disulfide isomerase activity	IBA
integrin binding	IPI	28576878

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on a sulfur group of donors [inference]

disulfide oxidoreductase activity [inference]

protein-disulfide reductase activity

isomerase activity [inference]

intramolecular oxidoreductase activity [inference]

intramolecular oxidoreductase activity, transposing S-S bonds [inference]

protein disulfide isomerase activity

catalytic activity, acting on a protein [inference]

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

integrin binding

cell adhesion molecule binding [inference]

integrin binding

protein-containing complex binding [inference]

integrin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Disulfide isomerase

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 2** entries
Gene Ontology
isomerase activity
response to endoplasmic reticulum stress

Displaying **all 5** entries
InterPro
Protein disulfide-isomerase, thioredoxin-like domain
Protein disulphide isomerase
Thioredoxin domain
Thioredoxin, conserved site
Thioredoxin-like superfamily

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	2923	SGD:S000000548
Saccharomyces cerevisiae S288C	5034	SGD:S000000548
Homo sapiens	9601	Xenbase:XB-GENE-5892157	HUMAN91924
Xenopus tropicalis	12304	Xenbase:XB-GENE-5892157
Saccharomyces cerevisiae S288C	14827	SGD:S000000548
Saccharomyces cerevisiae S288C	64714	SGD:S000000548
Saccharomyces cerevisiae S288C	69191	SGD:S000000548
Rattus norvegicus	116598		RATNO31242
Saccharomyces cerevisiae S288C	180724	SGD:S000000548
Bos taurus	415110		BOVIN28691