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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
catechol-O-methyltransferase
Summary
- Gene Symbol
-
- COMT
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative initiation
- Catecholamine metabolism
- Cell membrane
- Cytoplasm
- Direct protein sequencing
- Lipid metabolism
- Magnesium
- Metal-binding
- Methyltransferase
- Neurotransmitter degradation
- Phosphoprotein
- Reference proteome
- S-adenosyl-L-methionine
- Schizophrenia
- Signal-anchor
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| P21964 |
|
| A0A140VJG8 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| response to oxidative stress | ||
| cellular response to phosphate starvation | ||
| methylation | ||
| visual learning | ||
| response to wounding |
GO Hierarchy
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
localization [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| plasma membrane | ||
| membrane | ||
| extracellular exosome |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| magnesium ion binding | ||
| L-dopa O-methyltransferase activity |
|
|
| orcinol O-methyltransferase activity |
|
|
| protein binding | ||
| catechol O-methyltransferase activity |
GO Hierarchy
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050158 | desquamative interstitial pneumonia | |
| DOID:0050328 | congenital hypothyroidism | |
| DOID:0050427 | xeroderma pigmentosum | |
| DOID:0050453 | lissencephaly | |
| DOID:0050635 | alternating hemiplegia of childhood | |
| DOID:0050741 | alcohol dependence | |
| DOID:0050742 | nicotine dependence | |
| DOID:0050771 | pheochromocytoma | |
| DOID:0050778 | Meckel syndrome | |
| DOID:0050848 | obstructive sleep apnea |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0001561 | Polyhydramnios |
| HP:0001601 | Laryngomalacia |
| HP:0001611 | Hypernasal speech |
| HP:0001629 | Ventricular septal defect |
| HP:0001631 | Atrial septal defect |
| HP:0001636 | Tetralogy of Fallot |
| HP:0001641 | Abnormal pulmonary valve morphology |
| HP:0001643 | Patent ductus arteriosus |
| HP:0001646 | Abnormal aortic valve morphology |
| HP:0001660 | Truncus arteriosus |
| Disease ID | Disease Name |
|---|---|
| OMIM:181500 |
|
| ORPHA:567 |
|
| OMIM:167870 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 103183994 | CALMI28692 | ||
| 102363275 | LATCH17564 | ||
| 561372 | ZFIN:ZDB-GENE-050913-117 | DANRE42593 | |
| 565370 | ZFIN:ZDB-GENE-040724-164 | DANRE01869 | |
| 103025058 | ASTMX04013 | ||
| 108265311 | ICTPU30273 | ||
| 124625982 | ICTPU30274 | ||
| 113573090 | ELEEL08877 | ||
| 115150851 | SALTR33931 | ||
| 115168561 | SALTR76287 |
