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UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1

Summary

Gene Symbol

B4galt1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14595

KEGG Gene ID

mmu:14595

PubChem

14595

Alliance of Genome Resources

MGI:95705

Annotation

Keyword

Alternative initiation
Cell membrane
Cell projection
Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Lipid metabolism
Manganese
Metal-binding
Reference proteome
Secreted
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P15535	Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase Lactose synthase A protein N-acetyllactosamine synthase Nal synthase Neolactotriaosylceramide beta-1,4-galactosyltransferase UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1 UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1
Q3U478

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
oligosaccharide biosynthetic process	IDA ISO	9813328
protein N-linked glycosylation	IBA ISO
acute inflammatory response	IMP	12714507
carbohydrate metabolic process	IEA
wound healing	IMP	15039218

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration [inference]

myeloid leukocyte migration [inference]

macrophage migration

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

galactose metabolic process

oligosaccharide metabolic process [inference]

disaccharide metabolic process [inference]

lactose metabolic process [inference]

lactose biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

oligosaccharide biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

lipid metabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

galactose metabolic process

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

galactose metabolic process

oligosaccharide metabolic process [inference]

disaccharide metabolic process [inference]

lactose metabolic process [inference]

lactose biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

oligosaccharide biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

lipid metabolic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process

cellular process [inference]

cell adhesion

cell recognition [inference]

cell-cell recognition [inference]

sperm-egg recognition [inference]

binding of sperm to zona pellucida

cell population proliferation

epithelial cell proliferation

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

cellular developmental process [inference]

cell development [inference]

epithelial cell development

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

myeloid leukocyte migration [inference]

macrophage migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

reproductive process [inference]

developmental process involved in reproduction [inference]

development of secondary sexual characteristics

sperm-egg recognition [inference]

binding of sperm to zona pellucida

multicellular organismal reproductive process [inference]

penetration of zona pellucida

multicellular organismal process [inference]

multi-multicellular organism process [inference]

penetration of zona pellucida

developmental process [inference]

developmental process involved in reproduction [inference]

development of secondary sexual characteristics

anatomical structure formation involved in morphogenesis [inference]

angiogenesis [inference]

angiogenesis involved in wound healing

anatomical structure development [inference]

cell development [inference]

epithelial cell development

cellular developmental process [inference]

cell development [inference]

epithelial cell development

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response [inference]

acute inflammatory response

response to wounding [inference]

wound healing

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation involved in wound healing

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation involved in wound healing

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation

regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation involved in wound healing

negative regulation of epithelial cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation involved in wound healing

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation

regulation of reproductive process [inference]

regulation of acrosome reaction

regulation of biological quality [inference]

regulation of circulating fibrinogen levels [inference]

positive regulation of circulating fibrinogen levels

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GO Term	Evidence Code	PMID
filopodium
extracellular region	IEA
external side of plasma membrane	ISO
cell surface	IDA	9374408
plasma membrane	IDA	11375348 2503706

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

Golgi cisterna membrane

plasma membrane region [inference]

basolateral plasma membrane

cell projection membrane [inference]

brush border membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

desmosome

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

Golgi cisterna [inference]

Golgi trans cisterna

cell projection

plasma membrane bounded cell projection [inference]

actin-based cell projection [inference]

filopodium

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	IBA IDA IMP ISO	10381349 11900463 9013935 9155011 9588205 9813328
cytoskeletal protein binding	IBA
glycosyltransferase activity	IEA
beta-tubulin binding	ISO
transferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity

glycosyltransferase activity

UDP-glycosyltransferase activity [inference]

UDP-galactosyltransferase activity

hexosyltransferase activity [inference]

galactosyltransferase activity

UDP-galactosyltransferase activity

binding [inference]

protein binding

cytoskeletal protein binding

tubulin binding [inference]

identical protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

manganese ion binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K07966

Name

beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-]

References

Reactions

Displaying **all 4** entries
KEGG Reaction	Enzyme	Acceptor	Product
R05989	2.4.1.38	G80858MF	G78059CC
R05977	2.4.1.- 2.4.1.275	G06239NA	G58896AZ
R06033	2.4.1.-	G70874WW	G84034JH
R07617	2.4.1.-	G00033MO	G64973KT

Rhea

RHEA:17745

N-acetyl-D-glucosamine + UDP-α-D-galactose

H⁺ + UDP + β-D-galactosyl-(1→4)-N-acetyl-D-glucosamine

Enzyme

2.4.1.90

PMID

RHEA:22932

an N-acetyl-β-D-glucosaminyl derivative + UDP-α-D-galactose

a β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl derivative + H⁺ + UDP

Enzyme

2.4.1.38

PMID

RHEA:12404

D-glucose + UDP-α-D-galactose

H⁺ + lactose + UDP

Enzyme

2.4.1.22

PMID

RHEA:31499

a β-D-GlcNAc-(1→3)-β-D-Gal-(1→4)-β-D-Glc-(1↔1)-Cer(d18:1(4E)) + UDP-α-D-galactose

H⁺ + a neolactoside nLc4Cer(d18:1(4E)) + UDP

Enzyme

2.4.1.275

PMID

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0070256	congenital disorder of glycosylation type IId	Alliance of Genome Resources
DOID:28	endocrine system disease	Alliance of Genome Resources
DOID:2986	IgA glomerulonephritis	Alliance of Genome Resources
DOID:5212	congenital disorder of glycosylation	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002081
Gene Name: UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1

Ortholog

Displaying entries **1 - 10** of 80 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	190668	WB:WBGene00000269
Drosophila melanogaster	36585	FB:FBgn0027538
Danio rerio	768123	ZFIN:ZDB-GENE-061013-84	DANRE06581
Danio rerio	550425	ZFIN:ZDB-GENE-050417-236
Ictalurus punctatus	108260689		ICTPU23585
Ictalurus punctatus	108277608		ICTPU25345
Electrophorus electricus	113583532		ELEEL32109
Electrophorus electricus	113583542		ELEEL32107
Electrophorus electricus	113587936		ELEEL40055
Electrophorus electricus	118241983		ELEEL32109

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements