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UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1

Summary

Gene Symbol

B4galt1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14595

KEGG Gene ID

mmu:14595

PubChem

14595

Alliance of Genome Resources

MGI:95705

Annotation

Keyword

Alternative initiation
Cell membrane
Cell projection
Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Lipid metabolism
Manganese
Metal-binding
Reference proteome
Secreted
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P15535	Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase Lactose synthase A protein N-acetyllactosamine synthase Nal synthase Neolactotriaosylceramide beta-1,4-galactosyltransferase UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1 UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1
Q3U478

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 38 in total

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GO Term	Evidence Code	PMID
epithelial cell development	IMP	9155011
acute inflammatory response	IMP	12714507
lactose biosynthetic process	IMP	9155011
galactose metabolic process	IDA	9813328
protein glycosylation	IMP	9155011

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration [inference]

myeloid leukocyte migration [inference]

macrophage migration

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

galactose metabolic process

oligosaccharide metabolic process [inference]

disaccharide metabolic process [inference]

lactose metabolic process [inference]

lactose biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

oligosaccharide biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

lipid metabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

galactose metabolic process

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

galactose metabolic process

oligosaccharide metabolic process [inference]

disaccharide metabolic process [inference]

lactose metabolic process [inference]

lactose biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

oligosaccharide biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

lipid metabolic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

macromolecule glycosylation [inference]

protein glycosylation

protein N-linked glycosylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein modification process [inference]

protein glycosylation

protein N-linked glycosylation

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process

cellular process [inference]

cell adhesion

cell-substrate adhesion [inference]

cell-matrix adhesion

cell recognition [inference]

cell-cell recognition [inference]

sperm-egg recognition [inference]

binding of sperm to zona pellucida

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

apoptotic process involved in development [inference]

apoptotic process involved in morphogenesis [inference]

apoptotic process involved in mammary gland involution

cell population proliferation

epithelial cell proliferation

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

cellular developmental process [inference]

cell development [inference]

epithelial cell development

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

myeloid leukocyte migration [inference]

macrophage migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

reproductive process [inference]

developmental process involved in reproduction [inference]

development of secondary sexual characteristics

sperm-egg recognition [inference]

binding of sperm to zona pellucida

multicellular organismal reproductive process [inference]

penetration of zona pellucida

multicellular organismal process [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube

multi-multicellular organism process [inference]

penetration of zona pellucida

developmental process [inference]

developmental process involved in reproduction [inference]

development of secondary sexual characteristics

anatomical structure morphogenesis [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube

tube morphogenesis [inference]

branching morphogenesis of an epithelial tube

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube

anatomical structure formation involved in morphogenesis [inference]

angiogenesis [inference]

angiogenesis involved in wound healing

anatomical structure development [inference]

cell development [inference]

epithelial cell development

animal organ development [inference]

gland development [inference]

mammary gland development

cellular developmental process [inference]

cell development [inference]

epithelial cell development

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response [inference]

acute inflammatory response

response to wounding [inference]

wound healing

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation involved in wound healing

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of apoptotic process involved in development [inference]

positive regulation of apoptotic process involved in morphogenesis [inference]

positive regulation of apoptotic process involved in mammary gland involution

positive regulation of developmental process [inference]

positive regulation of apoptotic process involved in development [inference]

positive regulation of apoptotic process involved in morphogenesis [inference]

positive regulation of apoptotic process involved in mammary gland involution

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of epithelial cell proliferation

regulation of developmental process [inference]

positive regulation of developmental process [inference]

positive regulation of apoptotic process involved in development [inference]

positive regulation of apoptotic process involved in morphogenesis [inference]

positive regulation of apoptotic process involved in mammary gland involution

regulation of apoptotic process involved in development [inference]

regulation of apoptotic process involved in morphogenesis [inference]

positive regulation of apoptotic process involved in morphogenesis [inference]

positive regulation of apoptotic process involved in mammary gland involution

positive regulation of apoptotic process involved in development [inference]

positive regulation of apoptotic process involved in morphogenesis [inference]

positive regulation of apoptotic process involved in mammary gland involution

regulation of cellular process [inference]

regulation of cell population proliferation

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation involved in wound healing

negative regulation of cell population proliferation

negative regulation of epithelial cell proliferation

regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation involved in wound healing

negative regulation of epithelial cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of apoptotic process involved in development [inference]

positive regulation of apoptotic process involved in morphogenesis [inference]

positive regulation of apoptotic process involved in mammary gland involution

regulation of apoptotic process involved in development [inference]

regulation of apoptotic process involved in morphogenesis [inference]

positive regulation of apoptotic process involved in morphogenesis [inference]

positive regulation of apoptotic process involved in mammary gland involution

positive regulation of apoptotic process involved in development [inference]

positive regulation of apoptotic process involved in morphogenesis [inference]

positive regulation of apoptotic process involved in mammary gland involution

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of apoptotic process involved in development [inference]

positive regulation of apoptotic process involved in morphogenesis [inference]

positive regulation of apoptotic process involved in mammary gland involution

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation involved in wound healing

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of apoptotic process involved in development [inference]

positive regulation of apoptotic process involved in morphogenesis [inference]

positive regulation of apoptotic process involved in mammary gland involution

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of epithelial cell proliferation

regulation of cell motility [inference]

regulation of cell migration

regulation of reproductive process [inference]

regulation of acrosome reaction

regulation of biological quality [inference]

regulation of circulating fibrinogen levels [inference]

positive regulation of circulating fibrinogen levels

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GO Term	Evidence Code	PMID
Golgi trans cisterna	ISO
Golgi trans cisterna	IEA
extracellular region	IEA
Golgi apparatus	ISO
Golgi apparatus	IDA	11375348 2503706

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

Golgi cisterna membrane

plasma membrane region [inference]

basolateral plasma membrane

cell projection membrane [inference]

brush border membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

desmosome

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

Golgi cisterna [inference]

Golgi trans cisterna

cell projection [inference]

plasma membrane bounded cell projection [inference]

actin-based cell projection [inference]

filopodium

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

side of membrane [inference]

external side of plasma membrane

Displaying entries **6 - 10** of 18 in total

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GO Term	Evidence Code	PMID
N-acetyllactosamine synthase activity	IEA
lactose synthase activity	ISO
lactose synthase activity	IMP	9155011
protein binding	IPI	8089187 9374408
cytoskeletal protein binding

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

UDP-galactosyltransferase activity

hexosyltransferase activity [inference]

galactosyltransferase activity

UDP-galactosyltransferase activity

binding [inference]

protein binding

cytoskeletal protein binding

tubulin binding [inference]

identical protein binding

laminin binding [inference]

laminin binding involved in cell-matrix adhesion

cell adhesion molecule binding [inference]

cell adhesion mediator activity [inference]

cell-matrix adhesion mediator activity [inference]

laminin binding involved in cell-matrix adhesion

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

manganese ion binding

extracellular matrix binding [inference]

laminin binding [inference]

laminin binding involved in cell-matrix adhesion

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Beta-1,4-galactosyltransferase

Functional Category

K: Transcription
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
cytoskeletal protein binding
metal ion binding
protein N-linked glycosylation
transferase activity

Displaying **all 4** entries
InterPro
Beta-1,4-galactosyltransferase
Galactosyltransferase, C-terminal
Galactosyltransferase, N-terminal
Nucleotide-diphospho-sugar transferases

KEGG BRITE Database

Orthology

K07966

Name

beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-]

References

Reactions

Displaying **all 4** entries
KEGG Reaction	Enzyme	Acceptor	Product
R05977	2.4.1.- 2.4.1.275	G06239NA	G58896AZ
R05989	2.4.1.38	G80858MF	G78059CC
R07617	2.4.1.-	G00033MO	G64973KT
R06033	2.4.1.-	G70874WW	G84034JH

Rhea

RHEA:17745

N-acetyl-D-glucosamine + UDP-α-D-galactose

H⁺ + UDP + β-D-galactosyl-(1→4)-N-acetyl-D-glucosamine

Enzyme

2.4.1.90

PMID

RHEA:12404

D-glucose + UDP-α-D-galactose

H⁺ + lactose + UDP

Enzyme

2.4.1.22

PMID

RHEA:22932

an N-acetyl-β-D-glucosaminyl derivative + UDP-α-D-galactose

a β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl derivative + H⁺ + UDP

Enzyme

2.4.1.38

PMID

RHEA:31499

a β-D-GlcNAc-(1→3)-β-D-Gal-(1→4)-β-D-Glc-(1↔1)-Cer(d18:1(4E)) + UDP-α-D-galactose

H⁺ + a neolactoside nLc4Cer(d18:1(4E)) + UDP

Enzyme

2.4.1.275

PMID

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:28	endocrine system disease	Alliance of Genome Resources
DOID:2986	IgA glomerulonephritis	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002081
Gene Name: UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	2683	Xenbase:XB-GENE-5871724	HUMAN96719
Drosophila melanogaster	8702	FB:FBgn0027538
Drosophila melanogaster	8703	FB:FBgn0027538
Drosophila melanogaster	8704	FB:FBgn0027538
Drosophila melanogaster	9334	FB:FBgn0027538
Xenopus tropicalis	14595	Xenbase:XB-GENE-5871724
Rattus norvegicus	24390	Xenbase:XB-GENE-1015082	RATNO32617
Xenopus tropicalis	36585	Xenbase:XB-GENE-5871724
Drosophila melanogaster	53418	FB:FBgn0027538
Drosophila melanogaster	56336	FB:FBgn0027538

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements