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Ground-like domain-containing protein

Summary

Gene Symbol

grd-2

Organism

Caenorhabditis elegans

External Links

NCBI Gene

180349

PubChem

180349

Alliance of Genome Resources

WB:WBGene00001691

Annotation

Keyword

Developmental protein
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9XV14

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
system development	IEA
intein-mediated protein splicing
nematode male tail mating organ morphogenesis	IMP	16204193
protein autoprocessing	IEA
multicellular organism development	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

protein autoprocessing

protein splicing [inference]

intein-mediated protein splicing

protein maturation [inference]

protein processing [inference]

protein autoprocessing

protein splicing [inference]

intein-mediated protein splicing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

protein autoprocessing

protein splicing [inference]

intein-mediated protein splicing

protein maturation [inference]

protein processing [inference]

protein autoprocessing

protein splicing [inference]

intein-mediated protein splicing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

protein autoprocessing

protein splicing [inference]

intein-mediated protein splicing

protein maturation [inference]

protein processing [inference]

protein autoprocessing

protein splicing [inference]

intein-mediated protein splicing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

protein autoprocessing

protein splicing [inference]

intein-mediated protein splicing

protein maturation [inference]

protein processing [inference]

protein autoprocessing

protein splicing [inference]

intein-mediated protein splicing

cellular process [inference]

cell communication [inference]

cell-cell signaling

reproductive process [inference]

developmental process involved in reproduction [inference]

genitalia morphogenesis [inference]

male genitalia morphogenesis [inference]

nematode male tail mating organ morphogenesis

male anatomical structure morphogenesis [inference]

male genitalia morphogenesis [inference]

nematode male tail mating organ morphogenesis

multicellular organismal process [inference]

multicellular organism development

developmental process [inference]

developmental process involved in reproduction [inference]

genitalia morphogenesis [inference]

male genitalia morphogenesis [inference]

nematode male tail mating organ morphogenesis

male anatomical structure morphogenesis [inference]

male genitalia morphogenesis [inference]

nematode male tail mating organ morphogenesis

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

genitalia morphogenesis [inference]

male genitalia morphogenesis [inference]

nematode male tail mating organ morphogenesis

sensory organ morphogenesis [inference]

nematode male tail mating organ morphogenesis

male anatomical structure morphogenesis [inference]

male genitalia morphogenesis [inference]

nematode male tail mating organ morphogenesis

anatomical structure development [inference]

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular matrix	IBA
extracellular region	IEA ISS	10523520

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

Displaying **all 3** entries
GO Term	Evidence Code	PMID
signaling receptor binding	ISS	10523520
endopeptidase activity	ISS	10523520
cholesterol binding	ISS	10523520

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

binding [inference]

protein binding [inference]

signaling receptor binding

lipid binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

small molecule binding [inference]

alcohol binding [inference]

cholesterol binding

organic cyclic compound binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

hedgehog

Functional Category

L: Replication, recombination and repair
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying entries **1 - 10** of 11 in total

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Gene Ontology
calcium ion binding
cell fate specification
cell-cell signaling
hydrolase activity
intein-mediated protein splicing
metal ion binding
patched binding
protein autoprocessing
proteolysis
regulation of gene expression

Displaying **all 8** entries
InterPro
Hedgehog protein, Hint domain
Hedgehog protein
Hedgehog signalling/DD-peptidase zinc-binding domain superfamily
Hedgehog, N-terminal signalling domain
Hint domain C-terminal
Hint domain N-terminal
Hint domain superfamily
Intein N-terminal splicing region

Disease

Disease Ontology

Displaying entries **1 - 10** of 39 in total

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DO ID	Disease Name	Source
DOID:0050338	primary bacterial infectious disease	Alliance of Genome Resources
DOID:0050424	familial adenomatous polyposis	Alliance of Genome Resources
DOID:0050604	acrocapitofemoral dysplasia	Alliance of Genome Resources
DOID:0050784	primary progressive multiple sclerosis	Alliance of Genome Resources
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources
DOID:0060071	pre-malignant neoplasm	Alliance of Genome Resources
DOID:0060850	annular pancreas	Alliance of Genome Resources
DOID:0080171	esophageal atresia/tracheoesophageal fistula	Alliance of Genome Resources
DOID:0080855	Parkinsonism	Alliance of Genome Resources
DOID:0110875	holoprosencephaly 3	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 14 in total

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Species	Gene ID	Alliance of Genome Resources
Homo sapiens	3549	HGNC:5956
Homo sapiens	6469	HGNC:10848
Mus musculus	13363	MGI:94891
Mus musculus	16147	MGI:96533
Mus musculus	20423	MGI:98297
Rattus norvegicus	29499	RGD:3673
Danio rerio	30299	ZFIN:ZDB-GENE-980526-135
Drosophila melanogaster	42737	FB:FBgn0004644
Homo sapiens	50846	HGNC:2865
Rattus norvegicus	84380	RGD:620711

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements