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MIRAGE
sonic hedgehog
Summary
- Gene Symbol
-
- Shh
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- 3D-structure
- Autocatalytic cleavage
- Calcium
- Cell membrane
- Developmental protein
- Endoplasmic reticulum
- Glycoprotein
- Golgi apparatus
- Metal-binding
- Palmitate
- Protease
- Reference proteome
- Signal
- Transferase
- Zinc
- Proteins
| UniProt | Protein Name |
|---|---|
| Q62226 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| branching involved in blood vessel morphogenesis | ||
| vasculogenesis | ||
| metanephros development | ||
| branching involved in ureteric bud morphogenesis | ||
| cell fate specification |
GO Hierarchy
- epithelial-mesenchymal signaling involved in prostate gland development
- mesenchymal-epithelial cell signaling involved in prostate gland development
- epithelial cell proliferation involved in prostate gland development
- mesenchymal smoothened signaling pathway involved in prostate gland development
- positive regulation of cell division
- positive regulation of cell division
biological process
metabolic process [inference]
cellular process [inference]
reproductive process [inference]
developmental process involved in reproduction [inference]
multicellular organismal process [inference]
developmental process [inference]
developmental process involved in reproduction [inference]
anatomical structure morphogenesis [inference]
anatomical structure development
response to stimulus [inference]
localization [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
negative regulation of immune system process [inference]
positive regulation of immune system process [inference]
regulation of leukocyte activation [inference]
negative regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of lymphocyte proliferation [inference]
regulation of T cell activation [inference]
negative regulation of lymphocyte activation [inference]
regulation of hemopoiesis [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of catabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of nitrogen compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
negative regulation of macromolecule metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of RNA metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
regulation of localization [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of metabolic process [inference]
positive regulation of cellular process [inference]
positive regulation of cell population proliferation
positive regulation of cell differentiation [inference]
positive regulation of cell adhesion [inference]
positive regulation of cell activation [inference]
positive regulation of developmental process [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of biological process [inference]
negative regulation of immune system process [inference]
negative regulation of metabolic process [inference]
negative regulation of cellular process [inference]
negative regulation of multicellular organismal process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cell differentiation [inference]
positive regulation of cell differentiation [inference]
regulation of neuron differentiation [inference]
regulation of muscle cell differentiation [inference]
regulation of cell development [inference]
positive regulation of developmental process [inference]
regulation of multicellular organismal development [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cell adhesion [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of cell population proliferation
regulation of cell differentiation [inference]
positive regulation of cell differentiation [inference]
regulation of neuron differentiation [inference]
regulation of muscle cell differentiation [inference]
regulation of cell development [inference]
positive regulation of cellular process [inference]
positive regulation of cell population proliferation
positive regulation of cell differentiation [inference]
positive regulation of cell adhesion [inference]
positive regulation of cell activation [inference]
negative regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
negative regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of lymphocyte proliferation [inference]
regulation of T cell activation [inference]
negative regulation of lymphocyte activation [inference]
negative regulation of cell activation [inference]
positive regulation of cell activation [inference]
regulation of cellular localization [inference]
regulation of multicellular organismal process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
negative regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of lymphocyte proliferation [inference]
regulation of T cell activation [inference]
negative regulation of lymphocyte activation [inference]
negative regulation of cell activation [inference]
positive regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of multicellular organismal process [inference]
regulation of multicellular organismal development [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| Golgi membrane | ||
| extracellular region | ||
| extracellular region | ||
| extracellular space | ||
| extracellular space |
| GO Term | Evidence Code | PMID |
|---|---|---|
| patched binding | ||
| patched binding | ||
| patched binding | ||
| calcium ion binding | ||
| calcium ion binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- hedgehog
- Functional Category
-
- L: Replication, recombination and repair
- T: Signal transduction mechanisms
- X: Mobilome: prophages, transposons
| Gene Ontology |
|---|
| calcium ion binding |
| cell fate specification |
| cell-cell signaling |
| hydrolase activity |
| intein-mediated protein splicing |
| metal ion binding |
| patched binding |
| protein autoprocessing |
| proteolysis |
| regulation of gene expression |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110875 | holoprosencephaly 3 | |
| DOID:2512 | nevoid basal cell carcinoma syndrome |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 3549 | FB:FBgn0004644 | ||
| 6469 | Xenbase:XB-GENE-488039 | HUMAN92227 | |
| 16147 | FB:FBgn0004644 | ||
| 20423 | Xenbase:XB-GENE-488039 | ||
| 29499 | Xenbase:XB-GENE-488039 | RATNO30914 | |
| 30269 | DANRE40080 | ||
| 180349 | HGNC:10848 | ||
| 180638 | HGNC:10848 | ||
| 181300 | FB:FBgn0004644 | ||
| 445636 | CIOIN09955 |
