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complement factor H-related 4

Summary

Gene Symbol

Cfhr4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

214403

PubChem

214403

Alliance of Genome Resources

MGI:3646434

Annotation

Keyword

Disulfide bond
Proteomics identification
Reference proteome
Signal
Sushi

Proteins

Displaying **all 5** entries
UniProt	Protein Name
E9Q8B6
Q0KHD2
E9Q8B5
Q0KHD3
B2RUG5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
proteolysis	ISO
regulation of complement activation	ISO
regulation of complement activation, alternative pathway	ISO
complement activation	IBA ISO

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

activation of immune response [inference]

complement activation

immune response [inference]

humoral immune response [inference]

complement activation

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

response to stimulus [inference]

immune response [inference]

humoral immune response [inference]

complement activation

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of immune effector process [inference]

regulation of complement activation

regulation of complement activation, alternative pathway

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of complement activation

regulation of complement activation, alternative pathway

regulation of innate immune response [inference]

regulation of complement activation, alternative pathway

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of innate immune response [inference]

regulation of complement activation, alternative pathway

regulation of response to external stimulus [inference]

regulation of innate immune response [inference]

regulation of complement activation, alternative pathway

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of complement activation

regulation of complement activation, alternative pathway

regulation of innate immune response [inference]

regulation of complement activation, alternative pathway

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of innate immune response [inference]

regulation of complement activation, alternative pathway

Displaying **all 3** entries
GO Term	Evidence Code	PMID
serine-type endopeptidase complex	ISO
symbiont cell surface	ISO
extracellular space	IBA IDA ISO	17028856

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

peptidase complex [inference]

serine-type peptidase complex [inference]

serine-type endopeptidase complex

endopeptidase complex [inference]

serine-type endopeptidase complex

cellular anatomical entity [inference]

extracellular space

other organism part [inference]

symbiont cell surface

Displaying **all 4** entries
GO Term	Evidence Code	PMID
heparin binding	IDA ISO	17028856
heparan sulfate proteoglycan binding	ISO
complement component C3b binding	IBA IPI	17028856
identical protein binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

opsonin binding [inference]

complement component C3b binding

complement binding [inference]

complement component C3b binding

identical protein binding

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

sulfur compound binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

complement factor H

Functional Category

M: Cell wall/membrane/envelope biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 2** entries
Gene Ontology
complement activation
complement component C3b binding

Displaying **all 2** entries
InterPro
Sushi/SCR/CCP domain
Sushi/SCR/CCP superfamily

Disease

Disease Ontology

Displaying entries **1 - 10** of 26 in total

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DO ID	Disease Name	Source
DOID:0060746	basal laminar drusen	Alliance of Genome Resources
DOID:0080162	lupus nephritis	Alliance of Genome Resources
DOID:0080301	atypical hemolytic-uremic syndrome	Alliance of Genome Resources
DOID:0080600	COVID-19	Alliance of Genome Resources
DOID:0110017	age related macular degeneration 4	Alliance of Genome Resources
DOID:10976	membranous glomerulonephritis	Alliance of Genome Resources
DOID:11335	sarcoidosis	Alliance of Genome Resources
DOID:12030	panuveitis	Alliance of Genome Resources
DOID:12554	hemolytic-uremic syndrome	Alliance of Genome Resources
DOID:12574	posterior uveitis	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 69 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Jaculus jaculus	101597401			JACJA10673
Mustela putorius furo	101691226			MUSPF11928
Heterocephalus glaber	101715308			HETGA14995
Ficedula albicollis	101818719			FICAL04203
Melopsittacus undulatus	101870692			MELUD16224
Ictidomys tridecemlineatus	101961962	43179_0:004d30
Ictidomys tridecemlineatus	101973713	43179_0:004cda
Microtus ochrogaster	101991336	79684_0:000f4a
Chinchilla lanigera	102022667			CHILA01582
Capra hircus	102188881			CAPHI06507

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Last updated: December 9, 2024