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complement factor H-related 4

Summary

Gene Symbol

Cfhr4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

214403

PubChem

214403

Alliance of Genome Resources

MGI:3646434

Annotation

Keyword

Disulfide bond
Proteomics identification
Reference proteome
Signal
Sushi

Proteins

Displaying **all 5** entries
UniProt	Protein Name
E9Q8B6
Q0KHD2
E9Q8B5
Q0KHD3
B2RUG5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
proteolysis	ISO
regulation of complement activation	ISO
regulation of complement activation, alternative pathway	ISO
complement activation	IBA ISO

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

activation of immune response [inference]

complement activation

immune response [inference]

humoral immune response [inference]

complement activation

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

response to stimulus [inference]

immune response [inference]

humoral immune response [inference]

complement activation

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of immune effector process [inference]

regulation of complement activation

regulation of complement activation, alternative pathway

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of complement activation

regulation of complement activation, alternative pathway

regulation of innate immune response [inference]

regulation of complement activation, alternative pathway

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of innate immune response [inference]

regulation of complement activation, alternative pathway

regulation of response to external stimulus [inference]

regulation of innate immune response [inference]

regulation of complement activation, alternative pathway

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of complement activation

regulation of complement activation, alternative pathway

regulation of innate immune response [inference]

regulation of complement activation, alternative pathway

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of innate immune response [inference]

regulation of complement activation, alternative pathway

Displaying **all 3** entries
GO Term	Evidence Code	PMID
serine-type endopeptidase complex	ISO
symbiont cell surface	ISO
extracellular space	IBA IDA ISO	17028856

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

peptidase complex [inference]

serine-type peptidase complex [inference]

serine-type endopeptidase complex

endopeptidase complex [inference]

serine-type endopeptidase complex

cellular anatomical entity [inference]

extracellular space

other organism part [inference]

symbiont cell surface

Displaying **all 4** entries
GO Term	Evidence Code	PMID
heparin binding	IDA ISO	17028856
heparan sulfate proteoglycan binding	ISO
complement component C3b binding	IBA IPI	17028856
identical protein binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

opsonin binding [inference]

complement component C3b binding

complement binding [inference]

complement component C3b binding

identical protein binding

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

sulfur compound binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

complement factor H

Functional Category

M: Cell wall/membrane/envelope biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 2** entries
Gene Ontology
complement activation
complement component C3b binding

Displaying **all 2** entries
InterPro
Sushi/SCR/CCP domain
Sushi/SCR/CCP superfamily

Disease

Disease Ontology

Displaying entries **1 - 10** of 26 in total

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DO ID	Disease Name	Source
DOID:0060746	basal laminar drusen	Alliance of Genome Resources
DOID:0080162	lupus nephritis	Alliance of Genome Resources
DOID:0080301	atypical hemolytic-uremic syndrome	Alliance of Genome Resources
DOID:0080600	COVID-19	Alliance of Genome Resources
DOID:0110017	age related macular degeneration 4	Alliance of Genome Resources
DOID:10976	membranous glomerulonephritis	Alliance of Genome Resources
DOID:11335	sarcoidosis	Alliance of Genome Resources
DOID:12030	panuveitis	Alliance of Genome Resources
DOID:12554	hemolytic-uremic syndrome	Alliance of Genome Resources
DOID:12574	posterior uveitis	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 69 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Peromyscus maniculatus bairdii	102923317	230844_0:00553c
Peromyscus maniculatus bairdii	102925491	230844_0:003649
Ursus maritimus	103671020			URSMA30120
Nannospalax galili	103732851	1026970_0:001310
Serinus canaria	103815117			SERCA08111
Aotus nancymaae	105711745			AOTNA03397
Dipodomys ordii	105986399			DIPOR10154
Castor canadensis	109689621	51338_0:002220
Castor canadensis	109693057	51338_0:002c3e
Castor canadensis	109693060	51338_0:002c3f

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Last updated: December 9, 2024