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Rho GTPase activating protein 26

Summary

Gene Symbol

ARHGAP26

Organism

Homo sapiens (human)

External Links

NCBI Gene

23092

PubChem

23092

Alliance of Genome Resources

HGNC:17073

Annotation

Keyword

3D-structure
Alternative splicing
Cell junction
Chromosomal rearrangement
Cytoplasm
Cytoskeleton
Disease variant
Endosome
GTPase activation
Membrane
Phosphoprotein
Proto-oncogene
Reference proteome
SH3 domain

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9UNA1	GTPase regulator associated with focal adhesion kinase Oligophrenin-1-like protein Rho-type GTPase-activating protein 26
A0A0S2Z536	Rho-type GTPase-activating protein 26

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
mitophagy	IDA	38081847
signal transduction	IEA
actin cytoskeleton organization	NAS	11998687
regulation of small GTPase mediated signal transduction	TAS

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

autophagy [inference]

autophagy of mitochondrion [inference]

mitophagy

macroautophagy [inference]

mitophagy

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy [inference]

autophagy of mitochondrion [inference]

mitophagy

macroautophagy [inference]

mitophagy

cellular process [inference]

signal transduction

actin filament-based process [inference]

actin cytoskeleton organization

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy [inference]

autophagy of mitochondrion [inference]

mitophagy

macroautophagy [inference]

mitophagy

process utilizing autophagic mechanism [inference]

autophagy [inference]

autophagy of mitochondrion [inference]

mitophagy

macroautophagy [inference]

mitophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization [inference]

autophagy of mitochondrion [inference]

mitophagy

cytoskeleton organization [inference]

actin cytoskeleton organization

organelle disassembly [inference]

autophagy of mitochondrion [inference]

mitophagy

cellular component disassembly [inference]

organelle disassembly [inference]

autophagy of mitochondrion [inference]

mitophagy

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

regulation of cellular process [inference]

signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction

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GO Term	Evidence Code	PMID
mitochondrion	IDA	38081847
cytosol	TAS
cytosol	IDA	32344433
cytoskeleton	IEA
focal adhesion	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

endosome membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
GTPase activator activity	NAS	10908648
GTPase activator activity	TAS
GTPase activator activity	IBA
protein binding	IPI	11432776 25416956 26871637 32344433 32707033
phospholipid binding	IDA	18954304

GO Hierarchy

molecular function

binding [inference]

protein binding

lipid binding [inference]

phospholipid binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

GTPase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

rho gtpase-activating protein

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 8** entries
InterPro
AH/BAR domain superfamily
BAR domain
GRAF family
GRAF, PH domain
PH-like domain superfamily
Pleckstrin homology domain
Rho GTPase activation protein
Rho GTPase-activating protein domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050458	juvenile myelomonocytic leukemia	Alliance of Genome Resources
DOID:0081082	acute myelomonocytic leukemia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 85 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	4983	FB:FBgn0030685
Xenopus tropicalis	23092	Xenbase:XB-GENE-1011980
Mus musculus	71302	Xenbase:XB-GENE-1011980	MOUSE24062
Rattus norvegicus	307459		RATNO14127
Pan troglodytes	462160		PANTR36437
Canis lupus familiaris	478046		CANLF06670
Bos taurus	538219		BOVIN33649
Macaca mulatta	706084		MACMU38388
Monodelphis domestica	100023226		MONDO08927
Equus caballus	100072093		HORSE08056

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External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements