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fms related receptor tyrosine kinase 3 ligand

Summary

Gene Symbol

FLT3LG

Organism

Homo sapiens (human)

External Links

NCBI Gene

2323

PubChem

2323

Alliance of Genome Resources

HGNC:3766

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cytokine
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P49771	SL cytokine
B7ZLY4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
signal transduction	TAS	8180375
positive regulation of cell population proliferation	IDA	8180375
positive regulation of cell population proliferation	IBA
B cell differentiation	IMP	38701783
embryonic hemopoiesis	IDA	21149635

GO Hierarchy

biological process

immune system process [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell differentiation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell differentiation

signal transduction

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation

dendritic cell differentiation

cell development [inference]

hemopoiesis [inference]

embryonic hemopoiesis

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

B cell differentiation

B cell activation [inference]

B cell differentiation

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

hemopoiesis [inference]

embryonic hemopoiesis

animal organ development [inference]

embryonic organ development [inference]

embryonic hemopoiesis

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation

dendritic cell differentiation

cell development [inference]

hemopoiesis [inference]

embryonic hemopoiesis

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

regulation of cellular process [inference]

signal transduction

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	IBA
cytosol	TAS
plasma membrane	IEA
cell surface	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
signaling receptor binding	TAS	8180375
cytokine activity	IEA
protein binding	IPI	32296183 32814053
receptor tyrosine kinase binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

receptor tyrosine kinase binding

receptor ligand activity [inference]

cytokine activity

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

protein tyrosine kinase binding [inference]

receptor tyrosine kinase binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

fms-related tyrosine kinase 3 ligand

Functional Category

G: Carbohydrate transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
cytokine activity
kinase activity
phosphorylation
positive regulation of cell population proliferation
receptor tyrosine kinase binding

Displaying **all 2** entries
InterPro
Flt3 ligand
Four-helical cytokine-like, core

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:1520	colon carcinoma	Alliance of Genome Resources
DOID:3068	glioblastoma	Alliance of Genome Resources
DOID:3070	high grade glioma	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 28** of 28 in total

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Species	Gene ID	Orthologous MAtrix
Propithecus coquereli	105809290	PROCO22214
Rhinopithecus bieti	108535835	RHIBE19508
Vulpes vulpes	112931398	VULVU26819
Bos indicus x Bos taurus	113876197	BOBOX11454
Rhinolophus ferrumequinum	117034353	RHIFE00702
Balaenoptera musculus	118885012	BALMU16215
Panthera leo	122207913	PANLE28997
Ursus americanus	123776347	URSAM21171

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements