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alpha-2-macroglobulin

Summary

Gene Symbol

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

24153

PubChem

24153

Alliance of Genome Resources

RGD:2004

Annotation

Keyword

Acute phase
Bait region
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Serine protease inhibitor
Signal
Thioester bond

Proteins

Displaying 1 entry
UniProt	Protein Name
P06238

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
luteinization	IEP	2479532
negative regulation of complement activation, lectin pathway	ISO
acute inflammatory response to antigenic stimulus	IEP	6202298
acute-phase response	IEP	2468362
response to nutrient	IEP	9446838

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

inflammatory response to antigenic stimulus [inference]

acute inflammatory response to antigenic stimulus

cellular process [inference]

cellular developmental process [inference]

cell differentiation [inference]

stem cell differentiation

reproductive process [inference]

ovulation cycle process [inference]

luteinization

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

embryonic organ development [inference]

embryonic liver development

cellular developmental process [inference]

cell differentiation [inference]

stem cell differentiation

rhythmic process [inference]

ovulation cycle process [inference]

luteinization

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response [inference]

inflammatory response to antigenic stimulus [inference]

acute inflammatory response to antigenic stimulus

acute inflammatory response [inference]

immune response [inference]

inflammatory response to antigenic stimulus [inference]

acute inflammatory response to antigenic stimulus

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient

response to endogenous stimulus [inference]

response to hormone [inference]

response to prostaglandin [inference]

response to prostaglandin E

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to chemical [inference]

response to nutrient

response to organic substance [inference]

response to hormone [inference]

response to prostaglandin [inference]

response to prostaglandin E

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to carbon dioxide

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to lipid [inference]

response to prostaglandin [inference]

response to prostaglandin E

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to alcohol [inference]

response to prostaglandin E

response to ketone [inference]

response to prostaglandin E

response to oxygen-containing compound [inference]

response to carbon dioxide

response to alcohol [inference]

response to prostaglandin E

response to ketone [inference]

response to prostaglandin E

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

regulation of complement activation [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

regulation of immune response [inference]

regulation of humoral immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

regulation of complement activation [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

regulation of innate immune response [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of innate immune response [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of innate immune response [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of immune response [inference]

regulation of humoral immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

regulation of complement activation [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

regulation of innate immune response [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of complement activation [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of innate immune response [inference]

regulation of complement activation, lectin pathway [inference]

negative regulation of complement activation, lectin pathway

negative regulation of innate immune response [inference]

negative regulation of complement activation, lectin pathway

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular space	ISO
extracellular space	IDA	2442306
extracellular space	IBA
extracellular space	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
protease binding	ISO
protease binding	IBA
endopeptidase inhibitor activity	ISO
endopeptidase inhibitor activity	IDA	19240864
endopeptidase inhibitor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding

growth factor binding

interleukin-1 binding

neurotrophin binding [inference]

enzyme binding

protease binding

cytokine binding [inference]

chemokine binding [inference]

C-X-C chemokine binding [inference]

interleukin-8 binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Alpha-2-macroglobulin

Functional Category

O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying 1 entry
Gene Ontology
endopeptidase inhibitor activity

Displaying **all 4** entries
InterPro
Alpha-2-macroglobulin, bait region domain
Alpha-2-macroglobulin
Alpha-macroglobulin-like, TED domain
Immunoglobulin-like fold

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
extracellular space	PMID:2442306

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:14115	toxic shock syndrome	Alliance of Genome Resources
DOID:583	hemolytic anemia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 72 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	2	Xenbase:XB-GENE-481725	HUMAN11075
Xenopus tropicalis	17836	Xenbase:XB-GENE-481725
Xenopus tropicalis	17837	Xenbase:XB-GENE-481725
Xenopus tropicalis	24153	Xenbase:XB-GENE-481725
Mus musculus	232345	Xenbase:XB-GENE-481725	MOUSE50864
Danio rerio	232400	ZFIN:ZDB-GENE-131118-9
Xenopus tropicalis	252922	Xenbase:XB-GENE-481725
Sus scrofa	403166		PIGXX26223
Pan troglodytes	465372		PANTR05107
Canis lupus familiaris	477699		CANLF11090

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GlyComb

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OrthoDB (Group)

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Acknowledgements