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Alpha-2-macroglobulin

Summary

UniProt ID

P06238

Gene Symbol

A2m
A2m1

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: P06238

Annotation

Keyword

Acute phase
Bait region
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Serine protease inhibitor
Signal
Thioester bond

Gene Ontology (GO)

Displaying **all 10** entries
GO Term
stem cell differentiation
luteinization
negative regulation of complement activation, lectin pathway
acute inflammatory response to antigenic stimulus
acute-phase response
response to nutrient
response to prostaglandin E
response to glucocorticoid
embryonic liver development
response to carbon dioxide

Displaying 1 entry
GO Term
extracellular space

Displaying entries **1 - 10** of 13 in total

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GO Term
signaling receptor binding
interleukin-8 binding
brain-derived neurotrophic factor binding
protease binding
endopeptidase inhibitor activity
serine-type endopeptidase inhibitor activity
growth factor binding
enzyme binding
identical protein binding
interleukin-1 binding

Annotation information from UniProt.

Sequence

MGKHRLRSLALLPLLLRLLLLLLPTDASAPQKPIYMVMVPSLLHAGTPEKACFLFSHLNETVAVRVSLESVRGNQSLFTDLVVDKDLFHCTSFTVPQSSSDEVMFFTVQVKGATHEFRRRSTVLVKKKESLVFAQTDKPIYKPGQTVRFRVVSLDESFHPLNELIPLLYIQDPKNNRIAQWQNFNLEGGLKQLSFPLSSEPTQGSYKVVIRTESGRTVEHPFSVEEFVLPKFEVRVTVPETITILEEEMNVSVCGIYTYGKPVPGRVTVNICRKYSNPSNCFGEESVAFCEKLSQQLDGRGCFSQLVKTKSFQLKRQEYEMQLDVHAKIQEEGTGVEETGKGLTKITRTITKLSFVNVDSHFRQGIPFVGQVLLVDGRGTPIPYETIFIGADEANLYINTTTDKHGLARFSINTDDIMGTSLTVRAKYKDSNACYGFRWLTEENVEAWHTAYAVFSPSRSFLHLESLPDKLRCDQTLEVQAHYILNGEAMQELKELVFYYLMMAKGGIVRAGTHVLPLKQGQMRGHFSILISMETDLAPVARLVLYAILPNGEVVGDTAKYEIENCLANKVDLVFRPNSGLPATRALLSVMASPQSLCGLRAVDQSVLLMKPETELSASLIYDLLPVKDLTGFPQGADQREEDTNGCVKQNDTYINGILYSPVQNTNEEDMYGFLKDMGLKVFTNSNIRKPKVCERLRDNKGIPAAYHLVSQSHMDAFLESSESPTETRRSYFPETWIWDLVVVDSAGVAEVEVTVPDTITEWKAGAFCLSNDTGLGLSPVVQFQAFQPFFVELTMPYSVIRGEAFTLKATVLNYLPTCIRVAVQLEASPDFLAAPEEKEQRSHCICMNQRHTASWAVIPKSLGNVNFTVSAEALNSKELCGNEVPVVPEQGKKDTIIKSLLVEPEGLENEVTFNSLLCPMGAEVSELIALKLPSDVVEESARASVTVLGDILGSAMQNTQDLLKMPYGCGEQNMVLFAPNIYVLDYLNETQQLTQEIKTKAIAYLNTGYQRQLNYKHRDGSYSTFGDKPGRNHANTWLTAFVLKSFAQARKYIFIDEVHITQALLWLSQQQKDNGCFRSSGSLLNNAMKGGVEDEVTLSAYITIALLEMSLPVTHPVVRNALFCLDTAWKSARGGAGGSHVYTKALLAYAFALAGNQDTKKEILKSLDEEAVKEEDSVHWTRPQKPSVSVALWYQPQAPSAEVEMTAYVLLAYLTTEPAPTQEDLTAAMLIVKWLTKQQNSHGGFSSTQDTVVALHALSKYGSATFTRAKKAAQVTIHSSGTFSTKFQVNNNNQLLLQRVTLPTVPGDYTVKVTGEGCVYLQTSLKYSVLPREEEFPFTVVVQTLPGTCEDPKAHTSFQISLNISYTGSRSESNMAIADVKMVSGFIPLKPTVKMLERSVHVSRTEVSNNHVLIYLDKVSNQTVNLSFTVQQDIPIRDLKPAVVKVYDYYEKDEFAVAKYSAPCSTDYGNA

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 11 in total

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Position	Description	Source
59	N-linked (GlcNAc...) asparagine	UniProt
74	N-linked (GlcNAc...) asparagine	UniProt
250	N-linked (GlcNAc...) asparagine	UniProt
399	N-linked (GlcNAc...) asparagine	UniProt
651	N-linked (GlcNAc...) asparagine	UniProt
772	N-linked (GlcNAc...) asparagine	UniProt
867	N-linked (GlcNAc...) asparagine	UniProt
989	N-linked (GlcNAc...) asparagine	UniProt
1364	N-linked (GlcNAc...) asparagine	UniProt
1422	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Degradation of the extracellular matrix	Rattus norvegicus
HDL assembly	Rattus norvegicus
Intrinsic Pathway of Fibrin Clot Formation	Rattus norvegicus
Platelet degranulation	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements