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fucosyltransferase 3 (Lewis blood group)

Summary

Gene Symbol

FUT3

Aliases

CD174
galactoside 3(4)-L-fucosyltransferase

Organism

Homo sapiens (human)

External Links

NCBI Gene

2525

GGDB ID

gg003

HGNC

4014

mRNA

NM_000149

map

19p13.3

Protein

NP_000140

OMIM

111100

KEGG Gene ID

hsa:2525

PubChem

2525

Alliance of Genome Resources

HGNC:4014

Annotation

Keyword

Blood group antigen
Glycoprotein
Glycosyltransferase
Golgi apparatus
Lipid metabolism
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A8K737
P21217	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase Alpha-3-fucosyltransferase FUT3 Blood group Lewis alpha-4-fucosyltransferase Fucosyltransferase 3 Fucosyltransferase III

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
oligosaccharide biosynthetic process	IDA TAS	1977660
protein N-linked glycosylation	IDA	29593094
protein O-linked glycosylation	IDA	29593094
cell-cell recognition	IC	12668675
regulation of cell population proliferation	IMP	27453266

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

ceramide metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

biosynthetic process [inference]

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

glycosylation [inference]

fucosylation

macromolecule glycosylation

protein glycosylation [inference]

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

macromolecule glycosylation

protein glycosylation [inference]

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

cellular process [inference]

cell recognition [inference]

cell-cell recognition

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion

regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion

regulation of cell motility [inference]

regulation of cell migration

Displaying **all 4** entries
GO Term	Evidence Code	PMID
membrane	IDA	1977660
Golgi cisterna membrane	IEA
extracellular exosome	HDA	19199708
Golgi membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

Golgi cisterna membrane

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity	IDA IMP TAS	10211701 11058871 1740457 1977660 7721776
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	IDA IMP	10211701 11058871 12668675 1740457 1977660 29593094 7721776
alpha-(1->3)-fucosyltransferase activity	IBA IDA TAS	1977660
fucosyltransferase activity	IDA	12668675 7721776
protein binding	IPI	32296183

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

fucosyltransferase activity

3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity

alpha-(1->3)-fucosyltransferase activity

4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000171124

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg003

Gene Symbol

FUT3

Reactions

Displaying **all 5** entries
Donor	Acceptor	Product	Reference
GDP-Fuc	G40696TO	G00048MO	7721776
GDP-Fuc	G00055MO	G00051MO	7721776
GDP-Fuc	G61459JW	G00052MO	7721776
GDP-Fuc	G46776WR	G00053MO	7721776
GDP-Fuc	G00056MO	G39023AU	7721776

Displaying **all 9** entries
Donor	Acceptor	Product	Reference
GDP-Fuc	G61459JW	G00052MO	7721776 9079712
GDP-Fuc	G03499BP	G08176ZW	9079712
GDP-Fuc	G51162XR	G38421BP
GDP-Fuc	G00055MO	G00051MO	7721776
GDP-Fuc	G40696TO	G00048MO	7721776 9079712
GDP-Fuc	G11647UD	G00371DJ
GDP-Fuc	G46776WR	G00053MO	7721776
GDP-Fuc	G03975EI	G43438SM
GDP-Fuc	G00056MO	G39023AU	7721776

Orthologous Gene

Displaying 1 entry
Species	Protein	mRNA
Caenorhabditis elegans	NP_495106	NM_062705

KEGG BRITE Database

Orthology

K00716

Name

galactoside 3(4)-fucosyltransferase 3 [EC:2.4.1.65]

References

1977660

Reactions

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KEGG Reaction	Enzyme	Acceptor	Product
R06230	2.4.1.- 2.4.1.152 2.4.1.65	G84034JH	G65223RT
R06227	2.4.1.- 2.4.1.152 2.4.1.65	G07075ZE	G03564IA
R06075	2.4.1.- 2.4.1.65	G01767JJ	G96401FK
R06155	2.4.1.65	G00049MO	G26123AX
R06038	2.4.1.- 2.4.1.152 2.4.1.65	G84034JH	G76439VL
R13173	2.4.1.65	G96538JO	G72748AQ
R06165	2.4.1.65	G79536OW	G50321QR
R06039	2.4.1.- 2.4.1.152 2.4.1.65	G77285LE	G00851XQ
R06162	2.4.1.65	G82858KU	G71485PH
R06025	2.4.1.- 2.4.1.152 2.4.1.65	G58896AZ	G72002FC

Rhea

RHEA:14257

a β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl derivative + GDP-β-L-fucose

a β-D-galactosyl-(1→4)-[α-L-fucosyl-(1→3)]-N-acetyl-β-D-glucosaminyl derivative + H⁺ + GDP

Enzyme

2.4.1.152

PMID

RHEA:23628

a β-D-galactosyl-(1→3)-N-acetyl-β-D-glucosaminyl derivative + GDP-β-L-fucose

a β-D-galactosyl-(1→3)-[α-L-fucosyl-(1→4)]-N-acetyl-β-D-glucosaminyl derivative + H⁺ + GDP

Enzyme

2.4.1.65

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 88 in total

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DO ID	Disease Name	Source
DOID:12930	dilated cardiomyopathy	DisGeNET
DOID:0050387	nonpapillary renal cell carcinoma	DisGeNET
DOID:0050589	inflammatory bowel disease	DisGeNET DisGeNET
DOID:0050819	obsolete Matthew-Wood syndrome	DisGeNET
DOID:0060025	immunoglobulin alpha deficiency	DisGeNET
DOID:0060180	colitis	DisGeNET
DOID:0060189	ileitis	DisGeNET
DOID:0060190	ileocolitis	DisGeNET
DOID:0060192	Crohn's colitis	DisGeNET
DOID:0060643	primary sclerosing cholangitis	DisGeNET

PubChem Disease

MedGen Diseases

Blood group, lewis system

OMIM Phenotypes

BLOOD GROUP, LEWIS SYSTEM; LE

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of 29 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	174400	WB:WBGene00001505
Caenorhabditis elegans	187342	WB:WBGene00001507
Drosophila melanogaster	39653	FB:FBgn0036485
Xenopus laevis	399050	Xenbase:XB-GENE-5889338
Xenopus tropicalis	447987	Xenbase:XB-GENE-5889327
Xenopus tropicalis	100127585	Xenbase:XB-GENE-5886482
Xenopus tropicalis	100335051	Xenbase:XB-GENE-5772160
Xenopus tropicalis	100495376	Xenbase:XB-GENE-6037628
Meleagris gallopavo	100544367		MELGA09441
Macaca fascicularis	102145756		MACFA16979

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements