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Repository for lectin-assisted multimodality data

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Tools

Glycan Converters

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Guidelines

MIRAGE

pregnancy-zone protein

Summary

Gene Symbol

Pzp

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

252922

PubChem

252922

Alliance of Genome Resources

RGD:628643

Annotation

Keyword

3D-structure
Bait region
Direct protein sequencing
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Serine protease inhibitor
Signal
Thioester bond

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6IM16
Q63041	Alpha-1-macroglobulin 165 kDa subunit

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
embryo implantation	IEA
negative regulation of peptidase activity

GO Hierarchy

biological process

reproductive process [inference]

embryo implantation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

Displaying 1 entry
GO Term	Evidence Code	PMID
extracellular space	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

Displaying entries **1 - 5** of 6 in total

1

2

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GO Term	Evidence Code	PMID
protease binding	IBA
endopeptidase inhibitor activity	IBA
serine-type endopeptidase inhibitor activity	IEA
protein-containing complex binding	IPI	2470410
brain-derived neurotrophic factor binding	IDA	11813239

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

growth factor binding [inference]

neurotrophin binding [inference]

enzyme binding [inference]

protease binding

protein-containing complex binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

alpha-2-macroglobulin

Functional Category

O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying 1 entry
Gene Ontology
endopeptidase inhibitor activity

Displaying **all 4** entries
InterPro
Alpha-2-macroglobulin, bait region domain
Alpha-2-macroglobulin
Immunoglobulin E-set
Immunoglobulin-like fold

Ortholog

Displaying entries **1 - 10** of 26 in total

1

2

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	2	Xenbase:XB-GENE-921402
Mus musculus	11287		MOUSE49075
Xenopus tropicalis	17836	Xenbase:XB-GENE-921402
Xenopus tropicalis	17837	Xenbase:XB-GENE-921402
Xenopus tropicalis	24153	Xenbase:XB-GENE-481725
Xenopus tropicalis	232345	Xenbase:XB-GENE-921402
Danio rerio	232400	ZFIN:ZDB-GENE-131118-9
Xenopus tropicalis	252922	Xenbase:XB-GENE-921402
Xenopus tropicalis	497794	Xenbase:XB-GENE-481725
Canis lupus familiaris	611458		CANLF11089

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025