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fucosyltransferase 8

Summary

Gene Symbol

FUT8

Aliases

alpha (1,6) fucosyltransferase

Organism

Homo sapiens (human)

External Links

NCBI Gene

2530

GGDB ID

gg009

HGNC

4019

mRNA

NM_178154

map

14q24.3

Protein

NP_835367

OMIM

602589

KEGG Gene ID

hsa:2530

PubChem

2530

Alliance of Genome Resources

HGNC:4019

Annotation

Keyword

3D-structure
Alternative splicing
Coiled coil
Congenital disorder of glycosylation
Disease variant
Disulfide bond
Glycosyltransferase
Golgi apparatus
Phosphoprotein
Reference proteome
SH3 domain
SH3-binding
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q546E0
Q9BYC5	Fucosyltransferase 8 GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase GDP-fucose--glycoprotein fucosyltransferase Glycoprotein 6-alpha-L-fucosyltransferase
A8K8P8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 16 in total

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GO Term	Evidence Code	PMID
integrin-mediated signaling pathway	IEA
N-glycan fucosylation	IBA
regulation of gene expression	IEA
regulation of cellular response to oxidative stress	IEA
viral protein processing	TAS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

catabolic process [inference]

small molecule catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

biosynthetic process [inference]

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

phosphorus metabolic process [inference]

GDP-L-fucose metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

L-fucose metabolic process [inference]

L-fucose catabolic process

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

L-fucose metabolic process [inference]

L-fucose catabolic process

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

small molecule catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

glycosylation [inference]

fucosylation [inference]

N-glycan fucosylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

L-fucose metabolic process [inference]

L-fucose catabolic process

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

receptor metabolic process

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

fucose catabolic process [inference]

L-fucose catabolic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

integrin-mediated signaling pathway

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

phosphorus metabolic process [inference]

GDP-L-fucose metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

fibroblast migration

viral process [inference]

viral protein processing

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

respiratory gaseous exchange by respiratory system

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of response to stimulus [inference]

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of cellular response to oxidative stress

regulation of response to oxidative stress [inference]

regulation of cellular response to oxidative stress

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

integrin-mediated signaling pathway

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cellular response to stress [inference]

regulation of cellular response to oxidative stress

Displaying **all 5** entries
GO Term	Evidence Code	PMID
membrane	HDA	19946888
Golgi apparatus	NAS	11698403
Golgi cisterna membrane	IEA
extracellular exosome	HDA	19199708
Golgi membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

Golgi cisterna membrane

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

Golgi apparatus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
alpha-(1->6)-fucosyltransferase activity	IBA
glycoprotein 6-alpha-L-fucosyltransferase activity	IDA TAS	11698403 17172260
protein binding	IPI	32296183
SH3 domain binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

fucosyltransferase activity [inference]

alpha-(1->6)-fucosyltransferase activity

glycoprotein 6-alpha-L-fucosyltransferase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

glycoprotein 6-alpha-L-fucosyltransferase activity

binding [inference]

protein binding

protein domain specific binding [inference]

SH3 domain binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000033170

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg009

Gene Symbol

FUT8

Reactions

Displaying 1 entry
Donor	Acceptor	Product	Reference
GDP-Fuc	G39213VZ	G80858MF	1939186

Orthologous Gene

Displaying **all 4** entries
Species	Protein	mRNA
Rattus norvegicus	NP_001002289	NM_001002289
Drosophila melanogaster	NP_572740	NM_132512
Caenorhabditis elegans	NP_504555	NM_072154
Mus musculus	NP_058589	NM_016893

KEGG BRITE Database

Orthology

K00717

Name

glycoprotein 6-alpha-L-fucosyltransferase [EC:2.4.1.68]

References

8910378

Reactions

Displaying **all 2** entries
KEGG Reaction	Enzyme	Acceptor	Product
R09319	2.4.1.68	G61751GZ	G07483YN
R05988	2.4.1.68	G39213VZ	G80858MF

Rhea

RHEA:12985

GDP-β-L-fucose

H⁺ + GDP

Enzyme

2.4.1.68

PMID

Disease

Disease Ontology

Displaying entries **41 - 50** of 65 in total

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DO ID	Disease Name	Source
DOID:3905	lung carcinoma	DisGeNET DisGeNET
DOID:3908	lung non-small cell carcinoma	DisGeNET
DOID:4001	ovarian carcinoma	DisGeNET DisGeNET
DOID:4480	achondroplasia	DisGeNET
DOID:4766	embryoma	DisGeNET
DOID:5162	arteriolosclerosis	DisGeNET DisGeNET
DOID:5212	congenital disorder of glycosylation	DisGeNET
DOID:5403	microcystic adenoma	DisGeNET
DOID:5419	schizophrenia	DisGeNET
DOID:5672	large intestine cancer	DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 33 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000121	Nephrocalcinosis
HP:0000218	High palate
HP:0000252	Microcephaly
HP:0000278	Retrognathia
HP:0000337	Broad forehead
HP:0000341	Narrow forehead
HP:0000348	High forehead
HP:0000431	Wide nasal bridge
HP:0000501	Glaucoma

Displaying 1 entry
Disease ID	Disease Name
OMIM:618005	congenital disorder of glycosylation with defective fucosylation 1

PubChem Disease

MedGen Diseases

Congenital disorder of glycosylation with defective fucosylation 1

OMIM Phenotypes

CONGENITAL DISORDER OF GLYCOSYLATION WITH DEFECTIVE FUCOSYLATION 1; CDGF1

KEGG Diseases

Congenital disorder of glycosylation with defective fucosylation

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	178985	WB:WBGene00001508
Drosophila melanogaster	32122	FB:FBgn0030327
Callorhinchus milii	103175217		CALMI07240
Latimeria chalumnae	102348117		LATCH16700
Lepisosteus oculatus	102695396		LEPOC15835
Danio rerio	797512	ZFIN:ZDB-GENE-031118-20	DANRE12812
Danio rerio	100331714	ZFIN:ZDB-GENE-130530-923	DANRE20246
Astyanax mexicanus	103043605		ASTMX03282
Ictalurus punctatus	108257543		ICTPU20510
Ictalurus punctatus	108270174		ICTPU35020

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Other Information

Tools

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Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements