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atypical chemokine receptor 1 (Duffy blood group)

Summary

Gene Symbol

ACKR1

Organism

Homo sapiens (human)

External Links

NCBI Gene

2532

PubChem

2532

Alliance of Genome Resources

HGNC:4035

Annotation

Keyword

3D-structure
Alternative splicing
Blood group antigen
Direct protein sequencing
Disulfide bond
Endosome
G-protein coupled receptor
Glycoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q5Y7A1	Duffy antigen/chemokine receptor
Q5Y7A2	Duffy antigen/chemokine receptor
Q16570	Duffy antigen/chemokine receptor Fy glycoprotein Glycoprotein D Plasmodium vivax receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
defense response	NAS	10570183
chemokine-mediated signaling pathway	IEA
regulation of chemokine production	IBA
inflammatory response	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway

response to stimulus [inference]

response to stress [inference]

defense response

inflammatory response

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of chemokine production

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of chemokine production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of chemokine production

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of chemokine production

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

regulation of chemokine production

Displaying **all 3** entries
GO Term	Evidence Code	PMID
recycling endosome	IEA
early endosome	IEA
plasma membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	18230715 21743458
signaling receptor activity	TAS	7689250
G protein-coupled receptor activity	IEA
C-C chemokine binding	IBA IPI	7517217
transmembrane signaling receptor activity	TAS	9058825

GO Hierarchy

molecular function

binding [inference]

protein binding

cytokine binding [inference]

chemokine binding [inference]

C-C chemokine binding

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity

G protein-coupled receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

atypical chemokine receptor 1

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
C-C chemokine binding
chemokine binding
chemokine-mediated signaling pathway
inflammatory response

Displaying 1 entry
InterPro
Duffy antigen/chemokine receptor

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:12365	malaria	Alliance of Genome Resources
DOID:12978	Plasmodium vivax malaria	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 46 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Nomascus leucogenys	100579790		NOMLE04071
Loxodonta africana	100662964		LOXAF09520
Cricetulus griseus	100757110		CRIGR07203
Canis lupus familiaris	100856110		CANLF14467
Sarcophilus harrisii	100920730		SARHA15381
Pan paniscus	100976602	9597_0:000610	PANPA02837
Saimiri boliviensis boliviensis	101050599		SAIBB29260
Felis catus	101094569		FELCA37323
Ovis aries	101113185		SHEEP01027
Gorilla gorilla gorilla	101153049	9595_0:0005e6	GORGO20098

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements