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atypical chemokine receptor 1 (Duffy blood group)

Summary

Gene Symbol

ACKR1

Organism

Homo sapiens (human)

External Links

NCBI Gene

2532

PubChem

2532

Alliance of Genome Resources

HGNC:4035

Annotation

Keyword

3D-structure
Alternative splicing
Blood group antigen
Direct protein sequencing
Disulfide bond
Endosome
G-protein coupled receptor
Glycoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q5Y7A1	Duffy antigen/chemokine receptor
Q5Y7A2	Duffy antigen/chemokine receptor
Q16570	Duffy antigen/chemokine receptor Fy glycoprotein Glycoprotein D Plasmodium vivax receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
defense response	NAS	10570183
chemokine-mediated signaling pathway	IEA
regulation of chemokine production	IBA
inflammatory response	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway

response to stimulus [inference]

response to stress [inference]

defense response

inflammatory response

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of chemokine production

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of chemokine production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of chemokine production

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of chemokine production

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

regulation of chemokine production

Displaying **all 3** entries
GO Term	Evidence Code	PMID
recycling endosome	IEA
early endosome	IEA
plasma membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	18230715 21743458
signaling receptor activity	TAS	7689250
G protein-coupled receptor activity	IEA
C-C chemokine binding	IBA IPI	7517217
transmembrane signaling receptor activity	TAS	9058825

GO Hierarchy

molecular function

binding [inference]

protein binding

cytokine binding [inference]

chemokine binding [inference]

C-C chemokine binding

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity

G protein-coupled receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

atypical chemokine receptor 1

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
C-C chemokine binding
chemokine binding
chemokine-mediated signaling pathway
inflammatory response

Displaying 1 entry
InterPro
Duffy antigen/chemokine receptor

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:12365	malaria	Alliance of Genome Resources
DOID:12978	Plasmodium vivax malaria	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 46 in total

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Species	Gene ID	Orthologous MAtrix
Mandrillus leucophaeus	105538775	MANLE37387
Cercocebus atys	105601251	CERAT43437
Aotus nancymaae	105715398	AOTNA24720
Propithecus coquereli	105824442	PROCO15221
Dipodomys ordii	105996464	DIPOR18518
Equus asinus asinus	106835735	EQUAS27367
Phascolarctos cinereus	110201857	PHACI17529
Vulpes vulpes	112910130	VULVU36294
Podarcis muralis	114586771	PODMU28392
Taeniopygia guttata	115498419	TAEGU14257

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements