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peptidylglycine alpha-amidating monooxygenase

Summary

Gene Symbol

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

25508

PubChem

25508

Alliance of Genome Resources

RGD:3252

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Cleavage on pair of basic residues
Copper
Cytoplasmic vesicle
Direct protein sequencing
Disulfide bond
Glycoprotein
Lipid metabolism
Lyase
Metal-binding
Monooxygenase
Multifunctional enzyme
Phosphoprotein
Reference proteome
Repeat
Signal
Sulfation
Transmembrane helix
Vitamin C
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P14925
A6JR60

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
peptide amidation	ISO
peptide amidation	IDA	10079066 2999151
peptide amidation	IEA
response to hypoxia	IEP	18818385
long-chain fatty acid metabolic process	IDA	8660675

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

fatty acid primary amide biosynthetic process

amide metabolic process [inference]

peptide metabolic process

peptide modification [inference]

peptide amidation

amide biosynthetic process [inference]

fatty acid primary amide biosynthetic process

fatty acid primary amide metabolic process [inference]

fatty acid primary amide biosynthetic process

organonitrogen compound metabolic process [inference]

peptide metabolic process

peptide modification [inference]

peptide amidation

fatty acid primary amide metabolic process [inference]

fatty acid primary amide biosynthetic process

organonitrogen compound biosynthetic process [inference]

fatty acid primary amide biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

fatty acid primary amide biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

fatty acid primary amide biosynthetic process

organonitrogen compound biosynthetic process [inference]

fatty acid primary amide biosynthetic process

secondary metabolic process [inference]

toxin metabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

toxin metabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

fatty acid primary amide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

fatty acid primary amide biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

fatty acid primary amide biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

fatty acid derivative metabolic process [inference]

fatty acid primary amide metabolic process [inference]

fatty acid primary amide biosynthetic process

fatty acid derivative biosynthetic process [inference]

fatty acid primary amide biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

fatty acid primary amide biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

fatty acid derivative metabolic process [inference]

fatty acid primary amide metabolic process [inference]

fatty acid primary amide biosynthetic process

fatty acid derivative biosynthetic process [inference]

fatty acid primary amide biosynthetic process

organonitrogen compound metabolic process [inference]

peptide metabolic process

peptide modification [inference]

peptide amidation

fatty acid primary amide metabolic process [inference]

fatty acid primary amide biosynthetic process

organonitrogen compound biosynthetic process [inference]

fatty acid primary amide biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

fatty acid primary amide biosynthetic process

organonitrogen compound biosynthetic process [inference]

fatty acid primary amide biosynthetic process

cellular process [inference]

cell cycle process [inference]

mitotic cell cycle process [inference]

mitotic chromosome condensation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

toxin metabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

fatty acid primary amide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

fatty acid primary amide biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

chromosome condensation [inference]

mitotic chromosome condensation

reproductive process [inference]

ovulation cycle process

multicellular organismal reproductive process [inference]

maternal process involved in female pregnancy

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

heart development

appendage development [inference]

limb development

rhythmic process [inference]

ovulation cycle process

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to abiotic stimulus [inference]

response to pH

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to chemical [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to organic cyclic compound [inference]

response to estradiol

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to lipid [inference]

response to estradiol

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to inorganic substance [inference]

response to metal ion [inference]

response to oxygen-containing compound [inference]

response to estradiol

localization [inference]

establishment of localization [inference]

transport [inference]

secretion [inference]

body fluid secretion [inference]

lactation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization

regulation of biological quality [inference]

regulation of body fluid levels [inference]

body fluid secretion [inference]

lactation

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
chromatin	ISO
condensed chromosome	ISO
extracellular region	IBA
extracellular space	IDA	16448835
trans-Golgi network	IDA	20573687

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-DNA complex [inference]

chromatin

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane

bounding membrane of organelle [inference]

transport vesicle membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome [inference]

condensed chromosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

intracellular non-membrane-bounded organelle [inference]

chromosome [inference]

condensed chromosome

cell body [inference]

neuronal cell body

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
chromatin binding	ISO
peptidylglycine monooxygenase activity	ISO
peptidylglycine monooxygenase activity	IDA	10079066 16405966
peptidylglycine monooxygenase activity	IBA
peptidylglycine monooxygenase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

peptidylglycine monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

peptidylglycine monooxygenase activity

lyase activity

carbon-nitrogen lyase activity [inference]

amidine-lyase activity [inference]

peptidylamidoglycolate lyase activity

catalytic activity, acting on a protein [inference]

peptidylamidoglycolate lyase activity

binding [inference]

protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

identical protein binding

carbohydrate binding [inference]

monosaccharide binding [inference]

L-ascorbic acid binding

small molecule binding [inference]

vitamin binding [inference]

L-ascorbic acid binding

organic acid binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

monosaccharide binding [inference]

L-ascorbic acid binding

heterocyclic compound binding [inference]

L-ascorbic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

cation binding [inference]

metal ion binding [inference]

calcium ion binding

transition metal ion binding [inference]

protein-containing complex binding [inference]

chromatin binding

organic cyclic compound binding [inference]

L-ascorbic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Peptidyl-glycine alpha-amidating monooxygenase

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 7** entries
Gene Ontology
catalytic activity
copper ion binding
metal ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
peptide metabolic process
peptidylglycine monooxygenase activity

Displaying **all 8** entries
InterPro
Copper type II ascorbate-dependent monooxygenase, C-terminal
Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily
Copper type II, ascorbate-dependent monooxygenase, N-terminal
Copper type II, ascorbate-dependent monooxygenase-like, C-terminal
NHL repeat
PHM/PNGase F domain superfamily
Peptidylglycine alpha-hydroxylating monooxygenase/peptidyl-hydroxyglycine alpha-amidating lyase
Six-bladed beta-propeller, TolB-like

Alliance of Genome Resources

Expression

Displaying **all 7** entries
Location	References
perikaryon	PMID:8910496
neuronal cell body	PMID:20202202
secretory granule	PMID:15539631
extracellular space	PMID:16448835
perinuclear region of cytoplasm	PMID:8663411
trans-Golgi network	PMID:20573687
cell surface	PMID:15905171

Ortholog

Displaying entries **1 - 10** of 87 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	5066	Xenbase:XB-GENE-950935	HUMAN80199
Mus musculus	18484	Xenbase:XB-GENE-950935	MOUSE30132
Xenopus tropicalis	25508	Xenbase:XB-GENE-950935
Xenopus tropicalis	36033	Xenbase:XB-GENE-950935
Danio rerio	172108	ZFIN:ZDB-GENE-090313-384
Bos taurus	280890		BOVIN34034
Xenopus tropicalis	379207	Xenbase:XB-GENE-950935
Xenopus tropicalis	397736	Xenbase:XB-GENE-950935
Pan troglodytes	461974		PANTR35852
Danio rerio	570822	Xenbase:XB-GENE-950935	DANRE00295

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External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements