SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
| GO Term | Evidence Code | PMID |
|---|---|---|
| regulation of innate immune response | ||
| regulation of innate immune response | ||
| dATP catabolic process | ||
| protein homotetramerization | ||
| defense response to virus |
| GO Term | Evidence Code | PMID |
|---|---|---|
| nucleus | ||
| nucleus | ||
| nucleoplasm | ||
| nucleoplasm | ||
| plasma membrane |
| GO Term | Evidence Code | PMID |
|---|---|---|
| nucleic acid binding | ||
| single-stranded DNA binding | ||
| RNA binding | ||
| RNA nuclease activity | ||
| protein binding |
| Gene Ontology |
|---|
| 'de novo' IMP biosynthetic process |
| nucleotide binding |
| phosphoribosylaminoimidazolesuccinocarboxamide synthase activity |
| purine nucleotide biosynthetic process |
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050629 | Aicardi-Goutieres syndrome | |
| DOID:0060386 | Chilblain lupus | |
| DOID:1883 | hepatitis C | |
| DOID:2043 | hepatitis B | |
| DOID:9119 | acute myeloid leukemia |
| HPO ID | HPO Term |
|---|---|
| HP:0004374 | Hemiplegia/hemiparesis |
| HP:0004809 | Neonatal alloimmune thrombocytopenia |
| HP:0004942 | Aortic aneurysm |
| HP:0004963 | Calcification of the aorta |
| HP:0005550 | Chronic lymphatic leukemia |
| HP:0006579 | Prolonged neonatal jaundice |
| HP:0007052 | Multifocal cerebral white matter abnormalities |
| HP:0007076 | Extrapyramidal muscular rigidity |
| HP:0007108 | Demyelinating peripheral neuropathy |
| HP:0007229 | Intracerebral periventricular calcifications |
| Disease ID | Disease Name |
|---|---|
| OMIM:614415 |
|
| OMIM:612952 |
|
| ORPHA:51 |
|
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 25939 | Xenbase:XB-GENE-976503 | ||
| 56045 | MOUSE33048 | ||
| 311580 | RATNO26819 | ||
| 458223 | PANTR24808 | ||
| 485862 | CANLF09514 | ||
| 524683 | BOVIN05214 | ||
| 553453 | DANRE24335 | ||
| 709060 | MACMU01455 | ||
| 100032613 | MONDO07533 | ||
| 100069764 | HORSE21662 |
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Supported by JST NBDC Grant Number JPMJND2204
Partly supported by NIH Common Fund Grant #1U01GM125267-01
This work is licensed under Creative Commons Attribution 4.0 International
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Last updated: December 8, 2025