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beta-1,4-galactosyltransferase 1

Summary

Gene Symbol

B4GALT1

Aliases

Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
N-acetyllactosamine synthase
beta4Gal-T1
lactose synthase A

Organism

Homo sapiens (human)

External Links

NCBI Gene

2683

GGDB ID

gg077

HGNC

924

mRNA

NM_001497

map

9p13

Protein

NP_001488

OMIM

137060

KEGG Gene ID

hsa:2683

PubChem

2683

Alliance of Genome Resources

HGNC:924

Annotation

Keyword

3D-structure
Alternative initiation
Cell membrane
Cell projection
Congenital disorder of glycosylation
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Lipid metabolism
Manganese
Metal-binding
Reference proteome
Secreted
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P15291	Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase Lactose synthase A protein N-acetyllactosamine synthase Nal synthase Neolactotriaosylceramide beta-1,4-galactosyltransferase UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1 UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 22 in total

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GO Term	Evidence Code	PMID
protein N-linked glycosylation	IBA
lipid metabolic process	IMP	34855475
cell adhesion	IEA
binding of sperm to zona pellucida	IEA
penetration of zona pellucida	IEA

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration [inference]

myeloid leukocyte migration [inference]

macrophage migration

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

biosynthetic process [inference]

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

galactose metabolic process

oligosaccharide metabolic process [inference]

disaccharide metabolic process [inference]

lactose metabolic process [inference]

lactose biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

oligosaccharide biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

lipid metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

galactose metabolic process

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

galactose metabolic process

oligosaccharide metabolic process [inference]

disaccharide metabolic process [inference]

lactose metabolic process [inference]

lactose biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

oligosaccharide biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

lipid metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

disaccharide biosynthetic process [inference]

lactose biosynthetic process

cellular process [inference]

cell adhesion

cell recognition [inference]

cell-cell recognition [inference]

sperm-egg recognition [inference]

binding of sperm to zona pellucida

cell population proliferation [inference]

epithelial cell proliferation

cellular developmental process [inference]

cell development [inference]

epithelial cell development

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

myeloid leukocyte migration [inference]

macrophage migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

reproductive process [inference]

developmental process involved in reproduction [inference]

development of secondary sexual characteristics

sperm-egg recognition [inference]

binding of sperm to zona pellucida

multicellular organismal reproductive process [inference]

penetration of zona pellucida

multicellular organismal process [inference]

multi-multicellular organism process [inference]

penetration of zona pellucida

developmental process [inference]

developmental process involved in reproduction [inference]

development of secondary sexual characteristics

anatomical structure formation involved in morphogenesis [inference]

angiogenesis [inference]

angiogenesis involved in wound healing

anatomical structure development [inference]

cell development [inference]

epithelial cell development

cellular developmental process [inference]

cell development [inference]

epithelial cell development

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response [inference]

acute inflammatory response

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation involved in wound healing

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation involved in wound healing

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation

regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation involved in wound healing

negative regulation of epithelial cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation involved in wound healing

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation

regulation of reproductive process [inference]

regulation of acrosome reaction

regulation of biological quality [inference]

regulation of circulating fibrinogen levels [inference]

positive regulation of circulating fibrinogen levels

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GO Term	Evidence Code	PMID
Golgi trans cisterna	IDA	6121819
Golgi membrane	TAS
extracellular space	HDA	16502470
Golgi apparatus	IDA	10900002 7744867
Golgi apparatus	IBA

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

extracellular space

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane

azurophil granule membrane

Golgi cisterna membrane

bounding membrane of organelle [inference]

Golgi membrane

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane [inference]

azurophil granule membrane

secretory granule membrane

azurophil granule membrane

plasma membrane region [inference]

basolateral plasma membrane

cell projection membrane [inference]

brush border membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

desmosome

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

Golgi cisterna [inference]

Golgi trans cisterna

cell projection [inference]

plasma membrane bounded cell projection [inference]

actin-based cell projection [inference]

filopodium

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

Golgi apparatus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

external side of plasma membrane

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GO Term	Evidence Code	PMID
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	TAS
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	IDA	16157350 33805
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	IMP	34855475
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	IBA
N-acetyllactosamine synthase activity	IDA	2120039 33805

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

UDP-galactosyltransferase activity

hexosyltransferase activity [inference]

galactosyltransferase activity

UDP-galactosyltransferase activity

binding [inference]

protein binding [inference]

cytoskeletal protein binding

tubulin binding [inference]

identical protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

manganese ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Beta-1,4-galactosyltransferase 4

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
galactosyltransferase activity
glycosylation
metal ion binding
transferase activity

Displaying **all 4** entries
InterPro
Beta-1,4-galactosyltransferase
Galactosyltransferase, C-terminal
Galactosyltransferase, N-terminal
Nucleotide-diphospho-sugar transferases

Human Protein Atlas

ENSG00000086062

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg077

Gene Symbol

B4GALT1

Reactions

Displaying **all 2** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-Gal	G49108TO	R	G00055MO	R	3014508
UDP-Glc	G49108TO	R	G38884XS	R	11485999

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Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-Gal	G23438NR	O-glycan Synthesis	G07932PU	O-glycan Synthesis
UDP-Gal	G82440PA	octyl	G00887EN	octyl	9857011
UDP-Glc	G49108TO	R	G38884XS	R	11485999

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Donor	Acceptor	Reducing terminal(Acceptor)
UDP-Gal	G32723SL	O-glycan Synthesis
UDP-Gal	G41245OZ	O-glycan Synthesis
UDP-Gal	G17752YB	O-glycan Synthesis
UDP-Gal	G02522JF	O-glycan Synthesis
UDP-Gal	G11457RF	O-glycan Synthesis

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Mus musculus	NP_071641	NM_022305
Rattus norvegicus	XP_342821	XM_342821

KEGG BRITE Database

Orthology

K07966

Name

beta-1,4-galactosyltransferase 1 [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-]

References

Reactions

Displaying **all 4** entries
KEGG Reaction	Enzyme	Acceptor	Product
R07617	2.4.1.-	G00033MO	G64973KT
R06033	2.4.1.-	G70874WW	G84034JH
R05989	2.4.1.38	G80858MF	G78059CC
R05977	2.4.1.- 2.4.1.275	G06239NA	G58896AZ

Rhea

RHEA:31499

a β-D-GlcNAc-(1→3)-β-D-Gal-(1→4)-β-D-Glc-(1↔1)-Cer(d18:1(4E)) + UDP-α-D-galactose

H⁺ + a neolactoside nLc4Cer(d18:1(4E)) + UDP

Enzyme

2.4.1.275

PMID

RHEA:22932

an N-acetyl-β-D-glucosaminyl derivative + UDP-α-D-galactose

a β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl derivative + H⁺ + UDP

Enzyme

2.4.1.38

PMID

RHEA:12404

D-glucose + UDP-α-D-galactose

H⁺ + lactose + UDP

Enzyme

2.4.1.22

PMID

RHEA:17745

N-acetyl-D-glucosamine + UDP-α-D-galactose

H⁺ + UDP + β-D-galactosyl-(1→4)-N-acetyl-D-glucosamine

Enzyme

2.4.1.90

PMID

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0070256	congenital disorder of glycosylation type IId	Glyco-Disease Genes Database Alliance of Genome Resources
DOID:5212	congenital disorder of glycosylation	Alliance of Genome Resources

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0001999	Abnormal facial shape
HP:0002014	Diarrhea
HP:0002240	Hepatomegaly
HP:0002910	Elevated circulating hepatic transaminase concentration
HP:0003160	Abnormal isoelectric focusing of serum transferrin
HP:0003186	Inverted nipples
HP:0003198	Myopathy
HP:0003199	Decreased muscle mass
HP:0003236	Elevated circulating creatine kinase concentration
HP:0003256	Abnormality of the coagulation cascade

Displaying **all 3** entries
Disease ID	Disease Name
OMIM:620364	combined low LDL and fibrinogen
ORPHA:79332	B4GALT1-congenital disorder of glycosylation
OMIM:607091	B4GALT1-congenital disorder of glycosylation

PubChem Disease

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Congenital disorders of glycosylation type II

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002816
Gene Name: UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	2683	Xenbase:XB-GENE-5871724
Drosophila melanogaster	8702	FB:FBgn0027538
Drosophila melanogaster	8703	FB:FBgn0027538
Drosophila melanogaster	8704	FB:FBgn0027538
Drosophila melanogaster	9334	FB:FBgn0027538
Mus musculus	14595	Xenbase:XB-GENE-5871724	MOUSE42593
Rattus norvegicus	24390	Xenbase:XB-GENE-1015082	RATNO32617
Xenopus tropicalis	36585	Xenbase:XB-GENE-5871724
Drosophila melanogaster	53418	FB:FBgn0027538
Drosophila melanogaster	56336	FB:FBgn0027538

GlyTouCan

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Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements