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glutathione peroxidase 1
Summary
- Gene Symbol
-
- GPX1
- Aliases
-
- selenoprotein GPX1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Alternative splicing
- Cytoplasm
- Lipid metabolism
- Mitochondrion
- Peroxidase
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Selenium
- Selenocysteine
- Proteins
| UniProt | Protein Name |
|---|---|
| Q7L4Q3 |
|
| A0A2R8Y6B6 |
|
| P07203 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| response to folic acid | ||
| response to nicotine | ||
| response to vitamin E | ||
| arachidonic acid metabolic process | ||
| vasodilation |
GO Hierarchy
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
negative regulation of metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
negative regulation of biological process [inference]
negative regulation of metabolic process [inference]
negative regulation of signaling [inference]
negative regulation of cellular process [inference]
negative regulation of response to stimulus [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of programmed cell death [inference]
negative regulation of cellular process [inference]
regulation of molecular function [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| phospholipid-hydroperoxide glutathione peroxidase activity | ||
| glutathione peroxidase activity | ||
| protein binding | ||
| SH3 domain binding |
GO Hierarchy
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0014667 | disease of metabolism | |
| DOID:0050083 | Keshan disease | |
| DOID:0050328 | congenital hypothyroidism | |
| DOID:0050387 | nonpapillary renal cell carcinoma | |
| DOID:0050452 | mevalonic aciduria | |
| DOID:0050589 | inflammatory bowel disease | |
| DOID:0050635 | alternating hemiplegia of childhood | |
| DOID:0050657 | Bannayan-Riley-Ruvalcaba syndrome | |
| DOID:0050745 | diffuse large B-cell lymphoma | |
| DOID:0050782 | Zollinger-Ellison syndrome |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0003265 | Neonatal hyperbilirubinemia |
| HP:0004863 | Compensated hemolytic anemia |
| Disease ID | Disease Name |
|---|---|
| OMIM:614164 |
|
PubChem Disease
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP006150
- Gene Name
- glutathione peroxidase 1
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 181178 | WB:WBGene00007516 | ||
| 182513 | WB:WBGene00007517 | ||
| 352926 | ZFIN:ZDB-GENE-030410-1 | ||
| 447895 | ZFIN:ZDB-GENE-040912-60 | ||
| 115583664 | SPAAU40057 | ||
| 496242 | Xenbase:XB-GENE-922644 | ||
| 734385 | Xenbase:XB-GENE-17333381 | ||
| 548457 | Xenbase:XB-GENE-922630 | ||
| 100392863 | CALJA11684 | ||
| 105573690 | CERAT32352 |
