GlyCosmos Portal

Annotation

Keyword

Aspartyl protease
Autocatalytic cleavage
Cell membrane
Disulfide bond
Endoplasmic reticulum
Endosome
Glycoprotein
Golgi apparatus
Reference proteome
Signal
Transmembrane helix
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q6IE75	Beta-site amyloid precursor protein cleaving enzyme 2 Memapsin-1 Membrane-associated aspartic protease 1 Theta-secretase
A6IQF8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
signaling receptor ligand precursor processing	ISO
glucose homeostasis	ISO
membrane protein ectodomain proteolysis	IBA ISO ISS
amyloid-beta metabolic process	IBA
melanosome organization	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process

protein metabolic process [inference]

proteolysis [inference]

protein processing

signaling receptor ligand precursor processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing

cellular process [inference]

cell activation [inference]

glial cell activation [inference]

astrocyte activation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization [inference]

pigment granule organization [inference]

melanosome organization

multicellular organismal process [inference]

cell activation [inference]

glial cell activation [inference]

astrocyte activation

homeostatic process [inference]

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein metabolic process [inference]

regulation of glycoprotein biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein metabolic process [inference]

regulation of glycoprotein biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein metabolic process [inference]

regulation of glycoprotein biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
Golgi apparatus	ISO ISS
plasma membrane	IBA ISO ISS
endosome	IBA
trans-Golgi network	IBA
dense core granule	IDA	19117266

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

pigment granule membrane [inference]

melanosome membrane

bounding membrane of organelle [inference]

pigment granule membrane [inference]

melanosome membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

secretory vesicle [inference]

secretory granule [inference]

dense core granule

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

secretory vesicle [inference]

secretory granule [inference]

dense core granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

secretory vesicle [inference]

secretory granule [inference]

dense core granule

Displaying **all 2** entries
GO Term	Evidence Code	PMID
aspartic-type endopeptidase activity	ISO ISS
peptidase activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity [inference]

aspartic-type endopeptidase activity

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

aspartic-type endopeptidase activity

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

beta-secretase 2

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 5** entries
Gene Ontology
amyloid-beta metabolic process
aspartic-type endopeptidase activity
hydrolase activity
membrane protein ectodomain proteolysis
proteolysis

Displaying **all 5** entries
InterPro
Aspartic peptidase A1 family
Aspartic peptidase domain superfamily
Beta-secretase BACE2
Beta-secretase BACE
Peptidase family A1 domain

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
dense core granule	PMID:19117266

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:9255	frontotemporal dementia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 98 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	25825		HGNC:934	HUMAN58690
Mus musculus	56175	10090_1:004b48	MGI:1860440	MOUSE18582
Danio rerio	449818		ZFIN:ZDB-GENE-041010-68	DANRE08623
Bos taurus	534774			BOVIN15410
Pan troglodytes	747819			PANTR25710
Saccharomyces cerevisiae S288C	851950		SGD:S000002757
Monodelphis domestica	100016587			MONDO21518
Ornithorhynchus anatinus	100080196			ORNAN10120
Ornithorhynchus anatinus	100080224			ORNAN10120
Ornithorhynchus anatinus	100080247			ORNAN10120

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements