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beta-secretase 2

Summary

Gene Symbol

Bace2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

288227

PubChem

288227

Alliance of Genome Resources

RGD:1303241

Annotation

Keyword

Aspartyl protease
Autocatalytic cleavage
Cell membrane
Disulfide bond
Endoplasmic reticulum
Endosome
Glycoprotein
Golgi apparatus
Reference proteome
Signal
Transmembrane helix
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q6IE75	Beta-site amyloid precursor protein cleaving enzyme 2 Memapsin-1 Membrane-associated aspartic protease 1 Theta-secretase
A6IQF8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
proteolysis
membrane protein ectodomain proteolysis	ISS
membrane protein ectodomain proteolysis	ISO
membrane protein ectodomain proteolysis	IBA
protein processing	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing

cellular process [inference]

cell activation [inference]

glial cell activation [inference]

astrocyte activation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization [inference]

pigment granule organization [inference]

melanosome organization

multicellular organismal process [inference]

cell activation [inference]

glial cell activation [inference]

astrocyte activation

homeostatic process [inference]

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein metabolic process [inference]

regulation of glycoprotein biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein metabolic process [inference]

regulation of glycoprotein biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein metabolic process [inference]

regulation of glycoprotein biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of glycoprotein metabolic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of glycoprotein biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

regulation of amyloid precursor protein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of glycoprotein biosynthetic process [inference]

negative regulation of amyloid precursor protein biosynthetic process

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
endosome	IBA
endoplasmic reticulum	IEA
Golgi apparatus	ISS
Golgi apparatus	ISO
trans-Golgi network	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

pigment granule membrane [inference]

melanosome membrane

bounding membrane of organelle [inference]

pigment granule membrane [inference]

melanosome membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

secretory vesicle [inference]

secretory granule [inference]

dense core granule

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

secretory vesicle [inference]

secretory granule [inference]

dense core granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

secretory vesicle [inference]

secretory granule [inference]

dense core granule

Displaying **all 3** entries
GO Term	Evidence Code	PMID
aspartic-type endopeptidase activity	ISS
aspartic-type endopeptidase activity	ISO
peptidase activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity [inference]

aspartic-type endopeptidase activity

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

aspartic-type endopeptidase activity

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Beta-secretase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
amyloid-beta metabolic process
aspartic-type endopeptidase activity
hydrolase activity
membrane protein ectodomain proteolysis
proteolysis

Displaying **all 6** entries
InterPro
Aspartic peptidase A1 family
Aspartic peptidase domain superfamily
Aspartic peptidase, active site
Beta-secretase BACE
Memapsin-like
Peptidase family A1 domain

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
dense core granule	PMID:19117266

Ortholog

Displaying entries **1 - 10** of 67 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	25825	Xenbase:XB-GENE-1014090	HUMAN58690
Mus musculus	56175	Xenbase:XB-GENE-1014090	MOUSE18582
Xenopus tropicalis	288227	Xenbase:XB-GENE-1014090
Xenopus tropicalis	380307	Xenbase:XB-GENE-1014090
Xenopus tropicalis	398806	Xenbase:XB-GENE-1014090
Danio rerio	449818		DANRE08623
Bos taurus	534774		BOVIN15410
Pan troglodytes	747819		PANTR25710
Homo sapiens	850812	HGNC:934
Saccharomyces cerevisiae S288C	851950	SGD:S000002757

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OrthoDB (Group)

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Acknowledgements