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Guidelines

MIRAGE

WD repeat domain, phosphoinositide interacting 2

Summary

Gene Symbol

Wipi2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

288498

PubChem

288498

Alliance of Genome Resources

RGD:1359154

Annotation

Keyword

Autophagy
Lipid-binding
Membrane
Phosphoprotein
Reference proteome
Repeat
WD repeat

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q6AY57
A6K1P6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
autophagosome assembly	ISS
autophagosome assembly	ISO
autophagy of mitochondrion	IBA
pexophagy	IBA
biological_process	ND

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

C-terminal protein lipidation [inference]

protein lipidation involved in autophagosome assembly

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein lipidation [inference]

protein lipidation involved in autophagosome assembly

catabolic process [inference]

cellular catabolic process [inference]

autophagy [inference]

autophagy of mitochondrion

macroautophagy [inference]

autophagy of peroxisome [inference]

pexophagy

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy [inference]

autophagy of mitochondrion

macroautophagy [inference]

autophagy of peroxisome [inference]

pexophagy

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

C-terminal protein lipidation [inference]

protein lipidation involved in autophagosome assembly

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein lipidation [inference]

protein lipidation involved in autophagosome assembly

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

C-terminal protein lipidation [inference]

protein lipidation involved in autophagosome assembly

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein lipidation [inference]

protein lipidation involved in autophagosome assembly

macromolecule modification [inference]

protein modification process [inference]

protein lipidation [inference]

C-terminal protein lipidation [inference]

protein lipidation involved in autophagosome assembly

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein lipidation [inference]

protein lipidation involved in autophagosome assembly

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

C-terminal protein lipidation [inference]

protein lipidation involved in autophagosome assembly

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein lipidation [inference]

protein lipidation involved in autophagosome assembly

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy [inference]

autophagy of mitochondrion

macroautophagy [inference]

autophagy of peroxisome [inference]

pexophagy

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to phagophore assembly site

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

process utilizing autophagic mechanism [inference]

autophagy [inference]

autophagy of mitochondrion

macroautophagy [inference]

autophagy of peroxisome [inference]

pexophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization [inference]

autophagy of mitochondrion

vacuole organization [inference]

autophagosome organization [inference]

autophagosome assembly

organelle assembly [inference]

autophagosome assembly

organelle disassembly [inference]

autophagy of mitochondrion

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

autophagosome maturation

organelle disassembly [inference]

autophagy of mitochondrion

cellular component assembly [inference]

organelle assembly [inference]

autophagosome assembly

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

autophagosome maturation

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to phagophore assembly site

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to phagophore assembly site

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
phagophore assembly site	ISO
nucleoplasm	ISO
nucleoplasm	IEA
autophagosome	ISO
cytosol	ISS

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

phagophore assembly site membrane

extrinsic component of membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

autophagosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

autophagosome

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
phosphatidylinositol-5-phosphate binding	ISO
protein-macromolecule adaptor activity	IBA
phosphatidylinositol-3-phosphate binding	ISS
phosphatidylinositol-3-phosphate binding	ISO
phosphatidylinositol-3-phosphate binding	IBA

GO Hierarchy

molecular function

binding [inference]

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol bisphosphate binding [inference]

phosphatidylinositol-3,5-bisphosphate binding

ion binding [inference]

anion binding [inference]

phosphatidylinositol-3,5-bisphosphate binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Autophagy-related protein

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
nucleophagy
phosphatidylinositol-3,5-bisphosphate binding
phosphatidylinositol-3-phosphate binding
protein localization to phagophore assembly site

Displaying **all 4** entries
InterPro
PROPPIN
WD40 repeat
WD40-repeat-containing domain superfamily
WD40/YVTN repeat-like-containing domain superfamily

Ortholog

Displaying entries **1 - 10** of 78 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	26100	ZFIN:ZDB-GENE-040718-488	HUMAN87700
Saccharomyces cerevisiae S288C	52639	SGD:S000001917
Saccharomyces cerevisiae S288C	55062	SGD:S000006021
Mus musculus	74781		MOUSE46979
Danio rerio	179246	ZFIN:ZDB-GENE-040718-488
Danio rerio	288498	ZFIN:ZDB-GENE-040718-488
Danio rerio	437002		DANRE31442
Bos taurus	512685		BOVIN21014
Canis lupus familiaris	608721		CANLF16304
Macaca mulatta	702966		MACMU32534

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025