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EGF containing fibulin extracellular matrix protein 2

Summary

Gene Symbol

EFEMP2

Organism

Homo sapiens (human)

External Links

NCBI Gene

30008

PubChem

30008

Alliance of Genome Resources

HGNC:3219

Annotation

Keyword

3D-structure
Basement membrane
Calcium
Direct protein sequencing
Disease variant
Disulfide bond
EGF-like domain
Extracellular matrix
Glycoprotein
Reference proteome
Repeat
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O95967	Fibulin-4 Protein UPH1
Q9H3D5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
positive regulation of aortic smooth muscle cell differentiation	ISS
positive regulation of collagen fibril organization	ISS
vascular associated smooth muscle cell development	ISS
aorta development	ISS
regulation of collagen fibril organization	ISS

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell development [inference]

muscle cell development [inference]

vascular associated smooth muscle cell development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

extracellular matrix assembly [inference]

elastic fiber assembly

extracellular structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix assembly [inference]

elastic fiber assembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix assembly [inference]

elastic fiber assembly

supramolecular fiber organization [inference]

elastic fiber assembly

developmental process [inference]

anatomical structure morphogenesis [inference]

tissue morphogenesis [inference]

muscle tissue morphogenesis [inference]

aorta smooth muscle tissue morphogenesis

anatomical structure development [inference]

blood vessel development [inference]

artery development [inference]

aorta development

cell development [inference]

muscle cell development [inference]

vascular associated smooth muscle cell development

cellular developmental process [inference]

cell development [inference]

muscle cell development [inference]

vascular associated smooth muscle cell development

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of cell-matrix adhesion [inference]

positive regulation of smooth muscle cell-matrix adhesion

positive regulation of cellular component organization [inference]

positive regulation of supramolecular fiber organization [inference]

positive regulation of collagen fibril organization

positive regulation of extracellular matrix organization [inference]

positive regulation of collagen fibril organization

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation [inference]

negative regulation of vascular associated smooth muscle cell proliferation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

regulation of smooth muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

regulation of vascular associated smooth muscle cell differentiation [inference]

regulation of aortic smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-substrate adhesion [inference]

regulation of cell-matrix adhesion [inference]

positive regulation of cell-matrix adhesion [inference]

positive regulation of smooth muscle cell-matrix adhesion

regulation of smooth muscle cell-matrix adhesion [inference]

positive regulation of smooth muscle cell-matrix adhesion

positive regulation of cell-substrate adhesion [inference]

positive regulation of cell-matrix adhesion [inference]

positive regulation of smooth muscle cell-matrix adhesion

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of cell-matrix adhesion [inference]

positive regulation of smooth muscle cell-matrix adhesion

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation [inference]

negative regulation of vascular associated smooth muscle cell proliferation

regulation of smooth muscle cell proliferation [inference]

negative regulation of smooth muscle cell proliferation [inference]

negative regulation of vascular associated smooth muscle cell proliferation

regulation of vascular associated smooth muscle cell proliferation [inference]

negative regulation of vascular associated smooth muscle cell proliferation

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

regulation of smooth muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

regulation of vascular associated smooth muscle cell differentiation [inference]

regulation of aortic smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of cell-matrix adhesion [inference]

positive regulation of smooth muscle cell-matrix adhesion

positive regulation of cellular component organization [inference]

positive regulation of supramolecular fiber organization [inference]

positive regulation of collagen fibril organization

positive regulation of extracellular matrix organization [inference]

positive regulation of collagen fibril organization

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation [inference]

negative regulation of vascular associated smooth muscle cell proliferation

regulation of cellular component organization [inference]

positive regulation of cellular component organization [inference]

positive regulation of supramolecular fiber organization [inference]

positive regulation of collagen fibril organization

positive regulation of extracellular matrix organization [inference]

positive regulation of collagen fibril organization

regulation of supramolecular fiber organization [inference]

positive regulation of supramolecular fiber organization [inference]

positive regulation of collagen fibril organization

regulation of collagen fibril organization

positive regulation of collagen fibril organization

regulation of extracellular matrix organization [inference]

positive regulation of extracellular matrix organization [inference]

positive regulation of collagen fibril organization

regulation of collagen fibril organization

positive regulation of collagen fibril organization

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
extracellular matrix	IDA ISS	20389311 27339457
microfibril	ISS
extracellular vesicle	HDA	24769233
collagen-containing extracellular matrix	HDA	28327460
basement membrane	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

basement membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle

extracellular exosome

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	16189514 16478991 16713569 19349279 19570982 19855011 22919265 23088713 25416956 25910212 26871637 27339457 29892012 32296183 32814053
heparin binding	IDA	23782690
extracellular matrix structural constituent	RCA	28327460
calcium ion binding	IEA
protein homodimerization activity	IDA	23782690

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Kinase

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
ATP binding
kinase activity
nucleotide binding
phosphorylation

Displaying **all 2** entries
InterPro
Protein kinase domain
Protein kinase-like domain superfamily

Disease

Disease Ontology

Displaying entries **1 - 10** of 11 in total

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DO ID	Disease Name	Source
DOID:0050645	arterial tortuosity syndrome	Alliance of Genome Resources
DOID:0070133	autosomal recessive cutis laxa type IB	Alliance of Genome Resources
DOID:0080685	aortic dissection	Alliance of Genome Resources
DOID:1380	endometrial cancer	Alliance of Genome Resources
DOID:2394	ovarian cancer	Alliance of Genome Resources
DOID:2893	cervix carcinoma	Alliance of Genome Resources
DOID:3144	cutis laxa	Alliance of Genome Resources
DOID:3347	osteosarcoma	Alliance of Genome Resources
DOID:3376	bone osteosarcoma	Alliance of Genome Resources
DOID:3627	aortic aneurysm	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 70 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Pongo abelii	100452252	9601_0:002e18	PONAB03469
Ailuropoda melanoleuca	100464231		AILME15413
Sus scrofa	100526031		PIGXX16782
Nomascus leucogenys	100590798		NOMLE30268
Cavia porcellus	100733120		CAVPO15637
Cricetulus griseus	100736553		CRIGR19302
Otolemur garnettii	100960311		OTOGA04522
Pan paniscus	100989091	9597_0:00322a	PANPA07151
Papio anubis	101009369		PAPAN05510
Saimiri boliviensis boliviensis	101042833		SAIBB28970

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements