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complement factor H

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

3075

PubChem

3075

Alliance of Genome Resources

HGNC:4883

Annotation

Keyword

3D-structure
Age-related macular degeneration
Alternative splicing
Complement alternate pathway
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Hemolytic uremic syndrome
Host-virus interaction
Proteomics identification
Reference proteome
Repeat
Secreted
Signal
Sulfation
Sushi

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0D9SG88
P08603	H factor 1

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
proteolysis	IDA	28671664
complement activation	IDA	24835392
complement activation	IBA
complement activation, alternative pathway	IEA
regulation of complement activation	IDA	25284781

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

complement activation, alternative pathway

activation of immune response [inference]

complement activation

complement activation, alternative pathway

immune response [inference]

humoral immune response [inference]

complement activation

complement activation, alternative pathway

innate immune response [inference]

complement activation, alternative pathway

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

immune response [inference]

humoral immune response [inference]

complement activation

complement activation, alternative pathway

innate immune response [inference]

complement activation, alternative pathway

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, alternative pathway

regulation of immune effector process [inference]

regulation of complement activation

regulation of complement activation, alternative pathway

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of complement activation

regulation of complement activation, alternative pathway

regulation of innate immune response [inference]

regulation of complement activation, alternative pathway

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, alternative pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, alternative pathway

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, alternative pathway

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of innate immune response [inference]

regulation of complement activation, alternative pathway

regulation of response to external stimulus [inference]

regulation of innate immune response [inference]

regulation of complement activation, alternative pathway

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, alternative pathway

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of complement activation

regulation of complement activation, alternative pathway

regulation of innate immune response [inference]

regulation of complement activation, alternative pathway

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, alternative pathway

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of innate immune response [inference]

regulation of complement activation, alternative pathway

regulation of cellular process [inference]

regulation of cell killing [inference]

regulation of complement-dependent cytotoxicity

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	NAS	20378178 28671664
extracellular space	IBA
extracellular exosome	HDA	23533145
blood microparticle	HDA	22516433

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

peptidase complex [inference]

serine-type peptidase complex [inference]

serine-type endopeptidase complex

endopeptidase complex [inference]

serine-type endopeptidase complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

other organism part [inference]

symbiont cell surface

blood microparticle

Displaying **all 5** entries
GO Term	Evidence Code	PMID
complement component C3b binding	IBA
protein binding	IPI	16612335 17244159 17293598 17339482 17399790 18627465 18786923 19050261 19084272 19225461 19632990 19680263 19850925 20042240 21317894 21930971 21979047 22786770 23332154 24835392 26468283 26538390 28258151 28533443 28671664 29374201
heparin binding	IDA	22471560
identical protein binding	IPI	19505476 19850925 26468283
heparan sulfate proteoglycan binding	IDA	22471560

GO Hierarchy

molecular function

binding [inference]

protein binding

opsonin binding [inference]

complement component C3b binding

complement binding [inference]

complement component C3b binding

identical protein binding

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

sulfur compound binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Complement factor H

Functional Category

G: Carbohydrate transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
complement activation
complement component C3b binding

Displaying **all 2** entries
InterPro
Sushi/SCR/CCP domain
Sushi/SCR/CCP superfamily

Disease

Disease Ontology

Displaying entries **1 - 10** of 17 in total

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DO ID	Disease Name	Source
DOID:0060746	basal laminar drusen	Alliance of Genome Resources
DOID:0080162	lupus nephritis	Alliance of Genome Resources
DOID:0080301	atypical hemolytic-uremic syndrome	Alliance of Genome Resources
DOID:0080600	COVID-19	Alliance of Genome Resources
DOID:0110017	age related macular degeneration 4	Alliance of Genome Resources
DOID:11335	sarcoidosis	Alliance of Genome Resources
DOID:12030	panuveitis	Alliance of Genome Resources
DOID:12554	hemolytic-uremic syndrome	Alliance of Genome Resources
DOID:12574	posterior uveitis	Alliance of Genome Resources
DOID:1287	cardiovascular system disease	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	2165	ZFIN:ZDB-GENE-041114-123
Xenopus tropicalis	3075	Xenbase:XB-GENE-981265
Danio rerio	3078	ZFIN:ZDB-GENE-050208-661
Danio rerio	10877	ZFIN:ZDB-GENE-041114-123
Rattus norvegicus	10878	RGD:1564614
Mus musculus	12628	Xenbase:XB-GENE-981265	MOUSE30483
Danio rerio	50702	ZFIN:ZDB-GENE-050208-661
Danio rerio	81494	ZFIN:ZDB-GENE-041114-123
Rattus norvegicus	155012		RATNO06818
Rattus norvegicus	185381	RGD:620428

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements