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Submissions

tsukushi, small leucine rich proteoglycan

Summary

Gene Symbol

Tsku

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

308843

PubChem

308843

Alliance of Genome Resources

RGD:1359311

Annotation

Keyword

Developmental protein
Glycoprotein
Leucine-rich repeat
Neurogenesis
Reference proteome
Repeat
Secreted
Signal

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q6QMY6	Early insulin-induced hepatic gene protein Leucine-rich repeat-containing protein 54
A6I6D6
A0A8I6G739

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 52 in total

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GO Term	Evidence Code	PMID
growth plate cartilage chondrocyte development	ISS
cholesterol metabolic process	ISS
cholesterol metabolic process	ISO
cholesterol metabolic process	IEA
regulation of gene expression	ISS

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

cellular developmental process [inference]

cell development [inference]

chondrocyte development [inference]

chondrocyte development involved in endochondral bone morphogenesis [inference]

growth plate cartilage chondrocyte development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis [inference]

central nervous system neuron axonogenesis [inference]

central nervous system projection neuron axonogenesis [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

inner ear receptor cell stereocilium organization

multicellular organismal process [inference]

organ growth [inference]

bone growth

multicellular organismal-level homeostasis [inference]

energy homeostasis

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis [inference]

central nervous system neuron axonogenesis [inference]

central nervous system projection neuron axonogenesis [inference]

ciliary body morphogenesis

anatomical structure development [inference]

cell development [inference]

chondrocyte development [inference]

chondrocyte development involved in endochondral bone morphogenesis [inference]

growth plate cartilage chondrocyte development

animal organ development [inference]

sensory organ development [inference]

eye development [inference]

camera-type eye development

cellular developmental process [inference]

cell development [inference]

chondrocyte development [inference]

chondrocyte development involved in endochondral bone morphogenesis [inference]

growth plate cartilage chondrocyte development

growth [inference]

developmental growth [inference]

organ growth [inference]

bone growth

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

energy homeostasis

chemical homeostasis [inference]

lipid homeostasis [inference]

sterol homeostasis [inference]

cholesterol homeostasis

response to stimulus [inference]

response to stress [inference]

response to wounding [inference]

wound healing

localization [inference]

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

lipid transport [inference]

sterol transport [inference]

cholesterol transport [inference]

cholesterol efflux

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport [inference]

cholesterol efflux

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of transforming growth factor beta production [inference]

regulation of transforming growth factor beta1 production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of transforming growth factor beta production [inference]

regulation of transforming growth factor beta1 production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of transforming growth factor beta production [inference]

regulation of transforming growth factor beta1 production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

positive regulation of biological process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of hair cycle

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of cell differentiation [inference]

negative regulation of myofibroblast differentiation

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of myofibroblast differentiation

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of myofibroblast differentiation

regulation of myofibroblast differentiation [inference]

negative regulation of myofibroblast differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of myofibroblast differentiation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of transforming growth factor beta production [inference]

regulation of transforming growth factor beta1 production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of myofibroblast differentiation

regulation of myofibroblast differentiation [inference]

negative regulation of myofibroblast differentiation

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of cell differentiation [inference]

negative regulation of myofibroblast differentiation

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

negative regulation of neuron projection development

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of transforming growth factor beta production [inference]

regulation of transforming growth factor beta1 production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of hair cycle [inference]

positive regulation of hair cycle

positive regulation of multicellular organismal process [inference]

positive regulation of hair cycle

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular space	ISS
extracellular space	ISO
extracellular space	IBA
extracellular space	IEA
extracellular matrix	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

external encapsulating structure [inference]

extracellular matrix

Displaying **all 3** entries
GO Term	Evidence Code	PMID
transforming growth factor beta binding	ISS
transforming growth factor beta binding	ISO
transforming growth factor beta binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

growth factor binding [inference]

transforming growth factor beta binding

cytokine binding [inference]

transforming growth factor beta binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Leucine-rich repeat

Functional Category

M: Cell wall/membrane/envelope biogenesis
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
Leucine-rich repeat domain superfamily
Leucine-rich repeat, typical subtype
Leucine-rich repeat

Ortholog

Displaying entries **1 - 10** of **103** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	3483	FB:FBgn0268063
Drosophila melanogaster	4064	FB:FBgn0268063
Drosophila melanogaster	7098	FB:FBgn0268063
Drosophila melanogaster	10234	FB:FBgn0268063
Drosophila melanogaster	14723	FB:FBgn0268063
Drosophila melanogaster	17079	FB:FBgn0268063
Homo sapiens	25987	Xenbase:XB-GENE-493206	HUMAN08344
Homo sapiens	37549	HGNC:28850
Drosophila melanogaster	79438	FB:FBgn0268063
Drosophila melanogaster	116135	FB:FBgn0268063

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Acknowledgements