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spectrin repeat containing, nuclear envelope 2

Summary

Gene Symbol

Syne2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

319565

PubChem

319565

Alliance of Genome Resources

MGI:2449316

Annotation

Keyword

Actin-binding
Alternative splicing
Cell membrane
Coiled coil
Cytoskeleton
Disulfide bond
Mitochondrion
Nucleus
Phosphoprotein
Reference proteome
Repeat
Sarcoplasmic reticulum
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q6ZWQ0	KASH domain-containing protein 2 Nuclear envelope spectrin repeat protein 2 Nucleus and actin connecting element protein Synaptic nuclear envelope protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
nuclear envelope organization
nuclear migration	ISO
establishment or maintenance of cell polarity
fibroblast migration
nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration	IMP	19874786

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

establishment or maintenance of cell polarity

actin filament-based process [inference]

actin filament-based movement [inference]

nuclear migration along microfilament

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

fibroblast migration

cellular localization [inference]

intracellular transport [inference]

nuclear migration

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

nuclear migration along microfilament

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

actin filament-based transport [inference]

nuclear migration along microfilament

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus

microtubule organizing center localization [inference]

centrosome localization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

nuclear envelope organization

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

nuclear migration

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

nuclear migration along microfilament

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

actin filament-based transport [inference]

nuclear migration along microfilament

microtubule-based transport [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

establishment of localization in cell [inference]

intracellular transport [inference]

nuclear migration

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

nuclear migration along microfilament

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

actin filament-based transport [inference]

nuclear migration along microfilament

establishment of organelle localization [inference]

nuclear migration

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

nuclear migration along microfilament

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

organelle localization [inference]

nucleus localization [inference]

nuclear migration

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

nuclear migration along microfilament

establishment of organelle localization [inference]

nuclear migration

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

nuclear migration along microfilament

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

cellular localization [inference]

intracellular transport [inference]

nuclear migration

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

nuclear migration along microfilament

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

organelle transport along microtubule [inference]

nuclear migration along microtubule [inference]

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

actin filament-based transport [inference]

nuclear migration along microfilament

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus

microtubule organizing center localization [inference]

centrosome localization

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cellular process [inference]

regulation of cellular component biogenesis [inference]

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of cilium assembly

regulation of organelle assembly [inference]

regulation of cilium assembly

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of cilium assembly

regulation of plasma membrane bounded cell projection organization [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of cilium assembly

regulation of organelle organization [inference]

regulation of organelle assembly [inference]

regulation of cilium assembly

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

Displaying entries **1 - 5** of 29 in total

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GO Term	Evidence Code	PMID
fibrillar center	IEA
nucleus	ISO
nuclear envelope	ISO
nuclear envelope	TAS
nuclear envelope	IDA	15671068 20457914 26506308

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

nuclear membrane protein complex [inference]

nuclear membrane microtubule tethering complex [inference]

meiotic nuclear membrane microtubule tethering complex

nuclear protein-containing complex [inference]

nuclear membrane protein complex [inference]

nuclear membrane microtubule tethering complex [inference]

meiotic nuclear membrane microtubule tethering complex

cellular anatomical entity [inference]

membrane [inference]

outer membrane [inference]

organelle outer membrane [inference]

nuclear outer membrane

organelle membrane [inference]

endoplasmic reticulum membrane [inference]

sarcoplasmic reticulum membrane

nuclear membrane

nuclear outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

nuclear outer membrane

sarcoplasmic reticulum membrane

plasma membrane region [inference]

cell projection membrane [inference]

Z disc

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

leading edge membrane [inference]

lamellipodium membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

nuclear lumen

envelope [inference]

organelle envelope [inference]

nuclear envelope

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

sarcoplasmic reticulum

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton

contractile fiber [inference]

myofibril

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

sarcoplasmic reticulum

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton

contractile fiber [inference]

myofibril

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

contractile fiber [inference]

myofibril

Displaying **all 3** entries
GO Term	Evidence Code	PMID
actin binding	IDA	20724637
protein binding	IPI	24880667 26688217
cytoskeleton-nuclear membrane anchor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

protein-membrane adaptor activity [inference]

cytoskeleton-nuclear membrane anchor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

alpha-actinin A

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
InterPro
Calponin homology domain

Ortholog

Displaying entries **1 - 10** of 41 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	23224	ZFIN:ZDB-GENE-071218-5	HUMAN19749
Drosophila melanogaster	23345	FB:FBgn0261836
Drosophila melanogaster	64009	FB:FBgn0261836
Danio rerio	319565	ZFIN:ZDB-GENE-071218-5
Rattus norvegicus	366669		RATNO36619
Canis lupus familiaris	490729		CANLF17988
Bos taurus	540504		BOVIN01540
Macaca mulatta	706759		MACMU41795
Danio rerio	3771968	ZFIN:ZDB-GENE-041001-109
Ornithorhynchus anatinus	100081014		ORNAN05762