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aldehyde dehydrogenase 6 family member A1

Summary

Gene Symbol

ALDH6A1

Organism

Bos taurus (cattle)

External Links

NCBI Gene: 327692
KEGG Gene ID: bta:327692
PubChem: 327692

Annotation

Keyword

Acetylation
Direct protein sequencing
Mitochondrion
NAD
Oxidoreductase
Phosphoprotein
Reference proteome
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
Q07536	Aldehyde dehydrogenase family 6 member A1 Malonate-semialdehyde dehydrogenase [acylating]

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
valine catabolic process	IEA	30032202
thymine catabolic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

thymine metabolic process [inference]

thymine catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

cellular nitrogen compound catabolic process [inference]

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

thymine metabolic process [inference]

thymine catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

branched-chain amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

thymine metabolic process [inference]

thymine catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

thymine metabolic process [inference]

thymine catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

cellular nitrogen compound catabolic process [inference]

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

heterocycle catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

organic cyclic compound catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

branched-chain amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

thymine metabolic process [inference]

thymine catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

thymine metabolic process [inference]

thymine catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

cellular nitrogen compound catabolic process [inference]

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

thymine metabolic process [inference]

thymine catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

cellular nitrogen compound catabolic process [inference]

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

heterocycle catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

thymine metabolic process [inference]

thymine catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

heterocycle catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

thymine metabolic process [inference]

thymine catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

thymine metabolic process [inference]

thymine catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

branched-chain amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

branched-chain amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

thymine metabolic process [inference]

thymine catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

branched-chain amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

thymine metabolic process [inference]

thymine catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

thymine metabolic process [inference]

thymine catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

organic cyclic compound catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

branched-chain amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

thymine metabolic process [inference]

thymine catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

thymine metabolic process [inference]

thymine catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

organic cyclic compound catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

branched-chain amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid metabolic process [inference]

valine metabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

thymine metabolic process [inference]

thymine catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

thymine metabolic process [inference]

thymine catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

cellular nitrogen compound catabolic process [inference]

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

thymine metabolic process [inference]

thymine catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

branched-chain amino acid catabolic process [inference]

valine catabolic process

alpha-amino acid catabolic process [inference]

valine catabolic process

cellular nitrogen compound catabolic process [inference]

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

heterocycle catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

thymine metabolic process [inference]

thymine catabolic process

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

heterocycle catabolic process [inference]

nucleobase catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

thymine metabolic process [inference]

thymine catabolic process

pyrimidine-containing compound catabolic process [inference]

pyrimidine nucleobase catabolic process [inference]

thymine catabolic process

Displaying 1 entry
GO Term	Evidence Code	PMID
mitochondrion	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 2** entries
GO Term	Evidence Code	PMID
malonate-semialdehyde dehydrogenase (acetylating) activity	IEA	30032202
methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [inference]

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00140

Name

malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase [EC:1.2.1.18 1.2.1.27]

References

Rhea

H₂O + CoA + NAD⁺ + 2-methyl-3-oxopropanoate

H⁺ + hydrogencarbonate + propanoyl-CoA + NADH

Enzyme

1.2.1.27

PMID

H₂O + 3-oxopropanoate + CoA + NAD⁺

H⁺ + hydrogencarbonate + acetyl-CoA + NADH

Enzyme

1.2.1.27

PMID

16332250

Ortholog

Displaying entries **11 - 20** of 95 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Gadus morhua	115544109		GADMO48577
Poecilia reticulata	103457893		POERE18946
Xiphophorus maculatus	102226812		XIPMA14231
Oryzias latipes	101158320		ORYLA11336
Oryzias latipes	101161931		ORYLA10472
Oreochromis niloticus	100706096		ORENI19469
Oreochromis niloticus	100708820		ORENI30100
Haplochromis burtoni	102294806		HAPBU04645
Astatotilapia calliptera	113006910		ASTCA10139
Sparus aurata	115573587		SPAAU62844

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Acknowledgements

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024