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MIRAGE
5-hydroxytryptamine receptor 3A

Summary
Gene Symbol
  • HTR3A
Organism
Homo sapiens (human)
NCBI Gene
3359
PubChem
3359
Alliance of Genome Resources
JoGo
HTR3A
TogoVar
HTR3A
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Cell membrane
  • Disulfide bond
  • Glycoprotein
  • Ligand-gated ion channel
  • Postsynaptic cell membrane
  • Proteomics identification
  • Receptor
  • Reference proteome
  • Signal
  • Transmembrane helix
Proteins
Displaying all 2 entries
UniProt Protein Name
B4E398
  • 5-hydroxytryptamine receptor 3
  • Serotonin receptor 3A
  • Serotonin-gated ion channel receptor
P46098
  • 5-hydroxytryptamine receptor 3
  • Serotonin receptor 3A
  • Serotonin-gated ion channel receptor
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 1 - 5 of 9 in total
GO Term Evidence Code PMID
serotonin receptor signaling pathway
chemical synaptic transmission
monoatomic ion transmembrane transport
ion transmembrane transport
regulation of membrane potential
GO Hierarchy
Displaying entries 1 - 5 of 8 in total
GO Term Evidence Code PMID
excitatory extracellular ligand-gated monoatomic ion channel activity
protein binding
serotonin-gated monoatomic cation channel activity
serotonin-gated monoatomic cation channel activity
identical protein binding
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
acetylcholine receptor subunit alpha
Functional Category
  • E: Amino acid transport and metabolism
  • T: Signal transduction mechanisms
  • X: Mobilome: prophages, transposons
Displaying all 4 entries
Gene Ontology
extracellular ligand-gated monoatomic ion channel activity
ligand-gated monoatomic ion channel activity
monoatomic ion channel activity
monoatomic ion transport
Displaying all 9 entries
InterPro
5-hydroxytryptamine 3 receptor, A subunit
5-hydroxytryptamine 3 receptor
Neuronal acetylcholine receptor
Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Neurotransmitter-gated ion-channel ligand-binding domain
Neurotransmitter-gated ion-channel transmembrane domain superfamily
Neurotransmitter-gated ion-channel transmembrane domain
Neurotransmitter-gated ion-channel, conserved site
Neurotransmitter-gated ion-channel
Disease
Disease Ontology
Displaying all 5 entries
DO ID Disease Name Source
DOID:0050741 alcohol dependence
DOID:0050742 nicotine dependence
DOID:9778 irritable bowel syndrome
DOID:9975 cocaine dependence
DOID:9976 heroin dependence
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026