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Guidelines

MIRAGE

immunoglobulin mu DNA binding protein 2

Summary

Gene Symbol

IGHMBP2

Organism

Homo sapiens (human)

External Links

NCBI Gene

3508

PubChem

3508

Alliance of Genome Resources

HGNC:5542

Annotation

Keyword

3D-structure
Acetylation
Activator
Cell projection
Charcot-Marie-Tooth disease
Cytoplasm
DNA-binding
Direct protein sequencing
Disease variant
Helicase
Neurodegeneration
Nucleus
Reference proteome
Ribonucleoprotein
Transcription regulation
Zinc-finger
tRNA-binding

Proteins

Displaying 1 entry
UniProt	Protein Name
P38935	ATP-dependent helicase IGHMBP2 Glial factor 1 Immunoglobulin mu-binding protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
RNA secondary structure unwinding
DNA duplex unwinding

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA secondary structure unwinding

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA secondary structure unwinding

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA secondary structure unwinding

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA secondary structure unwinding

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA secondary structure unwinding

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA secondary structure unwinding

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA secondary structure unwinding

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA secondary structure unwinding

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA secondary structure unwinding

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA secondary structure unwinding

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

DNA conformation change [inference]

DNA geometric change [inference]

DNA duplex unwinding

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
nucleus	IDA	19299493
nucleus	IBA
nucleoplasm	IDA
cytoplasm	IDA	19299493
cytoplasm	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

ribonucleoprotein complex

cellular anatomical entity [inference]

site of polarized growth [inference]

growth cone

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 28 in total

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GO Term	Evidence Code	PMID
tRNA binding	IDA	19299493
DNA binding	IDA	19158098
DNA helicase activity	TAS	8349627
DNA clamp loader activity
single-stranded DNA binding	IDA	30218034

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

catalytic activity, acting on a protein [inference]

ATP-dependent histone chaperone activity [inference]

catalytic activity, acting on a nucleic acid [inference]

helicase activity [inference]

DNA helicase activity

four-way junction helicase activity

single-stranded DNA helicase activity [inference]

single-stranded 3'-5' DNA helicase activity

double-stranded DNA helicase activity

3'-5' DNA helicase activity [inference]

single-stranded 3'-5' DNA helicase activity

RNA helicase activity [inference]

5'-3' RNA helicase activity

catalytic activity, acting on DNA [inference]

ATP-dependent activity, acting on DNA

DNA helicase activity

four-way junction helicase activity

single-stranded DNA helicase activity [inference]

single-stranded 3'-5' DNA helicase activity

double-stranded DNA helicase activity

3'-5' DNA helicase activity [inference]

single-stranded 3'-5' DNA helicase activity

DNA clamp loader activity

DNA translocase activity [inference]

chromatin extrusion motor activity

ATP-dependent chromatin remodeler activity [inference]

ATP-dependent histone chaperone activity [inference]

cohesin loader activity

catalytic activity, acting on RNA [inference]

RNA helicase activity [inference]

5'-3' RNA helicase activity

binding [inference]

protein binding

transcription factor binding

general transcription initiation factor binding

identical protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

protein-containing complex binding [inference]

ribonucleoprotein complex binding [inference]

ribosome binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

single-stranded DNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular carrier activity [inference]

protein carrier chaperone [inference]

histone chaperone activity [inference]

H3-H4 histone complex chaperone activity [inference]

ATP-dependent H3-H4 histone complex chaperone activity

ATP-dependent histone chaperone activity [inference]

ATP-dependent activity [inference]

helicase activity [inference]

DNA helicase activity

four-way junction helicase activity

single-stranded DNA helicase activity [inference]

single-stranded 3'-5' DNA helicase activity

double-stranded DNA helicase activity

3'-5' DNA helicase activity [inference]

single-stranded 3'-5' DNA helicase activity

RNA helicase activity [inference]

5'-3' RNA helicase activity

ATP-dependent activity, acting on DNA

DNA helicase activity

four-way junction helicase activity

single-stranded DNA helicase activity [inference]

single-stranded 3'-5' DNA helicase activity

double-stranded DNA helicase activity

3'-5' DNA helicase activity [inference]

single-stranded 3'-5' DNA helicase activity

DNA clamp loader activity

DNA translocase activity [inference]

chromatin extrusion motor activity

ATP-dependent chromatin remodeler activity [inference]

ATP-dependent histone chaperone activity [inference]

ATP-dependent activity, acting on RNA

RNA helicase activity [inference]

5'-3' RNA helicase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

nonsense transcript regulator

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
ATP binding
hydrolase activity
metal ion binding
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
nucleotide binding
regulation of gene expression
zinc ion binding

Displaying **all 7** entries
InterPro
DNA2/NAM7 helicase, helicase domain
DNA2/NAM7 helicase-like, C-terminal
DNA2/NAM7-like helicase
P-loop containing nucleoside triphosphate hydrolase
RNA helicase UPF1, 1B domain
RNA helicase UPF1, Cys/His rich zinc-binding domain
Upf1-like, C-terminal helicase domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110171	Charcot-Marie-Tooth disease axonal type 2S	Alliance of Genome Resources
DOID:0111064	autosomal recessive distal hereditary motor neuronopathy 1	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 66 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	3508	Xenbase:XB-GENE-6258282
Mus musculus	20589		MOUSE25459
Rattus norvegicus	29532		RATNO19087
Pan troglodytes	451384		PANTR03640
Canis lupus familiaris	483686		CANLF05952
Danio rerio	556484		DANRE14239
Bos taurus	618606		BOVIN23621
Macaca mulatta	721554		MACMU09086
Ciona intestinalis	751571		CIOIN04088
Equus caballus	100060088		HORSE05784

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025