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interleukin 12B
Summary
- Gene Symbol
-
- IL12B
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Cytokine
- Direct protein sequencing
- Disulfide bond
- Glycoprotein
- Immunoglobulin domain
- Reference proteome
- Secreted
- Signal
- Proteins
| UniProt | Protein Name |
|---|---|
| P29460 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| regulation of cytokine production | ||
| positive regulation of T cell mediated cytotoxicity | ||
| positive regulation of defense response to virus by host | ||
| positive regulation of defense response to virus by host | ||
| natural killer cell activation involved in immune response |
GO Hierarchy
biological process
immune system process [inference]
cellular process [inference]
multicellular organismal process [inference]
developmental process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
positive regulation of immune system process [inference]
positive regulation of leukocyte activation [inference]
positive regulation of immune effector process [inference]
positive regulation of immune response [inference]
regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of lymphocyte proliferation [inference]
regulation of T cell activation [inference]
regulation of T cell differentiation [inference]
regulation of alpha-beta T cell activation [inference]
positive regulation of lymphocyte activation [inference]
regulation of immune effector process [inference]
positive regulation of immune effector process [inference]
regulation of leukocyte mediated immunity [inference]
regulation of immune response [inference]
regulation of adaptive immune response [inference]
regulation of immune response to tumor cell [inference]
regulation of innate immune response [inference]
positive regulation of immune response [inference]
regulation of hemopoiesis [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of signaling [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of leukocyte activation [inference]
positive regulation of immune effector process [inference]
positive regulation of immune response [inference]
positive regulation of metabolic process [inference]
positive regulation of cellular process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cell differentiation [inference]
positive regulation of cell adhesion
positive regulation of cell activation [inference]
positive regulation of response to stimulus [inference]
positive regulation of response to biotic stimulus [inference]
positive regulation of defense response [inference]
positive regulation of response to external stimulus [inference]
positive regulation of immune response [inference]
positive regulation of developmental process [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of response to biotic stimulus [inference]
regulation of signal transduction [inference]
regulation of response to external stimulus [inference]
positive regulation of response to stimulus [inference]
positive regulation of response to biotic stimulus [inference]
positive regulation of defense response [inference]
positive regulation of response to external stimulus [inference]
positive regulation of immune response [inference]
negative regulation of response to stimulus [inference]
regulation of immune response [inference]
regulation of adaptive immune response [inference]
regulation of immune response to tumor cell [inference]
regulation of innate immune response [inference]
positive regulation of immune response [inference]
regulation of response to stress [inference]
regulation of developmental process [inference]
regulation of cell differentiation [inference]
positive regulation of cell differentiation [inference]
regulation of cell development [inference]
positive regulation of cell development [inference]
regulation of hemopoiesis [inference]
positive regulation of developmental process [inference]
regulation of multicellular organismal development [inference]
regulation of hemopoiesis [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cell adhesion [inference]
regulation of cellular metabolic process [inference]
regulation of cell killing [inference]
regulation of cell population proliferation [inference]
regulation of cell differentiation [inference]
positive regulation of cell differentiation [inference]
regulation of cell development [inference]
positive regulation of cell development [inference]
regulation of hemopoiesis [inference]
positive regulation of cellular process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cell differentiation [inference]
positive regulation of cell adhesion
positive regulation of cell activation [inference]
negative regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of lymphocyte proliferation [inference]
regulation of T cell activation [inference]
regulation of T cell differentiation [inference]
regulation of alpha-beta T cell activation [inference]
positive regulation of lymphocyte activation [inference]
positive regulation of cell activation [inference]
regulation of multicellular organismal process [inference]
regulation of cytokine production
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of lymphocyte proliferation [inference]
regulation of T cell activation [inference]
regulation of T cell differentiation [inference]
regulation of alpha-beta T cell activation [inference]
positive regulation of lymphocyte activation [inference]
positive regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
regulation of multicellular organismal development [inference]
regulation of hemopoiesis [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region | ||
| extracellular space | ||
| extracellular space | ||
| endoplasmic reticulum lumen | ||
| cytosol |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| cytokine receptor activity | ||
| cytokine activity | ||
| cytokine activity | ||
| interleukin-12 receptor binding | ||
| interleukin-12 receptor binding |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Interleukin-12 subunit beta
- Functional Category
-
- E: Amino acid transport and metabolism
- I: Lipid transport and metabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| cytokine activity |
| cytokine-mediated signaling pathway |
| InterPro |
|---|
| Fibronectin type III superfamily |
| Immunoglobulin-like domain |
| Immunoglobulin-like fold |
| Interleukin-12 beta, central domain |
| Interleukin-12 beta |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060859 | salmonellosis | |
| DOID:0111950 | immunodeficiency 29 | |
| DOID:2841 | asthma | |
| DOID:3083 | chronic obstructive pulmonary disease |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 3593 | ZFIN:ZDB-GENE-050525-3 | ||
| 16160 | ZFIN:ZDB-GENE-030131-7937 | MOUSE04187 | |
| 64546 | RATNO03180 | ||
| 281857 | BOVIN33843 | ||
| 397076 | PIGXX10887 | ||
| 403976 | CANLF14861 | ||
| 443472 | SHEEP16991 | ||
| 471723 | PANTR36717 | ||
| 768273 | FELCA01047 | ||
| 100034222 | HORSE07774 |
