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Interleukin-12 subunit beta

Summary

UniProt ID

P29460

Gene Symbol

IL12B
NKSF2

Organism

Homo sapiens (human)

External Links

GlyConnect

GlyGen

P29460

PubChem

P29460

Annotation

Keyword

3D-structure
Cytokine
Direct protein sequencing
Disulfide bond
Glycoprotein
Immunoglobulin domain
Reference proteome
Secreted
Signal

Gene Ontology (GO)

Displaying entries **1 - 10** of 53 in total

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GO Term
positive regulation of T cell mediated cytotoxicity
natural killer cell activation involved in immune response
positive regulation of T-helper 1 type immune response
cell migration
cytokine-mediated signaling pathway
sexual reproduction
natural killer cell activation
cellular response to lipopolysaccharide
negative regulation of inflammatory response to antigenic stimulus
positive regulation of defense response to virus by host

Displaying **all 9** entries
GO Term
interleukin-12 complex
cytosol
endoplasmic reticulum lumen
external side of plasma membrane
interleukin-23 complex
extracellular region
extracellular space
receptor complex
late endosome lumen

Displaying **all 8** entries
GO Term
cytokine receptor activity
cytokine binding
protein-containing complex binding
identical protein binding
protein heterodimerization activity
cytokine activity
interleukin-12 receptor binding
interleukin-12 alpha subunit binding

Annotation information from UniProt.

Sequence

MCHQQLVISWFSLVFLASPLVAIWELKKDVYVVELDWYPDAPGEMVVLTCDTPEEDGITWTLDQSSEVLGSGKTLTIQVKEFGDAGQYTCHKGGEVLSHSLLLLHKKEDGIWSTDILKDQKEPKNKTFLRCEAKNYSGRFTCWWLTTISTDLTFSVKSSRGSSDPQGVTCGAATLSAERVRGDNKEYEYSVECQEDSACPAAEESLPIEVMVDAVHKLKYENYTSSFFIRDIIKPDPPKNLQLKPLKNSRQVEVSWEYPDTWSTPHSYFSLTFCVQVQGKSKREKKDRVFTDKTSATVICRKNASISVRAQDRYYSSSWSEWASVPCS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
135	N-linked (GlcNAc...) asparagine			UniProt GlyGen
222	N-linked (GlcNAc...) asparagine	10899108		UniProt GlyGen
319	C-linked (Man) tryptophan	10207176	G70323CJ	UniProt GlyGen
			G70323CJ	GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Interleukin-10 signaling	Homo sapiens
Interleukin-12 signaling	Homo sapiens
Interleukin-23 signaling	Homo sapiens
Interleukin-4 and Interleukin-13 signaling	Homo sapiens