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Interleukin-12 subunit beta

Summary

UniProt ID

P29460

Gene Symbol

IL12B
NKSF2

Organism

Homo sapiens (human)

External Links

GlyConnect

GlyGen

P29460

PubChem

P29460

Annotation

Keyword

3D-structure
Cytokine
Direct protein sequencing
Disulfide bond
Glycoprotein
Immunoglobulin domain
Reference proteome
Secreted
Signal

Gene Ontology (GO)

Displaying entries **1 - 10** of 53 in total

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GO Term
positive regulation of T cell mediated cytotoxicity
natural killer cell activation involved in immune response
positive regulation of T-helper 1 type immune response
cell migration
cytokine-mediated signaling pathway
sexual reproduction
natural killer cell activation
positive regulation of natural killer cell activation
T-helper 1 type immune response
T cell proliferation

Displaying **all 9** entries
GO Term
extracellular region
extracellular space
receptor complex
late endosome lumen
interleukin-12 complex
cytosol
endoplasmic reticulum lumen
external side of plasma membrane
interleukin-23 complex

Displaying **all 8** entries
GO Term
cytokine receptor activity
cytokine binding
protein-containing complex binding
identical protein binding
protein heterodimerization activity
cytokine activity
interleukin-12 receptor binding
interleukin-12 alpha subunit binding

Annotation information from UniProt.

Sequence

MCHQQLVISWFSLVFLASPLVAIWELKKDVYVVELDWYPDAPGEMVVLTCDTPEEDGITWTLDQSSEVLGSGKTLTIQVKEFGDAGQYTCHKGGEVLSHSLLLLHKKEDGIWSTDILKDQKEPKNKTFLRCEAKNYSGRFTCWWLTTISTDLTFSVKSSRGSSDPQGVTCGAATLSAERVRGDNKEYEYSVECQEDSACPAAEESLPIEVMVDAVHKLKYENYTSSFFIRDIIKPDPPKNLQLKPLKNSRQVEVSWEYPDTWSTPHSYFSLTFCVQVQGKSKREKKDRVFTDKTSATVICRKNASISVRAQDRYYSSSWSEWASVPCS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
135	N-linked (GlcNAc...) asparagine			UniProt GlyGen
222	N-linked (GlcNAc...) asparagine	10899108		UniProt GlyGen
319	C-linked (Man) tryptophan	10207176	G70323CJ	UniProt GlyGen
			G70323CJ	GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Interleukin-10 signaling	Homo sapiens
Interleukin-12 signaling	Homo sapiens
Interleukin-23 signaling	Homo sapiens
Interleukin-4 and Interleukin-13 signaling	Homo sapiens