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Interleukin-23 signaling

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9020933

PubChem

R-HSA-9020933

Description

Interleukin-23 (IL23) is a heterodimer of Interleukin-12 subunit beta (IL12B, IL-12p40), which is shared with IL12, and Interleukin-23 subunit alpha IL23A (IL-23p19) subunit. The functional receptor for IL23 consists of Interleukin-12 receptor subunit beta-1 (IL12RB1), which is shared with the IL12 receptor, and Interleukin-23 receptor (IL23R). IL23R is mainly expresed on activated memory T cells, Natural Killer cells, monocytes/macrophage and at low levels on dendritic cells (DCs). IL23 is mainly secreted by activated macrophages and DCs in peripheral tissues such as skin, intestinal mucosa and lung. IL23 is proinlflammatory and implicated in several autoimmune inflammatory disorders such as colitis, gastritis, psoriasis and arthritis. It is similar to IL-12 both in structure and its ability to memory T cells to increase interferon-γ (IFN-γ) production and proliferation, the ability of IL-23 to induce IL-17. IL23 activates the Janus kinases JAK2 and TYK2, resulting in phosphorylation of the receptor complex, which forms the docking sites for Signal transducer and activator of transcription 3 (STAT3) and STAT4 to bind and become phosphorylated.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 7** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P07237	Protein disulfide-isomerase	ERBA2L P4HB PDI PDIA1 PO4DB	view
P29460	Interleukin-12 subunit beta	IL12B NKSF2	view
P29597	Non-receptor tyrosine-protein kinase TYK2	TYK2	view
P40763	Signal transducer and activator of transcription 3	APRF STAT3	view
P42701	Interleukin-12 receptor subunit beta-1	IL12R IL12RB IL12RB1	view
Q14765	Signal transducer and activator of transcription 4	STAT4	view
Q5VWK5	Interleukin-23 receptor	IL23R	view

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