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integrin subunit alpha 1

Summary

Gene Symbol

ITGA1

Organism

Homo sapiens (human)

External Links

NCBI Gene

3672

PubChem

3672

Alliance of Genome Resources

HGNC:6134

Annotation

Keyword

3D-structure
Calcium
Cell adhesion
Disulfide bond
Glycoprotein
Integrin
Magnesium
Metal-binding
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P56199	CD49 antigen-like family member A Laminin and collagen receptor VLA-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 16 in total

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GO Term	Evidence Code	PMID
negative regulation of cell population proliferation	IMP	15592458
neutrophil chemotaxis	IEA
positive regulation of phosphoprotein phosphatase activity
cell adhesion mediated by integrin	IBA
negative regulation of epidermal growth factor receptor signaling pathway	ISS

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

cellular extravasation

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

cellular process [inference]

cell adhesion [inference]

cell-substrate adhesion [inference]

cell-matrix adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

cellular extravasation

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasodilation

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphate metabolic process [inference]

regulation of dephosphorylation [inference]

regulation of phosphatase activity [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of protein dephosphorylation [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of protein dephosphorylation [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of protein dephosphorylation [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of protein dephosphorylation [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphate metabolic process [inference]

regulation of dephosphorylation [inference]

regulation of phosphatase activity [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of protein dephosphorylation [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

positive regulation of neuron apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasodilation

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of hydrolase activity [inference]

regulation of phosphatase activity [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of hydrolase activity [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
acrosomal vesicle	IEA
plasma membrane	TAS
focal adhesion	IDA	11518510
focal adhesion	HDA	21423176
integrin complex	TAS	8428973

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

integrin alpha1-beta1 complex

protein complex involved in cell adhesion [inference]

integrin complex

integrin alpha1-beta1 complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

integrin alpha1-beta1 complex

cellular anatomical entity [inference]

cell surface

membrane

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

basal part of cell

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
integrin binding	IBA
protein binding	IPI	16754661 18587047
collagen binding	TAS	8428973
phosphatase activator activity	IDA	15592458
protein phosphatase binding	IPI	15592458

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

enzyme binding [inference]

phosphatase binding [inference]

protein phosphatase binding

cell adhesion molecule binding [inference]

integrin binding

cell adhesion mediator activity [inference]

cell-matrix adhesion mediator activity [inference]

collagen binding involved in cell-matrix adhesion

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

integrin binding

collagen binding

collagen binding involved in cell-matrix adhesion

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

phosphatase activator activity

phosphatase regulator activity [inference]

phosphatase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

phosphatase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

pelota

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
RNA surveillance
metal ion binding
nonfunctional rRNA decay
nuclear-transcribed mRNA catabolic process, no-go decay
nuclear-transcribed mRNA catabolic process, non-stop decay
ribosome disassembly

Displaying **all 7** entries
InterPro
Pelota/DOM34, N-terminal domain
Ribosomal protein eL30-like superfamily
Translation release factor pelota
eRF1 domain 1/Pelota-like
eRF1 domain 2
eRF1 domain 3
eRF1, domain 2 superfamily

Ortholog

Displaying entries **11 - 20** of 94 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	22801	FB:FBgn0286785
Rattus norvegicus	25118	Xenbase:XB-GENE-6258629	RATNO24432
Xenopus tropicalis	36692	Xenbase:XB-GENE-6258629
Xenopus tropicalis	37732	Xenbase:XB-GENE-6258629
Drosophila melanogaster	104099	FB:FBgn0286785
Mus musculus	109700	Xenbase:XB-GENE-6258629	MOUSE11671
Pan troglodytes	461880		PANTR35587
Canis lupus familiaris	489210		CANLF14960
Bos taurus	535951		BOVIN15953
Danio rerio	570868		DANRE00322

GlyTouCan

GlyComb

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LM-GlycoRepo

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Acknowledgements