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Janus kinase 3
Summary
- Gene Symbol
-
- JAK3
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Adaptive immunity
- Alternative splicing
- Cytoplasm
- Disease variant
- Innate immunity
- Membrane
- Phosphoprotein
- Reference proteome
- Repeat
- SCID
- SH2 domain
- Tyrosine-protein kinase
- Proteins
| UniProt | Protein Name |
|---|---|
| P52333 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| adaptive immune response | ||
| negative regulation of dendritic cell cytokine production | ||
| enzyme-linked receptor protein signaling pathway | ||
| receptor signaling pathway via JAK-STAT | ||
| receptor signaling pathway via JAK-STAT |
GO Hierarchy
biological process
metabolic process [inference]
cellular process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
negative regulation of immune system process [inference]
regulation of leukocyte activation [inference]
negative regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of T cell activation [inference]
regulation of T cell differentiation [inference]
regulation of alpha-beta T cell activation [inference]
negative regulation of alpha-beta T cell activation [inference]
regulation of alpha-beta T cell differentiation [inference]
regulation of CD4-positive, alpha-beta T cell activation [inference]
negative regulation of T cell activation
negative regulation of lymphocyte activation [inference]
regulation of immune effector process [inference]
regulation of immune response [inference]
regulation of hemopoiesis [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of biosynthetic process [inference]
regulation of cellular biosynthetic process [inference]
negative regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
negative regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
negative regulation of biological process [inference]
negative regulation of immune system process [inference]
negative regulation of metabolic process [inference]
negative regulation of cellular process [inference]
negative regulation of cell adhesion [inference]
negative regulation of cellular metabolic process [inference]
negative regulation of cell differentiation [inference]
negative regulation of cell activation [inference]
negative regulation of response to stimulus [inference]
negative regulation of developmental process [inference]
negative regulation of multicellular organismal process [inference]
regulation of response to stimulus [inference]
negative regulation of response to stimulus [inference]
regulation of immune response [inference]
regulation of developmental process [inference]
regulation of cell differentiation [inference]
negative regulation of cell differentiation [inference]
regulation of cell development [inference]
negative regulation of cell development [inference]
regulation of hemopoiesis [inference]
negative regulation of developmental process [inference]
regulation of multicellular organismal development [inference]
regulation of hemopoiesis [inference]
regulation of cellular process [inference]
signal transduction [inference]
regulation of cell adhesion [inference]
negative regulation of cell adhesion [inference]
regulation of cell-cell adhesion [inference]
negative regulation of cell-cell adhesion [inference]
regulation of leukocyte cell-cell adhesion [inference]
regulation of cellular metabolic process [inference]
negative regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of programmed cell death [inference]
regulation of cell differentiation [inference]
negative regulation of cell differentiation [inference]
regulation of cell development [inference]
negative regulation of cell development [inference]
regulation of hemopoiesis [inference]
negative regulation of cellular process [inference]
negative regulation of cell adhesion [inference]
negative regulation of cellular metabolic process [inference]
negative regulation of cell differentiation [inference]
negative regulation of cell activation [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
negative regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of T cell activation [inference]
regulation of T cell differentiation [inference]
regulation of alpha-beta T cell activation [inference]
negative regulation of alpha-beta T cell activation [inference]
regulation of alpha-beta T cell differentiation [inference]
regulation of CD4-positive, alpha-beta T cell activation [inference]
negative regulation of T cell activation
negative regulation of lymphocyte activation [inference]
negative regulation of cell activation [inference]
regulation of multicellular organismal process [inference]
regulation of cytokine production [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
negative regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of T cell activation [inference]
regulation of T cell differentiation [inference]
regulation of alpha-beta T cell activation [inference]
negative regulation of alpha-beta T cell activation [inference]
regulation of alpha-beta T cell differentiation [inference]
regulation of CD4-positive, alpha-beta T cell activation [inference]
negative regulation of T cell activation
negative regulation of lymphocyte activation [inference]
negative regulation of cell activation [inference]
negative regulation of multicellular organismal process [inference]
regulation of multicellular organismal development [inference]
regulation of hemopoiesis [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| endosome | ||
| cytosol | ||
| cytosol | ||
| cytoskeleton | ||
| plasma membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein tyrosine kinase activity | ||
| protein tyrosine kinase activity | ||
| protein tyrosine kinase activity | ||
| protein tyrosine kinase activity | ||
| non-membrane spanning protein tyrosine kinase activity |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- protein kinase
- Functional Category
-
- M: Cell wall/membrane/envelope biogenesis
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| InterPro |
|---|
| Protein kinase domain |
| Protein kinase-like domain superfamily |
| Serine-threonine/tyrosine-protein kinase, catalytic domain |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050458 | juvenile myelomonocytic leukemia | |
| DOID:0050523 | adult T-cell leukemia/lymphoma | |
| DOID:0081042 | T-cell prolymphocytic leukemia | |
| DOID:0081312 | T-cell non-Hodgkin lymphoma | |
| DOID:5603 | T-cell acute lymphoblastic leukemia | |
| DOID:627 | severe combined immunodeficiency | |
| DOID:8761 | acute megakaryocytic leukemia |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 3716 | FB:FBgn0004864 | ||
| 3718 | Xenbase:XB-GENE-5904698 | ||
| 7297 | FB:FBgn0004864 | ||
| 16453 | MOUSE60442 | ||
| 25326 | RATNO10804 | ||
| 538276 | BOVIN32219 | ||
| 610004 | CANLF07660 | ||
| 748892 | PANTR17598 | ||
| 778659 | CIOIN00444 | ||
| 100085612 | ORNAN28091 |
