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keratin 2

Summary

Gene Symbol

KRT2

Organism

Homo sapiens (human)

External Links

NCBI Gene

3849

PubChem

3849

Alliance of Genome Resources

HGNC:6439

Annotation

Keyword

Coiled coil
Cytoplasm
Disease variant
Ichthyosis
Intermediate filament
Keratin
Methylation
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P35908	Cytokeratin-2e Epithelial keratin-2e Keratin-2 epidermis Keratin-2e Type-II keratin Kb2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
positive regulation of epidermis development	ISS
keratinocyte proliferation	IDA	12598329
keratinocyte development	IEA
epidermis development	TAS	7524919
peptide cross-linking	IDA	7543090

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

macromolecule modification [inference]

protein modification process [inference]

peptide cross-linking

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptide cross-linking

cellular process [inference]

cell activation [inference]

keratinocyte activation

cell population proliferation [inference]

epithelial cell proliferation [inference]

keratinocyte proliferation

intermediate filament-based process [inference]

intermediate filament cytoskeleton organization [inference]

intermediate filament organization

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

keratinocyte development

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

epithelial cell migration [inference]

keratinocyte migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

intermediate filament cytoskeleton organization [inference]

intermediate filament organization

supramolecular fiber organization [inference]

intermediate filament organization

multicellular organismal process [inference]

cell activation [inference]

keratinocyte activation

keratinization

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

epidermis development

cell development [inference]

epithelial cell development [inference]

keratinocyte development

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

keratinocyte development

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of developmental process [inference]

positive regulation of epidermis development

regulation of developmental process [inference]

regulation of epidermis development [inference]

positive regulation of epidermis development

positive regulation of developmental process [inference]

positive regulation of epidermis development

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
membrane	HDA	19946888
cornified envelope	IDA	7543090
keratin filament	IBA
intermediate filament	TAS	1380918
extracellular space	HDA	23580065

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane [inference]

cornified envelope

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

intermediate filament

keratin filament

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	25416956 25910212 29892012 31515488 32296183
structural constituent of skin epidermis	IBA IDA	7543090
structural constituent of cytoskeleton	TAS	1380918
cytoskeletal protein binding	IEA

GO Hierarchy

molecular function

structural molecule activity [inference]

binding [inference]

protein binding

cytoskeletal protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Keratin, type II

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 3** entries
Gene Ontology
intermediate filament organization
keratinization
structural constituent of skin epidermis

Displaying **all 4** entries
InterPro
Intermediate filament protein, conserved site
Intermediate filament, rod domain
Keratin type II head
Keratin, type II

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060877	bullous congenital ichthyosiform erythroderma	Alliance of Genome Resources
DOID:1697	ichthyosis	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 45 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Pteropus vampyrus	105302682		PTEVA04622
Macaca nemestrina	105474306		MACNE24308
Mandrillus leucophaeus	105555263		MANLE15582
Cercocebus atys	105580300		CERAT25034
Aotus nancymaae	105715838		AOTNA25209
Propithecus coquereli	105815553		PROCO09335
Microcebus murinus	105870426		MICMU13031
Dipodomys ordii	105997908		DIPOR20786
Rhinopithecus bieti	108521555		RHIBE20651
Gorilla gorilla gorilla	109025465	9595_0:003963

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements