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Laminin A

Summary

Gene Symbol

LanA

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

38723

PubChem

38723

Alliance of Genome Resources

FB:FBgn0002526

Annotation

Keyword

Basement membrane
Cell adhesion
Cell projection
Coiled coil
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Laminin EGF-like domain
Reference proteome
Repeat
Signal
Synapse

Proteins

Displaying 1 entry
UniProt	Protein Name
Q00174	Laminin A chain

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
dorsal trunk growth, open tracheal system	IMP	9409675
regulation of cell migration	IEA
regulation of cell adhesion	IEA
cell adhesion mediated by integrin	IDA	7972082
heart development	IMP	10075841

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

encapsulation of foreign target [inference]

melanotic encapsulation of foreign target

immune response [inference]

innate immune response [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

metabolic process [inference]

secondary metabolic process [inference]

melanin metabolic process [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

pigment metabolic process [inference]

melanin metabolic process [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

melanin metabolic process [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

organic substance metabolic process [inference]

organic cyclic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

melanin metabolic process [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

organic hydroxy compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

melanin metabolic process [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

cellular process [inference]

cell adhesion

cell-substrate adhesion [inference]

substrate adhesion-dependent cell spreading

cell adhesion mediated by integrin

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

melanin metabolic process [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

extracellular structure organization [inference]

extracellular matrix organization [inference]

basement membrane organization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

basement membrane organization

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis

anatomical structure development [inference]

tissue development

mesoderm development

animal organ development [inference]

heart development

growth [inference]

developmental growth [inference]

developmental growth involved in morphogenesis [inference]

dorsal trunk growth, open tracheal system

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

immune response [inference]

innate immune response [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

melanization defense response [inference]

melanotic encapsulation of foreign target

biological regulation [inference]

regulation of biological process [inference]

regulation of growth [inference]

negative regulation of growth [inference]

negative regulation of developmental growth [inference]

negative regulation of synaptic assembly at neuromuscular junction

regulation of developmental growth [inference]

regulation of synaptic assembly at neuromuscular junction [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of developmental growth [inference]

negative regulation of synaptic assembly at neuromuscular junction

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration

negative regulation of biological process [inference]

negative regulation of growth [inference]

negative regulation of developmental growth [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of cell junction assembly [inference]

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of synapse organization [inference]

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of neuromuscular junction development [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of nervous system development [inference]

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

regulation of developmental process [inference]

regulation of developmental growth [inference]

regulation of synaptic assembly at neuromuscular junction [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of developmental growth [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of nervous system development [inference]

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

regulation of multicellular organismal development [inference]

regulation of embryonic development

regulation of nervous system development [inference]

negative regulation of nervous system development [inference]

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

regulation of cellular process [inference]

regulation of cell adhesion

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of synaptic assembly at neuromuscular junction [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of cell junction assembly [inference]

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of cell junction assembly [inference]

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of synapse organization [inference]

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of neuromuscular junction development [inference]

negative regulation of synaptic assembly at neuromuscular junction

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of synaptic assembly at neuromuscular junction [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

regulation of neuromuscular junction development [inference]

regulation of synaptic assembly at neuromuscular junction [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of neuromuscular junction development [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of synapse organization [inference]

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of neuromuscular junction development [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of cellular component organization [inference]

negative regulation of cell junction assembly [inference]

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of synapse organization [inference]

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of neuromuscular junction development [inference]

negative regulation of synaptic assembly at neuromuscular junction

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of synaptic assembly at neuromuscular junction [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

negative regulation of cell junction assembly [inference]

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

regulation of cell motility [inference]

regulation of cell migration

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

regulation of multicellular organismal development [inference]

regulation of embryonic development

regulation of nervous system development [inference]

negative regulation of nervous system development [inference]

negative regulation of synapse assembly [inference]

negative regulation of synaptic assembly at neuromuscular junction

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
collagen-containing extracellular matrix	HDA	26896675
basement membrane	IBA IDA	1425586 18331716 27404358 30260959 7760738
extracellular region
presynaptic periactive zone	IDA	23054837
axon

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane [inference]

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic periactive zone

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

basement membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

Displaying **all 2** entries
GO Term	Evidence Code	PMID
signaling receptor binding	IEA
extracellular matrix structural constituent	IBA

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

protein binding [inference]

signaling receptor binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

laminin

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
P: Inorganic ion transport and metabolism

Displaying **all 2** entries
Gene Ontology
animal organ morphogenesis
tissue development

Displaying **all 2** entries
InterPro
Concanavalin A-like lectin/glucanase domain superfamily
Laminin G domain

Alliance of Genome Resources

Expression

Displaying **all 4** entries
Location	References
membrane	FB:FBrf0231198
presynaptic periactive zone	PMID:23054837
collagen-containing extracellular matrix	PMID:26896675
basement membrane	PMID:1425586 PMID:18331716 PMID:27404358 PMID:30260959 PMID:7760738

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0060738	junctional epidermolysis bullosa non-Herlitz type	Alliance of Genome Resources
DOID:2590	familial nephrotic syndrome	Alliance of Genome Resources
DOID:2975	cystic kidney disease	Alliance of Genome Resources
DOID:3209	junctional epidermolysis bullosa	Alliance of Genome Resources
DOID:5409	lung small cell carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 45 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Homo sapiens	3909		HGNC:6483
Homo sapiens	3911		HGNC:6485
Mus musculus	16774		MGI:99909
Mus musculus	16776		MGI:105382
Rattus norvegicus	140433		RGD:621023
Caenorhabditis elegans	177956		WB:WBGene00001328
Danio rerio	321243		ZFIN:ZDB-GENE-030131-9823
Drosophila pseudoobscura	4814167	7237_0:000b35
Drosophila ananassae	6493776	7217_1:00180e
Drosophila yakuba	6533187	7245_1:0023ae

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements