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marker of proliferation Ki-67

Summary

Gene Symbol

MKI67

Organism

Homo sapiens (human)

External Links

NCBI Gene

4288

PubChem

4288

Alliance of Genome Resources

HGNC:7107

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Cell cycle
Chromosome
DNA-binding
Isopeptide bond
Nucleus
Phosphoprotein
Reference proteome
Repeat
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P46013	Antigen identified by monoclonal antibody Ki-67

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
chromosome segregation	IDA	27362226 32879492 39153474
regulation of mitotic nuclear division	IDA	27362226
regulation of mitotic nuclear division	IBA
cell population proliferation	ISS
regulation of chromosome segregation

GO Hierarchy

biological process

cellular process [inference]

cell population proliferation

cell cycle process [inference]

chromosome segregation

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of nuclear division [inference]

regulation of mitotic nuclear division

regulation of chromatin organization

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

regulation of mitotic nuclear division

regulation of cell cycle process [inference]

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GO Term	Evidence Code	PMID
condensed chromosome	IDA	27362226 28935370 32879492 35513709 39153474
nucleus	IDA	22378020
nucleus	IBA
nucleoplasm	IDA
chromosome	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

condensed chromosome

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

chromosome

condensed chromosome

nucleolus

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GO Term	Evidence Code	PMID
DNA binding	IEA
RNA binding	IDA	28935370 39153474
RNA binding	HDA	22658674
protein binding	IPI	10878014 11342549 16244663 17577209 26949251
ATP binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

molecular condensate scaffold activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Antigen KI-67

Functional Category

I: Lipid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
regulation of chromosome segregation
regulation of mitotic nuclear division

Displaying **all 2** entries
InterPro
Forkhead-associated (FHA) domain
SMAD/FHA domain superfamily

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0081267	graft-versus-host disease	Alliance of Genome Resources
DOID:1612	breast cancer	Alliance of Genome Resources
DOID:1793	pancreatic cancer	Alliance of Genome Resources
DOID:526	human immunodeficiency virus infectious disease	Alliance of Genome Resources
DOID:687	hepatoblastoma	Alliance of Genome Resources
DOID:8778	Crohn's disease	Alliance of Genome Resources
DOID:9256	colorectal cancer	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	4288	Xenbase:XB-GENE-6457930
Mus musculus	17345	Xenbase:XB-GENE-6457930	MOUSE56157
Rattus norvegicus	291234		RATNO16345
Pan troglodytes	450866		PANTR01802
Bos taurus	513220		BOVIN21758
Macaca mulatta	697883		MACMU45795
Callithrix jacchus	100411224		CALJA08083
Pongo abelii	100433559		PONAB02084
Nomascus leucogenys	100586199		NOMLE26855
Cricetulus griseus	100756884		CRIGR24527

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements