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matrix metallopeptidase 9

Summary

Gene Symbol

MMP9

Organism

Homo sapiens (human)

External Links

NCBI Gene

4318

PubChem

4318

Alliance of Genome Resources

HGNC:7176

Annotation

Keyword

3D-structure
Calcium
Collagen degradation
Direct protein sequencing
Disulfide bond
Extracellular matrix
Glycoprotein
Metal-binding
Metalloprotease
Reference proteome
Repeat
Signal
Zinc
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
P14780	92 kDa gelatinase 92 kDa type IV collagenase Gelatinase B

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **26 - 30** of 30 in total

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GO Term	Evidence Code	PMID
positive regulation of vascular associated smooth muscle cell proliferation	IMP	18667463
negative regulation of epithelial cell differentiation involved in kidney development	ISS
negative regulation of intrinsic apoptotic signaling pathway	IMP	22984561
negative regulation of cation channel activity	IDA	24164424
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

catabolic process [inference]

collagen catabolic process

collagen metabolic process [inference]

collagen catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ephrin receptor signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation

endodermal cell differentiation

cell motility [inference]

cell migration

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-A

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component disassembly [inference]

extracellular matrix disassembly

extracellular structure organization [inference]

extracellular matrix organization

extracellular matrix disassembly

external encapsulating structure organization [inference]

extracellular matrix organization

extracellular matrix disassembly

reproductive process [inference]

embryo implantation

developmental process [inference]

anatomical structure development [inference]

system development [inference]

skeletal system development

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation

endodermal cell differentiation

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

response to UV [inference]

cellular response to UV [inference]

cellular response to UV-A

response to UV-A [inference]

cellular response to UV-A

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-A

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-A

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-A

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to organonitrogen compound [inference]

response to peptide [inference]

response to amyloid-beta

response to lipid [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to amyloid-beta

response to oxygen-containing compound [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

response to peptide [inference]

response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-A

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of cation channel activity

regulation of cation channel activity [inference]

negative regulation of cation channel activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of cation channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of cation channel activity

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of cation channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of cation channel activity

regulation of monoatomic cation transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of cation channel activity

regulation of cation channel activity [inference]

negative regulation of cation channel activity

regulation of monoatomic ion transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of cation channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of cation channel activity

regulation of monoatomic cation transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of cation channel activity

regulation of cation channel activity [inference]

negative regulation of cation channel activity

negative regulation of monoatomic ion transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of cation channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of cation channel activity

negative regulation of transport [inference]

negative regulation of transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of cation channel activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of cation channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of cation channel activity

negative regulation of monoatomic ion transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of cation channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of cation channel activity

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of keratinocyte migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of keratinocyte migration

regulation of keratinocyte migration [inference]

positive regulation of keratinocyte migration

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of keratinocyte migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of keratinocyte migration

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of keratinocyte migration

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of smooth muscle cell proliferation [inference]

positive regulation of vascular associated smooth muscle cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of release of cytochrome c from mitochondria

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of keratinocyte migration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of cation channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of cation channel activity

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation involved in kidney development

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of transport [inference]

negative regulation of transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of cation channel activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of cation channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of cation channel activity

negative regulation of monoatomic ion transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of cation channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of cation channel activity

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation involved in kidney development

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of response to external stimulus [inference]

regulation of inflammatory response [inference]

regulation of neuroinflammatory response

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of inflammatory response [inference]

regulation of neuroinflammatory response

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation involved in kidney development

regulation of epithelial cell differentiation involved in kidney development [inference]

negative regulation of epithelial cell differentiation involved in kidney development

negative regulation of cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation involved in kidney development

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation involved in kidney development

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation involved in kidney development

regulation of epithelial cell differentiation involved in kidney development [inference]

negative regulation of epithelial cell differentiation involved in kidney development

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ephrin receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of cation channel activity

regulation of cation channel activity [inference]

negative regulation of cation channel activity

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of cation channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of cation channel activity

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of cation channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of cation channel activity

regulation of monoatomic cation transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of cation channel activity

regulation of cation channel activity [inference]

negative regulation of cation channel activity

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of smooth muscle cell proliferation [inference]

positive regulation of vascular associated smooth muscle cell proliferation

regulation of smooth muscle cell proliferation [inference]

positive regulation of smooth muscle cell proliferation [inference]

positive regulation of vascular associated smooth muscle cell proliferation

regulation of vascular associated smooth muscle cell proliferation [inference]

positive regulation of vascular associated smooth muscle cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation involved in kidney development

regulation of epithelial cell differentiation involved in kidney development [inference]

negative regulation of epithelial cell differentiation involved in kidney development

negative regulation of cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation involved in kidney development

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of smooth muscle cell proliferation [inference]

positive regulation of vascular associated smooth muscle cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of ERBB signaling pathway [inference]

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of release of cytochrome c from mitochondria

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of keratinocyte migration

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of cation channel activity

negative regulation of cation transmembrane transport [inference]

negative regulation of cation channel activity

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation involved in kidney development

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of release of cytochrome c from mitochondria

regulation of mitochondrion organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of release of cytochrome c from mitochondria

regulation of release of cytochrome c from mitochondria [inference]

positive regulation of release of cytochrome c from mitochondria

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrion organization [inference]

positive regulation of release of cytochrome c from mitochondria

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of keratinocyte migration

regulation of keratinocyte migration [inference]

positive regulation of keratinocyte migration

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of keratinocyte migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of keratinocyte migration

regulation of multicellular organismal process [inference]

regulation of epithelial cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of keratinocyte migration

regulation of keratinocyte migration [inference]

positive regulation of keratinocyte migration

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation involved in kidney development

regulation of epithelial cell differentiation involved in kidney development [inference]

negative regulation of epithelial cell differentiation involved in kidney development

regulation of molecular function [inference]

regulation of transporter activity [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of cation channel activity

regulation of cation channel activity [inference]

negative regulation of cation channel activity

negative regulation of transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of cation channel activity

negative regulation of molecular function [inference]

negative regulation of transporter activity [inference]

negative regulation of ion transmembrane transporter activity [inference]

negative regulation of cation channel activity

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

positive regulation of molecular function [inference]

positive regulation of binding [inference]

positive regulation of protein binding [inference]

positive regulation of receptor binding

positive regulation of DNA binding

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of cysteine-type endopeptidase activity [inference]

regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

negative regulation of cysteine-type endopeptidase activity [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [inference]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

regulation of binding [inference]

regulation of protein binding [inference]

positive regulation of protein binding [inference]

positive regulation of receptor binding

regulation of receptor binding [inference]

positive regulation of receptor binding

positive regulation of binding [inference]

positive regulation of protein binding [inference]

positive regulation of receptor binding

positive regulation of DNA binding

regulation of DNA binding [inference]

positive regulation of DNA binding

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular region	HDA	27068509
extracellular space	IDA	24236012 2551898 25645918
extracellular space	IBA
collagen-containing extracellular matrix	HDA	28344315

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
endopeptidase activity	EXP	12062105 9256427
endopeptidase activity	IDA	19022250
metalloendopeptidase activity	TAS
metalloendopeptidase activity	IDA	16192646 24164424 2551898 9789069
metalloendopeptidase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

binding [inference]

protein binding

identical protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

protein-containing complex binding [inference]

collagen binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

metallopeptidase

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
collagen catabolic process
extracellular matrix organization
hydrolase activity
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis
zinc ion binding

Displaying **all 8** entries
InterPro
Hemopexin-like repeats
Metallopeptidase, catalytic domain superfamily
PGBD-like superfamily
Peptidase M10, metallopeptidase
Peptidase M10A, catalytic domain
Peptidase M10A
Peptidase, metallopeptidase
Peptidoglycan binding-like

Disease

Disease Ontology

Displaying entries **1 - 10** of 30 in total

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DO ID	Disease Name	Source
DOID:0050848	obstructive sleep apnea	Alliance of Genome Resources
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources
DOID:0060903	thrombosis	Alliance of Genome Resources
DOID:10123	pigmentation disease	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:10941	intracranial aneurysm	Alliance of Genome Resources
DOID:12894	Sjogren's syndrome	Alliance of Genome Resources
DOID:13375	temporal arteritis	Alliance of Genome Resources
DOID:13550	angle-closure glaucoma	Alliance of Genome Resources
DOID:13714	anodontia	Alliance of Genome Resources

Ortholog

Displaying entries **91 - 94** of 94 in total

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Species	Gene ID	Orthologous MAtrix
Scophthalmus maximus	118316335	SCOMX02337
Balaenoptera musculus	118881213	BALMU20236
Panthera leo	122215468	PANLE01340
Ursus americanus	123797065	URSAM25430

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements