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aralar1

Summary

Gene Symbol

aralar1

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

43616

PubChem

43616

Alliance of Genome Resources

FB:FBgn0028646

Annotation

Keyword

Alternative splicing
Calcium
Metal-binding
Mitochondrion inner membrane
Proteomics identification
Reference proteome
Repeat
Transmembrane helix
Transport

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q9VA73
A0A0B4KHW3
A0A0B4K6V1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 9** of 9 in total

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GO Term	Evidence Code	PMID
transmembrane transport	IEA
gamma-aminobutyric acid transport	IGI	32200800
aspartate transmembrane transport	IBA
mitochondrial calcium ion transmembrane transport	IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

cellular process [inference]

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

mitochondrial transmembrane transport [inference]

malate-aspartate shuttle

response to stimulus [inference]

response to stress [inference]

response to wounding [inference]

wound healing

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport

mitochondrial transport [inference]

mitochondrial calcium ion transmembrane transport

mitochondrial transmembrane transport [inference]

malate-aspartate shuttle

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

mitochondrial transmembrane transport [inference]

malate-aspartate shuttle

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport

L-glutamate import [inference]

L-glutamate transmembrane transport

amino acid transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

gamma-aminobutyric acid transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport

L-glutamate import [inference]

L-glutamate transmembrane transport

amino acid transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

gamma-aminobutyric acid transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

nitrogen compound transport [inference]

amino acid transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

gamma-aminobutyric acid transport

amide transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

Displaying **all 2** entries
GO Term	Evidence Code	PMID
mitochondrial inner membrane	IC	33497735
mitochondrion	HDA	19317464

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
gamma-aminobutyric acid:proton symporter activity	IGI	32200800
L-glutamate transmembrane transporter activity	IBA
identical protein binding	ISS
L-aspartate transmembrane transporter activity	IBA
aspartate:glutamate, proton antiporter activity	IDA	33497735

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

dicarboxylic acid transmembrane transporter activity [inference]

monocarboxylic acid transmembrane transporter activity [inference]

gamma-aminobutyric acid transmembrane transporter activity [inference]

gamma-aminobutyric acid:proton symporter activity

secondary active monocarboxylate transmembrane transporter activity [inference]

gamma-aminobutyric acid:proton symporter activity

amino acid transmembrane transporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:proton symporter activity [inference]

gamma-aminobutyric acid:proton symporter activity

acidic amino acid transmembrane transporter activity [inference]

L-amino acid transmembrane transporter activity [inference]

gamma-aminobutyric acid transmembrane transporter activity [inference]

gamma-aminobutyric acid:proton symporter activity

amino acid:monoatomic cation antiporter activity [inference]

aspartate:glutamate, proton antiporter activity

C4-dicarboxylate transmembrane transporter activity [inference]

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

dicarboxylic acid transmembrane transporter activity [inference]

monocarboxylic acid transmembrane transporter activity [inference]

gamma-aminobutyric acid transmembrane transporter activity [inference]

gamma-aminobutyric acid:proton symporter activity

secondary active monocarboxylate transmembrane transporter activity [inference]

gamma-aminobutyric acid:proton symporter activity

amino acid transmembrane transporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:proton symporter activity [inference]

gamma-aminobutyric acid:proton symporter activity

acidic amino acid transmembrane transporter activity [inference]

L-amino acid transmembrane transporter activity [inference]

gamma-aminobutyric acid transmembrane transporter activity [inference]

gamma-aminobutyric acid:proton symporter activity

amino acid:monoatomic cation antiporter activity [inference]

aspartate:glutamate, proton antiporter activity

C4-dicarboxylate transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

aspartate:glutamate, proton antiporter activity

solute:proton symporter activity [inference]

amino acid:proton symporter activity [inference]

gamma-aminobutyric acid:proton symporter activity

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:proton symporter activity [inference]

gamma-aminobutyric acid:proton symporter activity

solute:proton symporter activity [inference]

amino acid:proton symporter activity [inference]

gamma-aminobutyric acid:proton symporter activity

amino acid:monoatomic cation antiporter activity [inference]

aspartate:glutamate, proton antiporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:proton symporter activity [inference]

gamma-aminobutyric acid:proton symporter activity

solute:proton symporter activity [inference]

amino acid:proton symporter activity [inference]

gamma-aminobutyric acid:proton symporter activity

amino acid:monoatomic cation antiporter activity [inference]

aspartate:glutamate, proton antiporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

aspartate:glutamate, proton antiporter activity

solute:proton symporter activity [inference]

amino acid:proton symporter activity [inference]

gamma-aminobutyric acid:proton symporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:proton symporter activity [inference]

gamma-aminobutyric acid:proton symporter activity

solute:proton symporter activity [inference]

amino acid:proton symporter activity [inference]

gamma-aminobutyric acid:proton symporter activity

antiporter activity [inference]

amino acid:monoatomic cation antiporter activity [inference]

aspartate:glutamate, proton antiporter activity

secondary active monocarboxylate transmembrane transporter activity [inference]

gamma-aminobutyric acid:proton symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:proton symporter activity [inference]

gamma-aminobutyric acid:proton symporter activity

solute:proton symporter activity [inference]

amino acid:proton symporter activity [inference]

gamma-aminobutyric acid:proton symporter activity

amino acid:monoatomic cation antiporter activity [inference]

aspartate:glutamate, proton antiporter activity

amide transmembrane transporter activity [inference]

salt transmembrane transporter activity [inference]

binding [inference]

protein binding [inference]

identical protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Mitochondrial carrier protein, calcium-binding

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
L-aspartate transmembrane transporter activity
L-glutamate transmembrane transporter activity
calcium ion binding
malate-aspartate shuttle

Displaying **all 6** entries
InterPro
EF-Hand 1, calcium-binding site
EF-hand domain pair
EF-hand domain
Mitochondrial carrier domain superfamily
Mitochondrial carrier protein
Mitochondrial substrate/solute carrier

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
membrane	FB:FBrf0231198
mitochondrion	PMID:19317464

Disease

Disease Ontology

Displaying **all 10** entries
DO ID	Disease Name	Source
DOID:0050432	Asperger syndrome	Alliance of Genome Resources
DOID:0050696	fetal alcohol spectrum disorder	Alliance of Genome Resources
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources
DOID:0070341	neonatal-onset type II citrullinemia	Alliance of Genome Resources
DOID:0070342	adult-onset type II citrullinemia	Alliance of Genome Resources
DOID:0080349	developmental and epileptic encephalopathy 39	Alliance of Genome Resources
DOID:12849	autistic disorder	Alliance of Genome Resources
DOID:1852	intrahepatic cholestasis	Alliance of Genome Resources
DOID:4137	common bile duct disease	Alliance of Genome Resources
DOID:9273	citrullinemia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 47 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Homo sapiens	8604		HGNC:10982
Homo sapiens	10165		HGNC:10983
Mus musculus	50799		MGI:1354721
Mus musculus	78830		MGI:1926080
Caenorhabditis elegans	175242		WB:WBGene00019326
Danio rerio	337675		ZFIN:ZDB-GENE-031006-11
Rattus norvegicus	362145		RGD:1305181
Xenopus tropicalis	549674		Xenbase:XB-GENE-1002100
Saccharomyces cerevisiae S288C	856132		SGD:S000006225
Drosophila pseudoobscura	4800386	7237_1:000b19

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements