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Guidelines

MIRAGE

myosin IA

Summary

Gene Symbol

MYO1A

Organism

Homo sapiens (human)

External Links

NCBI Gene

4640

PubChem

4640

Alliance of Genome Resources

HGNC:7595

Annotation

Keyword

ATP-binding
Actin-binding
Calmodulin-binding
Myosin
Phosphoprotein
Reference proteome
Repeat

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9UBC5	Brush border myosin I Myosin I heavy chain
B2R643	Brush border myosin I Myosin I heavy chain

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
endocytosis	IBA
actin filament organization	IBA
sensory perception of sound	IMP	12736868
sensory perception of sound	IBA
microvillus assembly	IEA

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis

actin filament-based process [inference]

actin filament-based movement

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

microvillus assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

microvillus assembly

plasma membrane bounded cell projection organization [inference]

microvillus organization [inference]

microvillus assembly

plasma membrane bounded cell projection assembly [inference]

microvillus assembly

supramolecular fiber organization [inference]

actin filament organization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

import into cell [inference]

endocytosis

organelle localization [inference]

vesicle localization

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
cytoplasm	IDA	9858156
cytoplasm	IBA
plasma membrane	IBA
microvillus	IDA	9858156
microvillus	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

plasma membrane region [inference]

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft

lateral plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

actin-based cell projection [inference]

microvillus

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

cortical cytoskeleton [inference]

cortical actin cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

cortical cytoskeleton [inference]

cortical actin cytoskeleton

cluster of actin-based cell projections [inference]

brush border

Displaying **all 4** entries
GO Term	Evidence Code	PMID
microfilament motor activity	IBA
calmodulin binding	IEA
ATP binding	IEA
actin filament binding	IBA

GO Hierarchy

molecular function

cytoskeletal motor activity [inference]

microfilament motor activity

binding [inference]

protein binding [inference]

calmodulin binding

cytoskeletal protein binding [inference]

actin binding [inference]

actin filament binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

actin filament binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

microfilament motor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

myosin

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
ATP binding
actin binding
actin filament binding
actin filament organization
cytoskeletal motor activity
nucleotide binding
vesicle transport along actin filament

Displaying **all 5** entries
InterPro
Class I myosin tail homology domain
IQ motif, EF-hand binding site
Kinesin motor domain superfamily
Myosin head, motor domain
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:10003	sensorineural hearing loss	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 59 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	4430	FB:FBgn0039157
Xenopus tropicalis	4640	Xenbase:XB-GENE-979281
Bos taurus	281936		BOVIN29585
Rattus norvegicus	299509		RATNO38069
Mus musculus	432516	Xenbase:XB-GENE-979281	MOUSE01131
Pan troglodytes	452002		PANTR05522
Canis lupus familiaris	607315		CANLF01331
Macaca mulatta	714033		MACMU05364
Equus caballus	100052722		HORSE36256
Taeniopygia guttata	100222131		TAEGU16253

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025