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ADP-ribosylserine hydrolase

Summary

Gene Symbol

ADPRS

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 521650
PubChem: 521650

Annotation

Keyword

Chromosome
Cytoplasm
DNA repair
Hydrolase
Magnesium
Metal-binding
Mitochondrion
Nucleus
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q3SYV9	ADP-ribose glycohydrolase ARH3 ADP-ribosylhydrolase 3 O-acetyl-ADP-ribose deacetylase ARH3 Poly(ADP-ribose) glycohydrolase ARH3 [Protein ADP-ribosylarginine] hydrolase-like protein 2 [Protein ADP-ribosylserine] hydrolase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
DNA repair
peptidyl-serine ADP-deribosylation
negative regulation of necroptotic process

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation [inference]

peptidyl-serine ADP-deribosylation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation [inference]

peptidyl-serine ADP-deribosylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation [inference]

peptidyl-serine ADP-deribosylation

macromolecule modification [inference]

protein modification process [inference]

protein de-ADP-ribosylation [inference]

peptidyl-serine ADP-deribosylation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation [inference]

peptidyl-serine ADP-deribosylation

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of programmed necrotic cell death [inference]

negative regulation of necroptotic process

regulation of cellular process [inference]

regulation of programmed cell death [inference]

negative regulation of programmed cell death [inference]

negative regulation of programmed necrotic cell death [inference]

negative regulation of necroptotic process

regulation of programmed necrotic cell death [inference]

regulation of necroptotic process [inference]

negative regulation of necroptotic process

negative regulation of programmed necrotic cell death [inference]

negative regulation of necroptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of programmed necrotic cell death [inference]

negative regulation of necroptotic process

Displaying **all 4** entries
GO Term	Evidence Code	PMID
site of DNA damage
mitochondrion	IEA	30032202
mitochondrial matrix
nucleus	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

site of DNA damage

Displaying **all 5** entries
GO Term	Evidence Code	PMID
hydrolase activity, hydrolyzing O-glycosyl compounds
ADP-ribosylserine hydrolase activity
magnesium ion binding
O-acetyl-ADP-ribose deacetylase activity
poly(ADP-ribose) glycohydrolase activity

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds

poly(ADP-ribose) glycohydrolase activity

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

ADP-ribosylserine hydrolase activity

deacetylase activity [inference]

O-acetyl-ADP-ribose deacetylase activity

catalytic activity, acting on a protein [inference]

ADP-ribosylserine hydrolase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Reverse transcriptase domain-containing protein

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Rhea

RHEA:52216

H₂O

ADP-D-ribose

Enzyme

3.2.1.143

PMID

Ortholog

Displaying entries **1 - 10** of 92 in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	54936	HUMAN48846
Mus musculus	100206	MOUSE42138
Rattus norvegicus	362600	RATNO34402
Pan troglodytes	456750	PANTR20638
Macaca mulatta	712758	MACMU21042
Danio rerio	796446	DANRE12490
Monodelphis domestica	100031418	MONDO25414
Equus caballus	100069360	HORSE28488
Ornithorhynchus anatinus	100079380	ORNAN08229
Taeniopygia guttata	100228514	TAEGU13557