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ADP-ribosylserine hydrolase

Summary

Gene Symbol

adprs

Organism

Danio rerio (zebrafish)

External Links

NCBI Gene

796446

PubChem

796446

Alliance of Genome Resources

ZFIN:ZDB-GENE-040912-85

Annotation

Keyword

Chromosome
Cytoplasm
DNA repair
Hydrolase
Magnesium
Metal-binding
Mitochondrion
Nucleus
Proteomics identification
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A8M3ARH3	ADP-ribose glycohydrolase ARH3 ADP-ribosylhydrolase 3 O-acetyl-ADP-ribose deacetylase ARH3 Poly(ADP-ribose) glycohydrolase ARH3 [Protein ADP-ribosylarginine] hydrolase-like protein 2 [Protein ADP-ribosylserine] hydrolase
Q66HT8	ADP-ribose glycohydrolase ARH3 ADP-ribosylhydrolase 3 O-acetyl-ADP-ribose deacetylase ARH3 Poly(ADP-ribose) glycohydrolase ARH3 [Protein ADP-ribosylarginine] hydrolase-like protein 2 [Protein ADP-ribosylserine] hydrolase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
DNA repair	ISS
DNA repair	IEA
DNA damage response	IEA
cellular response to DNA damage stimulus	IEA
negative regulation of necroptotic process	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation [inference]

peptidyl-serine ADP-deribosylation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation [inference]

peptidyl-serine ADP-deribosylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation [inference]

peptidyl-serine ADP-deribosylation

macromolecule modification [inference]

protein modification process [inference]

protein de-ADP-ribosylation [inference]

peptidyl-serine ADP-deribosylation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation [inference]

peptidyl-serine ADP-deribosylation

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of programmed necrotic cell death [inference]

negative regulation of necroptotic process

regulation of cellular process [inference]

regulation of programmed cell death [inference]

negative regulation of programmed cell death [inference]

negative regulation of programmed necrotic cell death [inference]

negative regulation of necroptotic process

regulation of programmed necrotic cell death [inference]

regulation of necroptotic process [inference]

negative regulation of necroptotic process

negative regulation of programmed necrotic cell death [inference]

negative regulation of necroptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of programmed necrotic cell death [inference]

negative regulation of necroptotic process

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
nucleus	ISS
nucleus	IBA
nucleus	IEA
chromosome	IEA
cytoplasm	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

site of DNA damage

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
magnesium ion binding	ISS
hydrolase activity, hydrolyzing O-glycosyl compounds	ISS
poly(ADP-ribose) glycohydrolase activity	ISS
poly(ADP-ribose) glycohydrolase activity	IEA
hydrolase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds

poly(ADP-ribose) glycohydrolase activity

hydrolase activity, hydrolyzing N-glycosyl compounds

ADP-ribosylserine hydrolase activity

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

deacetylase activity [inference]

O-acetyl-ADP-ribose deacetylase activity

catalytic activity, acting on a protein [inference]

ADP-ribosylserine hydrolase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

magnesium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ADP-ribose glycohydrolase ARH3

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism

Displaying 1 entry
Gene Ontology
hydrolase activity

Displaying **all 2** entries
InterPro
ADP-ribosylation/Crystallin J1 superfamily
ADP-ribosylation/Crystallin J1

Rhea

RHEA:52216

H₂O

ADP-D-ribose

Enzyme

3.2.1.143

PMID

Ortholog

Displaying entries **1 - 10** of 74 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	54936	Xenbase:XB-GENE-944445	HUMAN48846
Mus musculus	100206	Xenbase:XB-GENE-944445	MOUSE42138
Rattus norvegicus	362600		RATNO34402
Pan troglodytes	456750		PANTR20638
Bos taurus	521650		BOVIN27308
Xenopus tropicalis	548938	Xenbase:XB-GENE-944445
Macaca mulatta	712758		MACMU21042
Xenopus tropicalis	796446	Xenbase:XB-GENE-944445
Monodelphis domestica	100031418		MONDO25414
Equus caballus	100069360		HORSE28488

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

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Acknowledgements