phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

Summary
Gene Symbol
  • PIK3CA
Aliases
  • PI3K
Organism
Homo sapiens (human)
External Links
NCBI Gene
5290
HGNC
8975
KEGG Gene ID
hsa:5290
PubChem
5290
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • ATP-binding
  • Angiogenesis
  • Disease variant
  • Kinase
  • Lipid metabolism
  • Phagocytosis
  • Proto-oncogene
  • Reference proteome
  • Serine/threonine-protein kinase
Proteins
Displaying all 2 entries
UniProt Protein Name
P42336
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha
  • Phosphoinositide 3-kinase alpha
  • Phosphoinositide-3-kinase catalytic alpha polypeptide
  • Serine/threonine protein kinase PIK3CA
Q4LE51
Gene Ontology (GO)
GO Hierarchy
GO Hierarchy
Human Protein Atlas
ENSG00000121879

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

KEGG BRITE Database
Orthology
K00922
Name
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
References
Disease
Disease Ontology
Displaying entries 1 - 10 of 1117 in total
DO ID Disease Name Source
DOID:0001816 angiosarcoma
DOID:0002116 pterygium
DOID:0014667 disease of metabolism
DOID:0040085 bacterial sepsis
DOID:0050012 chikungunya
DOID:0050156 idiopathic pulmonary fibrosis
DOID:0050328 congenital hypothyroidism
DOID:0050387 nonpapillary renal cell carcinoma
DOID:0050424 familial adenomatous polyposis
DOID:0050428 nonepidermolytic palmoplantar keratoderma
The Human Phenotype Ontology
Displaying entries 1 - 10 of 306 in total
HPO ID HPO Term
HP:0000006 Autosomal dominant inheritance
HP:0000020 Urinary incontinence
HP:0000034 Hydrocele testis
HP:0000036 Abnormal penis morphology
HP:0000044 Hypogonadotropic hypogonadism
HP:0000077 Abnormality of the kidney
HP:0000089 Renal hypoplasia
HP:0000098 Tall stature
HP:0000105 Enlarged kidney
HP:0000130 Abnormality of the uterus
Displaying entries 21 - 22 of 22 in total
Disease ID Disease Name
ORPHA:99802
  • hemimegalencephaly
OMIM:162900
  • nevus, epidermal
PubChem Disease
GHR Health Conditions
MedGen Diseases
OMIM Phenotypes
KEGG Diseases
LIPID MAPS Gene / Proteome Database
LMPD ID
LMP001325
Gene Name
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

About Release Notes Help Feedback

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


Logo License Policies Site Map

Contact: support@glycosmos.org

This work is licensed under Creative Commons Attribution 4.0 International


GlyCosmos Portal v4.0.0

Last updated: August 19, 2024