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prion protein (Kanno blood group)
Summary
- Gene Symbol
-
- PRNP
- Aliases
-
- AltPrP
- CD230
- Creutzfeldt-Jakob disease
- Gerstmann-Strausler-Scheinker syndrome
- PRP
- fatal familial insomnia
- p27-30
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative initiation
- Amyloidosis
- Cell membrane
- Copper
- Direct protein sequencing
- Disease variant
- Disulfide bond
- GPI-anchor
- Golgi apparatus
- Growth arrest
- Metal-binding
- Mitochondrion outer membrane
- Prion
- Reference proteome
- Repeat
- Signal
- Transmembrane helix
- Zinc
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| negative regulation of protein phosphorylation | ||
| negative regulation of calcineurin-NFAT signaling cascade | ||
| positive regulation of protein targeting to membrane | ||
| negative regulation of T cell receptor signaling pathway | ||
| negative regulation of protein processing |
GO Hierarchy
- negative regulation of long-term synaptic potentiation
- regulation of cell cycle
biological process
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
negative regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
negative regulation of macromolecule metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
negative regulation of metabolic process [inference]
negative regulation of cellular process [inference]
negative regulation of multicellular organismal process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
negative regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of cell population proliferation [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of cellular localization [inference]
regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| ATP-dependent protein binding | ||
| protein-containing complex binding | ||
| protein-folding chaperone binding | ||
| cuprous ion binding |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Prion protein
- Functional Category
-
- E: Amino acid transport and metabolism
- G: Carbohydrate transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
| Gene Ontology |
|---|
| metal ion binding |
| protein homooligomerization |
| InterPro |
|---|
| Prion protein |
| Prion/Doppel beta-ribbon domain superfamily |
| Prion/Doppel protein, beta-ribbon domain |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050433 | fatal familial insomnia | |
| DOID:0090103 | Huntington's disease-like 1 | |
| DOID:11949 | Creutzfeldt-Jakob disease | |
| DOID:4195 | hyperglycemia | |
| DOID:4249 | Gerstmann-Straussler-Scheinker syndrome | |
| DOID:5434 | scrapie | |
| DOID:648 | kuru |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000639 | Nystagmus |
| HP:0000651 | Diplopia |
| HP:0000708 | Atypical behavior |
| HP:0000709 | Psychosis |
| HP:0000710 | Hyperorality |
| HP:0000711 | Restlessness |
| HP:0000712 | Emotional lability |
| HP:0000716 | Depression |
| HP:0000718 | Aggressive behavior |
| HP:0000726 | Dementia |
| Disease ID | Disease Name |
|---|---|
| OMIM:606688 |
|
| OMIM:123400 |
|
| OMIM:603218 |
|
| OMIM:137440 |
|
| ORPHA:157941 |
|
| ORPHA:280397 |
|
| OMIM:600072 |
|
| ORPHA:356 |
|
| ORPHA:282166 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 717859 | MACMU01894 | |||
| 100008658 | RABIT10184 | |||
| 100065904 | HORSE21259 | |||
| 100086593 | ORNAN22428 | |||
| 100158502 | Xenbase:XB-GENE-952814 | |||
| 100173712 | 9601_0:004dd1 | PONAB20342 | ||
| 100555750 | ANOCA14222 | |||
| 100587690 | NOMLE06238 | |||
| 100671000 | LOXAF12952 | |||
| 100714701 | CAVPO04736 |
