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sorting nexin 1

Summary

Gene Symbol

Snx1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

56440

PubChem

56440

Alliance of Genome Resources

MGI:1928395

Annotation

Keyword

3D-structure
Acetylation
Cell projection
Endosome
Golgi apparatus
Lipid-binding
Membrane
Phosphoprotein
Protein transport
Proteomics identification
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9WV80
Q6NZD2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
intracellular protein transport	ISO
intracellular protein transport	IEA
negative regulation of transforming growth factor beta receptor signaling pathway	IDA	15239668
neuron projection development	IDA	24261326
receptor internalization	ISS

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

endosomal transport [inference]

retrograde transport, endosome to Golgi

early endosome to Golgi transport

Golgi vesicle transport [inference]

early endosome to Golgi transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

endosomal transport [inference]

retrograde transport, endosome to Golgi

early endosome to Golgi transport

cytosolic transport [inference]

retrograde transport, endosome to Golgi

early endosome to Golgi transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

lamellipodium morphogenesis

plasma membrane bounded cell projection organization [inference]

neuron projection development

lamellipodium organization [inference]

lamellipodium morphogenesis

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

lamellipodium morphogenesis

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

endosomal transport [inference]

retrograde transport, endosome to Golgi

early endosome to Golgi transport

Golgi vesicle transport [inference]

early endosome to Golgi transport

intracellular transport [inference]

intracellular protein transport

endosomal transport [inference]

retrograde transport, endosome to Golgi

early endosome to Golgi transport

cytosolic transport [inference]

retrograde transport, endosome to Golgi

early endosome to Golgi transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

endosomal transport [inference]

retrograde transport, endosome to Golgi

early endosome to Golgi transport

cytosolic transport [inference]

retrograde transport, endosome to Golgi

early endosome to Golgi transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

endosomal transport [inference]

retrograde transport, endosome to Golgi

early endosome to Golgi transport

cytosolic transport [inference]

retrograde transport, endosome to Golgi

early endosome to Golgi transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of cellular response to transforming growth factor beta stimulus [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

Displaying entries **1 - 5** of 29 in total

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GO Term	Evidence Code	PMID
cytoplasm	ISO
lysosome	ISO
endosome	ISO
endosome	IDA	15078902
endosome	IBA

GO Hierarchy

cellular component

protein-containing complex

membrane protein complex [inference]

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

early endosome membrane

bounding membrane of organelle [inference]

endosome membrane

early endosome membrane

extrinsic component of membrane [inference]

extrinsic component of organelle membrane [inference]

extrinsic component of endosome membrane [inference]

extrinsic component of postsynaptic endosome membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

neuron projection [inference]

neuron spine [inference]

dendritic spine

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

early endosome

intracellular membrane-bounded organelle

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

early endosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

postsynaptic specialization, intracellular component [inference]

postsynaptic density, intracellular component

intracellular organelle [inference]

intracellular membrane-bounded organelle

vacuole [inference]

lytic vacuole [inference]

lysosome

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

early endosome

intracellular non-membrane-bounded organelle [inference]

postsynaptic specialization, intracellular component [inference]

postsynaptic density, intracellular component

postsynaptic specialization [inference]

postsynaptic density

postsynapse [inference]

dendritic spine

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
epidermal growth factor receptor binding	ISO
insulin receptor binding	ISO
protein binding	IPI	15239668 24261326
phosphatidylinositol binding	ISS
phosphatidylinositol binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

insulin receptor binding

growth factor receptor binding [inference]

epidermal growth factor receptor binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Sorting nexin

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
phosphatidylinositol binding

Displaying **all 3** entries
InterPro
AH/BAR domain superfamily
PX domain superfamily
Phox homology

Ortholog

Displaying entries **1 - 10** of 64 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	6642		HUMAN23561
Saccharomyces cerevisiae S288C	6643	SGD:S000005595
Xenopus tropicalis	56440	Xenbase:XB-GENE-992259
Saccharomyces cerevisiae S288C	67804	SGD:S000005595
Rattus norvegicus	84471		RATNO40452
Danio rerio	337386		DANRE27426
Pan troglodytes	453503		PANTR10534
Canis lupus familiaris	478336		CANLF12591
Bos taurus	512029		BOVIN01192
Macaca mulatta	706544		MACMU42991

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements